Search Results - "Tainaka, Hitoshi"

Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse by Shimizu, Midori, Tainaka, Hitoshi, Oba, Taro, Mizuo, Keisuke, Umezawa, Masakazu, Takeda, Ken

“…Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that…”
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HsfA1d and HsfA1e involved in the transcriptional regulation of HsfA2 function as key regulators for the Hsf signaling network in response to environmental stress by Nishizawa-Yokoi, Ayako, Nosaka, Ryota, Hayashi, Hideki, Tainaka, Hitoshi, Maruta, Takanori, Tamoi, Masahiro, Ikeda, Miho, Ohme-Takagi, Masaru, Yoshimura, Kazuya, Yabuta, Yukinori, Shigeoka, Shigeru

“…Heat shock transcription factor A2 (HsfA2) acts as a key component of the Hsf signaling network involved in cellular responses to various types of…”
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Effect of fetal exposure to titanium dioxide nanoparticle on brain development − brain region information by Umezawa, Masakazu, Tainaka, Hitoshi, Kawashima, Natsuko, Shimizu, Midori, Takeda, Ken

“…The production of man-made nanoparticles is increasing in nanotechnology, and health effect of nanomaterials is of concern. We previously reported that fetal…”
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The 26S Proteasome Function and Hsp90 Activity Involved in the Regulation of HsfA2 Expression in Response to Oxidative Stress by Nishizawa-Yokoi, Ayako, Tainaka, Hitoshi, Yoshida, Eriko, Tamoi, Masahiro, Yabuta, Yukinori, Shigeoka, Shigeru

“…Heat shock transcription factor A2 (HsfA2) is induced under environmental stress and regulates transcription of various defense-related genes. Thus HsfA2 plays…”
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Heap: a highly sensitive and accurate SNP detection tool for low-coverage high-throughput sequencing data by Kobayashi, Masaaki, Ohyanagi, Hajime, Takanashi, Hideki, Asano, Satomi, Kudo, Toru, Kajiya-Kanegae, Hiromi, Nagano, Atsushi J, Tainaka, Hitoshi, Tokunaga, Tsuyoshi, Sazuka, Takashi, Iwata, Hiroyoshi, Tsutsumi, Nobuhiro, Yano, Kentaro

“…Recent availability of large-scale genomic resources enables us to conduct so called genome-wide association studies (GWAS) and genomic prediction (GP)…”
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Evaluation of the testicular toxicity of prenatal exposure to bisphenol A based on microarray analysis combined with MeSH annotation by Tainaka, Hitoshi, Takahashi, Hikari, Umezawa, Masakazu, Tanaka, Hiromitsu, Nishimune, Yoshitake, Oshio, Shigeru, Takeda, Ken

“…Bisphenol A (BPA) is known to be an endocrine disruptor that affects the development of reproductive system. The aim of the present study was to investigate a…”
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Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression by Takahashi, Hikari, Tainaka, Hitoshi, Umezawa, Masakazu, Takeda, Ken, Tanaka, Hiromitsu, Nishimune, Yoshitake, Oshio, Shigeru

“…Testicular toxicity of chemical substances has been generally assessed by sperm properties and histology. However, the methods can provide only a few…”
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Meichroacidin Containing the Membrane Occupation and Recognition Nexus Motif Is Essential for Spermatozoa Morphogenesis by Tokuhiro, Keizo, Hirose, Mika, Miyagawa, Yasushi, Tsujimura, Akira, Irie, Shinji, Isotani, Ayako, Okabe, Masaru, Toyama, Yoshiro, Ito, Chizuru, Toshimori, Kiyotaka, Takeda, Ken, Oshio, Shigeru, Tainaka, Hitoshi, Tsuchida, Junji, Okuyama, Akihiko, Nishimune, Yoshitake, Tanaka, Hiromitsu

“…Meichroacidin (MCA) is a highly hydrophilic protein that contains the membrane occupation and recognition nexus motif. MCA is expressed during the stages of…”
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Effect of prenatal exposure to titanium dioxide nanoparticles on gene expression in mouse brain by Shimizu, Midori, Mizuo, Keisuke, Tainaka, Hitoshi, Umezawa, Masakazu, Takeda, Ken

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Long-term alteration of gene expression without morphological change in testis after neonatal exposure to genistein in mice: toxicogenomic analysis using cDNA microarray by Adachi, Tetsuya, Ono, Yushin, Koh, Kyu-Bom, Takashima, Kyoka, Tainaka, Hitoshi, Matsuno, Yoshiharu, Nakagawa, Soichi, Todaka, Emiko, Sakurai, Kenichi, Fukata, Hideki, Iguchi, Taisen, Komiyama, Masatoshi, Mori, Chisato

