Search Results - "Taillon, Bruce E"
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Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome
Published in Science (American Association for the Advancement of Science) (19-10-2007)“…Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of…”
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Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation
Published in Viruses (06-06-2023)“…Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is a highly contagious disease of cloven-hoofed livestock that can have severe economic impacts…”
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The evolutionary analysis of emerging low frequency HIV-1 CXCR4 using variants through time--an ultra-deep approach
Published in PLoS computational biology (16-12-2010)“…Large-scale parallel pyrosequencing produces unprecedented quantities of sequence data. However, when generated from viral populations current mapping software…”
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4
Transcriptome sequencing of malignant pleural mesothelioma tumors
Published in Proceedings of the National Academy of Sciences - PNAS (04-03-2008)“…Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA mutations and expression levels…”
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5
Second generation sequencing of the mesothelioma tumor genome
Published in PloS one (13-05-2010)“…The current paradigm for elucidating the molecular etiology of cancers relies on the interrogation of small numbers of genes, which limits the scope of…”
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Analysis of TSC Cortical Tubers by Deep Sequencing of TSC1, TSC2 and KRAS Demonstrates that Small Second-Hit Mutations in these Genes are Rare Events
Published in Brain pathology (Zurich, Switzerland) (01-11-2010)“…Tuberous sclerosis complex (TSC) is an often severe neurocutaneous syndrome. Cortical tubers are the predominant neuropathological finding in TSC, and their…”
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Ultra deep sequencing detects a low rate of mosaic mutations in tuberous sclerosis complex
Published in Human genetics (01-05-2010)“…Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome caused by mutations in TSC1 and TSC2. However, 10-15% TSC patients have no…”
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Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing
Published in AIDS (London) (19-06-2009)“…Identification of low-frequency variants is of clinical importance in the identification of preexisting drug resistance. Using 'ultra-deep' sequencing, we…”
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"One plate/three-reporter" assay format for the detection and validation of yeast two-hybrid interactions
Published in BioTechniques (01-11-2004)“…We describe a novel assay format for the Gal4-based yeast two-hybrid-system, in which the readout from three different reporter genes is measured sequentially…”
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10
BIA/MS of Epitope-Tagged Peptides Directly from E. Coli Lysate: Multiplex Detection and Protein Identification at Low-Femtomole to Subfemtomole Levels
Published in Analytical chemistry (Washington) (15-07-1999)“…The use of biomolecular interaction analysis mass spectrometry to selectively isolate, detect, and characterize epitope-tagged peptides present in total cell…”
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Simultaneous gene expression analysis of steady‐state and actively translated mRNA populations from osteosarcoma MG‐63 cells in response to IL‐1α via an open expression analysis platform
Published in Nucleic acids research (01-09-2003)“…Pro‐inflammatory cytokines play a key role in various forms of metabolic bone diseases, including osteopenia and osteoporosis. Human MG‐63 cells treated with…”
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Mutational analysis of centrin: an EF-hand protein associated with three distinct contractile fibers in the basal body apparatus of Chlamydomonas
Published in The Journal of cell biology (01-12-1992)“…Centrin, a 20-kD phosphoprotein with four calcium-binding EF-hands, is present in the centrosome/basal body apparatus of the green alga Chlamydomonas…”
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WECHE: A Novel Hematopoietic Regulatory Factor
Published in Immunity (Cambridge, Mass.) (01-02-2000)“…Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a…”
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The Melanoma Vascular Mimicry Phenotype Defined in Gene Expression and Microsome Sequencing Analysis
Published in Cancer genomics & proteomics (01-09-2004)“…The phenomenon of vasculogenic mimicry in melanoma has been recently described to be an important factor relating to melanoma progression. Large scale gene…”
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15
The evolutionary analysis of emerging low frequency HIV-1 CXCR4 using variants through time--an ultradeep approach
Published in PLoS computational biology (01-12-2010)“…Large-scale parallel pyrosequencing produces unprecedented quantities of sequence data. However, when generated from viral populations current mapping software…”
Get full text
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16
The Evolutionary Analysis of Emerging Low Frequency HIV-1 CXCR4 Using Variants through Time--An Ultra-Deep Approach: e1001022
Published in PLoS computational biology (01-12-2010)“…Large-scale parallel pyrosequencing produces unprecedented quantities of sequence data. However, when generated from viral populations current mapping software…”
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Open systems: panoramic views of gene expression
Published in Journal of immunological methods (01-04-2001)“…Since their development in the early 1990s, differential gene expression (DGE) technologies have been applied to a multitude of biological challenges, both for…”
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regA, a Volvox gene that plays a central role in germ-soma differentiation, encodes a novel regulatory protein
Published in Development (Cambridge) (01-02-1999)“…Volvox has two cell types: mortal somatic cells and immortal germ cells. Here we describe the transposon-tagging, cloning and characterization of regA, which…”
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STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H+-ATPase subunit Vph1p
Published in The Journal of biological chemistry (13-05-1994)“…The Saccharomyces cerevisiae gene, VPH1 (Vacuolar pH 1), encodes a 95-kDa integral membrane subunit of the vacuolar-type H+-ATPase (V-ATPase) that is required…”
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Simultaneous gene expression analysis of steady-state and actively translated mRNA populations from osteosarcoma MG-63 cells in response to IL-1 via an open expression analysis platform
Published in Nucleic acids research (01-09-2003)“…Pro-inflammatory cytokines play a key role in various forms of metabolic bone diseases, including osteopenia and osteoporosis. Human MG-63 cells treated with…”
Get full text
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