Search Results - "Taite, Beatrice B."

Pharmacological intervention at disparate sites in the coagulation cascade: Comparison of anti-thrombotic efficacy vs. bleeding propensity in a rat model of acute arterial thrombosis by SZALONY, James A, TAITE, Beatrice B, GIRARD, Thomas J, NICHOLSON, Nancy S, LACHANCE, Rhonda M

“…The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation,…”
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Orbofiban: An orally active GPIIb/IIIa platelet receptor antagonist by Nicholson, Nancy S., Abood, Norman A., Panzer-Knodle, Susan G., Frederick, Leo G., Page, Jimmy D., Salyers, Anita K., Suleymanov, Osman D., Szalony, James A., Taite, Beatrice B., Anders, Robert J.

“…A key role has been established for platelet activation and thrombus formation in the pathogenesis of acute coronary syndromes, and restenosis after…”
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SC-54684A : an orally active inhibitor of platelet aggregation by NICHOLSON, N. S, PANZER-KNODLE, S. G, ENGLEMAN, V. W, HERIN, M, JACQMIN, P, FEIGEN, L. P, SALYERS, A. K, TAITE, B. B, SZALONY, J. A, HAAS, N. F, KING, L. W, ZABLOCKI, J. A, KELLER, B. T, BROSCHAT, K

“…Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be…”
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Extended inhibition of platelet aggregation with the orally active platelet inhibitor SC-54684A by SZALONY, J. A, HAAS, N. F, SALYERS, A. K, TAITE, B. B, NICHOLSON, N. S, MEHROTRA, D. V, FEIGEN, L. P

“…Platelet aggregation is important in thrombotic events, and platelets play a major role in the etiology of several cardiovascular diseases. Platelet…”
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Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin by FREDERICK, L. G, SULEYMANOV, O. D, SZALONY, J. A, TAITE, B. B, SALYERS, A. K, KING, L. W, FEIGEN, L. P, NICHOLSON, N. S

“…Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in antithrombotic…”
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Species variation in the effect of glycoprotein IIb/IIIa antagonists on inhibition of platelet aggregation by Panzer-Knodle, S, Taite, B B, Mehrotra, D V, Nicholson, N S, Feigen, L P

“…Differences exist between platelets of different species in their reaction to pharmaceutical agents, such as inhibitors of platelet aggregation. Understanding…”
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Assessment of platelet function assays by Nicholson, Nancy S., Panzer-Knodle, Susan G., Haas, Neal F., Taite, Beatrice B., Szalony, James A., Page, Jimmy D., Feigen, Larry P., Lansky, David M., Salyers, Anita K.

“…Optical aggregometry, traditionally used to assess platelet function, is highly dependent on sample preparation and technical procedure; as a result, data from…”
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Potent in Vitro and in Vivo Inhibitors of Platelet Aggregation Based Upon the Arg-Gly-Asp Sequence of Fibrinogen. (Aminobenzamidino)succinyl (ABAS) Series of Orally Active Fibrinogen Receptor Antagonists by Zablocki, Jeffery A, Rico, Joseph G, Garland, Robert B, Rogers, Thomas E, Williams, Kenneth, Schretzman, Lori A, Rao, Shashidhar A, Bovy, Philippe R, Tjoeng, Foe S

“…Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our i.v. antiplatelet…”
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Protective effect of oral xemilofiban in arterial thrombosis in dogs: Incresed activity in combination with aspirin by Frederick, Leo G, Suleymanov, Osman D, Szalony, James A, Taite, Beatrice B

“…BACKGROUND: Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in…”
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Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor by Zablocki, Jeffery A, Miyano, Masateru, Garland, Robert B, Pireh, Daisy, Schretzman, Lori, Rao, Shashidhar N, Lindmark, Richard J, Panzer-Knodle, Susan G, Nicholson, Nancy S

“…Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in…”
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A novel series of orally active antiplatelet agents by Zablocki, Jeffery A., Tjoeng, Foe S., Bovy, Philippe R., Miyano, Masateru, Garland, Robert B., Williams, Kenneth, Schretzman, Lori, Zupec, Mark E., Rico, Joseph G., Lindmark, Richard J., Toth, Mihaly V., McMackins, Dudley E., Adams, Steven P., Panzer-Knodle, Susan G., Nicholson, Nancy S., Taite, Beatrice B., Salyers, Anita K., King, Lucy W., Campion, James G., Feigen, Larry P.

“…A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet…”
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SC-49992--a potent and specific inhibitor of platelet aggregation by Nicholson, N S, Panzer-Knodle, S G, King, L W, Taite, B B, Keller, B T, Tjoeng, F S, Engleman, V W, Giorgio, T D, Feigen, L P

“…Fibrinogen binding is required for platelet aggregation and subsequent thrombus formation. SC-49992 (SC), an RGDF mimetic, is a potent and specific inhibitor…”
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