Search Results - "Tait, Stephen WG"

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness by Fanfone, Deborah, Wu, Zhichong, Mammi, Jade, Berthenet, Kevin, Neves, David, Weber, Kathrin, Halaburkova, Andrea, Virard, François, Bunel, Félix, Jamard, Catherine, Hernandez-Vargas, Hector, Tait, Stephen W G, Hennino, Ana, Ichim, Gabriel

“…Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Mitochondrial DNA in inflammation and immunity by Riley, Joel S, Tait, Stephen WG

“…Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and…”
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A fate worse than death: apoptosis as an oncogenic process by Ichim, Gabriel, Tait, Stephen W. G.

“…Apoptotic cell death undoubtedly has beneficial roles in cancer, but paradoxically, apoptosis can also cause unwanted effects that could promote cancer. This…”
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Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis by Riley, Joel S, Quarato, Giovanni, Cloix, Catherine, Lopez, Jonathan, O'Prey, Jim, Pearson, Matthew, Chapman, James, Sesaki, Hiromi, Carlin, Leo M, Passos, João F, Wheeler, Ann P, Oberst, Andrew, Ryan, Kevin M, Tait, Stephen WG

“…During apoptosis, pro‐apoptotic BAX and BAK are activated, causing mitochondrial outer membrane permeabilisation (MOMP), caspase activation and cell death…”
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Mitochondria and cell signalling by Tait, Stephen W G, Green, Douglas R

“…Mitochondria have long been considered as crucial organelles, primarily for their roles in biosynthetic reactions such as ATP synthesis. However, it is…”
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Mitochondria and the hallmarks of cancer by Giampazolias, Evangelos, Tait, Stephen W.G.

“…Mitochondria have traditionally been viewed as the powerhouse of the cell, where they serve, amongst other functions, as a major source of ATP generation. More…”
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 by Galluzzi, Lorenzo, Vitale, Ilio, Abrams, John M., Agostinis, Patrizia, Amelio, Ivano, Andrews, David W., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bertrand, Mathieu J. M., Blagosklonny, Mikhail V., Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Carmona-Gutierrez, Didac, Chan, Francis K.-M., Cheng, Emily H., Ciechanover, Aaron, Conrad, Marcus, Cubillos-Ruiz, Juan R., De Laurenzi, Vincenzo, De Maria, Ruggero, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J., Garrido, Carmen, Gavathiotis, Evripidis, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hardwick, J. Marie, Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Knight, Richard A., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., López-Otín, Carlos, Lowe, Scott W., Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Medema, Jan Paul, Meier, Pascal, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Nagata, Shigekazu, Nuñez, Gabriel, Oren, Moshe, Pasparakis, Manolis, Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Rehm, Markus, Ryan, Kevin M., Shao, Feng, Shi, Yufang, Silke, John, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tang, Daolin, Tsujimoto, Yoshihide, Turk, Boris, Vandenabeele, Peter, Vander Heiden, Matthew G., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido

“…Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from…”
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MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D by Gutierrez, Kimberley D, Davis, Michael A, Daniels, Brian P, Olsen, Tayla M, Ralli-Jain, Pooja, Tait, Stephen W G, Gale, Jr, Michael, Oberst, Andrew

“…Necroptosis is a form of programmed cell death defined by activation of the kinase receptor interacting protein kinase 3 and its downstream effector, the…”
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Mitochondria are required for pro-ageing features of the senescent phenotype by Correia-Melo, Clara, Marques, Francisco DM, Anderson, Rhys, Hewitt, Graeme, Hewitt, Rachael, Cole, John, Carroll, Bernadette M, Miwa, Satomi, Birch, Jodie, Merz, Alina, Rushton, Michael D, Charles, Michelle, Jurk, Diana, Tait, Stephen WG, Czapiewski, Rafal, Greaves, Laura, Nelson, Glyn, Bohlooly-Y, Mohammad, Rodriguez-Cuenca, Sergio, Vidal-Puig, Antonio, Mann, Derek, Saretzki, Gabriele, Quarato, Giovanni, Green, Douglas R, Adams, Peter D, von Zglinicki, Thomas, Korolchuk, Viktor I, Passos, João F