“…In this study, we carried out toxicogenomic analysis using in-house cDNA microarray to ascertain the long-term effects of neonatal exposure to genistein, also…”
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Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis by Ieiri, I, Tainaka, H, Morita, T, Hadama, A, Mamiya, K, Hayashibara, M, Ninomiya, H, Ohmori, S, Kitada, M, Tashiro, N, Higuchi, S, Otsubo, K

“…This study evaluated the catalytic activity of three variants (Ile, Leu, and Thr) at codon 359 of CYP2C9 enzymes expressed in a yeast cDNA expression system,…”
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Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol by Yamazaki, Koji, Fukata, Hideki, Adachi, Tetsuya, Tainaka, Hitoshi, Kohda, Masao, Yamazaki, Masashi, Kojima, Kensuke, Chiba, Kan, Mori, Chisato, Komiyama, Masatoshi

“…The aim of this study was to investigate the molecular changes that underlie morphological changes in the epididymis following neonatal exposure to potent…”
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Molecular biological features of male germ cell differentiation by TANAKA, HIROMITSU, HIROSE, MIKA, TOKUHIRO, KEIZO, TAINAKA, HITOSHI, MIYAGAWA, YASUSHI, TSUJIMURA, AKIRA, OKUYAMA, AKIHIKO, NISHIMUNE, YOSHITAKE

“…Somatic cell differentiation is required throughout the life of a multicellular organism to maintain homeostasis. In contrast, germ cells have only one…”
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Pharmacokinetic Interaction between Warfarin and a Uricosuric Agent, Bucolome: Application of In Vitro Approaches to Predicting In Vivo Reduction of (S)-Warfarin Clearance by TAKAHASHI, H, KASHIMA, T, KIMURA, S, MURATA, N, TAKABA, T, IWADE, K, ABE, T, TAINAKA, H, YASUMORI, T, ECHIZEN, H

“…A uricosuric agent, bucolome, has been shown to intensify the anticoagulant effect of warfarin. The aims of the present study were to clarify its mechanism(s)…”
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ナノマテリアルの次世代健康影響—妊娠期曝露の子に及ぼす影響 by 武田, 健, 新海, 雄介, 鈴木, 健一郎, 柳田, 信也, 梅澤, 雅和, 横田, 理, 田井中, 均, 押尾, 茂, 井原, 智美, 菅又, 昌雄

“…「1. はじめに」都市圏では, 浮遊粒子状物質の半分近くがディーゼル車由来といわれている. われわれは, そのディーゼル車が排出するガスを妊娠中の母マウスに吸わせ, 生まれてきた仔の生殖系, 脳神経系などへの影響を検討してきた. その結果, 排ガス由来と思われるナノサイズ(100nm以下)の黒い粒子状物質が,…”
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Microarray analysis provides insight into the early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium by Umezawa, Masakazu, Tanaka, Naomi, Tainaka, Hitoshi, Takeda, Ken, Ihara, Tomomi, Sugamata, Masao

“…To characterize the biochemical alterations that occur in the peritoneal tissue of the mouse endometriosis model during early development of the lesion using…”
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Modulation of Ethanol-Mediated CYP2E1 Induction by Clofibrate and L-Carnitine in Rat Liver by TAINAKA, Hitoshi, NAITO, Tsuneko, MURAYAMA, Norie, YAMAZOE, Yasushi, KATO, Ryuichi

“…To understand the effects of lipid-lowering agents on the ethanol-induction of hepatic CYP2E1, clofibrate and L-carnitine were administrated to adult male…”
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Health Effects of Nanomaterials on Next Generation by TAKEDA, Ken, SHINKAI, Yusuke, SUZUKI, Ken-ichiro, YANAGITA, Shinya, UMEZAWA, Masakazu, YOKOTA, Satoshi, TAINAKA, Hitoshi, OSHIO, Shigeru, IHARA, Tomomi, SUGAMATA, Masao

“…In order to discuss the health effects of nanomaterials, we cannot disregard the research on the health effects of airborne particulates. It is said that many…”
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Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone by Takahashi, Harumi, Sato, Teruki, Shimoyama, Yoshiaki, Shioda, Noriko, Shimizu, Teppei, Kubo, Suzuko, Tamura, Noboru, Tainaka, Hitoshi, Yasumori, Toshio, Echizen, Hirotoshi

“…Objective To clarify the mechanism(s) for the interaction between warfarin and benzbromarone, a uricosuric agent, and to predict changes in the in vivo…”
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Effects of G169R and P34S Substitutions Produced by Mutations ofCYP2D614 on the Functional Properties of CYP2D6 Expressed in V79 Cells by Tomoko Shiraishi, Masakiyo Hosokawa, Kaoru Kobayashi, Hitoshi Tainaka, Yoshiyuki Yamaura, Miwo Taguchi, Kan Chiba

“…CYP2D6 is a polymorphic enzyme that catalyzes the oxidation of various drugs. At least 40-mutant alleles of CYP2D6 have been reported. CYP2D6*14 , which is one…”
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