“…Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype,…”
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PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness by Rabas, Nicolas, Palmer, Sarah, Mitchell, Louise, Ismail, Shehab, Gohlke, Andrea, Riley, Joel S, Tait, Stephen W G, Gammage, Payam, Soares, Leandro Lemgruber, Macpherson, Iain R, Norman, Jim C

“…The cystine-glutamate antiporter, xCT, supports a glutathione synthesis program enabling cancer cells to cope with metabolically stressful microenvironments…”
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Mitochondria and pathogen immunity: from killer to firestarter by Riley, Joel S, Tait, Stephen WG

“…Serving as an innate defence mechanism, invading pathogens elicit a broad inflammatory response in cells. In this issue, Brokatzky et al (2019) report that…”
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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis by Cleveland, John L, Sanjuan, Miguel A, Dillon, Christopher P, Green, Douglas R, Moshiach, Simon, Tanaka, Keiji, Dorsey, Frank, Withoff, Sebo, Komatsu, Masaaki, Connell, Samuel, Tait, Stephen W. G

“…Phagocytosis and autophagy are two ancient, highly conserved processes involved, respectively, in the removal of extracellular organisms and the destruction of…”
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Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response by Vringer, Esmee, Heilig, Rosalie, Riley, Joel S, Black, Annabel, Cloix, Catherine, Skalka, George, Montes-Gómez, Alfredo E, Aguado, Aurore, Lilla, Sergio, Walczak, Henning, Gyrd-Hansen, Mads, Murphy, Daniel J, Huang, Danny T, Zanivan, Sara, Tait, Stephen WG

“…Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and…”
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Monocytes mediate Salmonella Typhimurium‐induced tumor growth inhibition in a mouse melanoma model by Johnson, Síle A., Ormsby, Michael J., Wessel, Hannah M., Hulme, Heather E., Bravo‐Blas, Alberto, McIntosh, Anne, Mason, Susan, Coffelt, Seth B., Tait, Stephen W.G., Mowat, Allan McI, Milling, Simon W.F., Blyth, Karen, Wall, Daniel M.

“…The use of bacteria as an alternative cancer therapy has been reinvestigated in recent years. SL7207: an auxotrophic Salmonella enterica serovar Typhimurium…”
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Mitochondrial pathway of apoptosis is ancestral in metazoans by Bender, Cheryl E., Fitzgerald, Patrick, Tait, Stephen W. G., Llambi, Fabien, McStay, Gavin P., Tupper, Douglas O., Pellettieri, Jason, Alvarado, Alejandro Sánchez, Salvesen, Guy S., Green, Douglas R.

“…The mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in vertebrates. In this pathway, proapoptotic members of the Bcl-2…”
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Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis by Riley, Joel S, Quarato, Giovanni, Cloix, Catherine, Lopez, Jonathan, O'Prey, Jim, Pearson, Matthew, Chapman, James, Sesaki, Hiromi, Carlin, Leo M, Passos, João F, Wheeler, Ann P, Oberst, Andrew, Ryan, Kevin M, Tait, Stephen WG

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Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment by Tait, Stephen W.G, de Vries, Evert, Maas, Chiel, Keller, Anna M, D'Santos, Clive S, Borst, Jannie

“…Bcl-2 family member Bid is subject to autoinhibition; in the absence of stimuli, its N-terminal region sequesters the proapoptotic Bcl-2 homology 3 (BH3)…”
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Necroptosis: Fifty shades of RIPKs by Ichim, Gabriel, Tait, Stephen WG

“…Apoptosis and necroptosis are 2 major, yet distinct, forms of regulated cell death. Whereas apoptosis requires caspase protease function, necroptosis requires…”
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