Search Results - "Tailford, Louise E"

Mucin glycan foraging in the human gut microbiome by Tailford, Louise E, Crost, Emmanuelle H, Kavanaugh, Devon, Juge, Nathalie

“…The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In…”
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Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent by Crost, Emmanuelle H, Tailford, Louise E, Le Gall, Gwenaelle, Fons, Michel, Henrissat, Bernard, Juge, Nathalie

“…Commensal bacteria often have an especially rich source of glycan-degrading enzymes which allow them to utilize undigested carbohydrates from the food or the…”
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Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation by Tailford, Louise E., Owen, C. David, Walshaw, John, Crost, Emmanuelle H., Hardy-Goddard, Jemma, Le Gall, Gwenaelle, de Vos, Willem M., Taylor, Garry L., Juge, Nathalie

“…The gastrointestinal mucus layer is colonized by a dense community of microbes catabolizing dietary and host carbohydrates during their expansion in the gut…”
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Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus by Owen, C. David, Tailford, Louise E., Monaco, Serena, Šuligoj, Tanja, Vaux, Laura, Lallement, Romane, Khedri, Zahra, Yu, Hai, Lecointe, Karine, Walshaw, John, Tribolo, Sandra, Horrex, Marc, Bell, Andrew, Chen, Xi, Taylor, Gary L., Varki, Ajit, Angulo, Jesus, Juge, Nathalie

“…Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an intramolecular trans -sialidase ( Rg NanH). Rg NanH…”
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Structural basis for adaptation of lactobacilli to gastrointestinal mucus by Etzold, Sabrina, Kober, Olivia I., MacKenzie, Donald A., Tailford, Louise E., Gunning, A. Patrick, Walshaw, John, Hemmings, Andrew M., Juge, Nathalie

“…Summary The mucus layer covering the gastrointestinal (GI) epithelium is critical in selecting and maintaining homeostatic interactions with our gut bacteria…”
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Insights into Plant Cell Wall Degradation from the Genome Sequence of the Soil Bacterium Cellvibrio japonicus by DEBOY, Robert T, MONGODIN, Emmanuel F, NELSON, Karen E, FOUTS, Derrick E, TAILFORD, Louise E, KHOURI, Hoda, EMERSON, Joanne B, MOHAMOUD, Yasmin, WATKINS, Kisha, HENRISSAT, Bernard, GILBERT, Harry J

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Crystal Structure of a Mucus-binding Protein Repeat Reveals an Unexpected Functional Immunoglobulin Binding Activity by MacKenzie, Donald A., Tailford, Louise E., Hemmings, Andrew M., Juge, Nathalie

“…Lactobacillus reuteri mucus-binding protein (MUB) is a cell-surface protein that is involved in bacterial interaction with mucus and colonization of the…”
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Genome Sequence of the Vertebrate Gut Symbiont Lactobacillus reuteri ATCC 53608 by HEAVENS, Darren, TAILFORD, Louise E, CROSSMAN, Lisa, JEFFERS, Faye, MACKENZIE, Donald A, CACCAMO, Mario, JUGE, Nathalie

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Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts by Monaco, Serena, Tailford, Louise E., Juge, Nathalie, Angulo, Jesus

“…Saturation transfer difference (STD) NMR spectroscopy is extensively used to obtain epitope maps of ligands binding to protein receptors, thereby revealing…”
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Multifrequency-STD NMR unveils the first Michaelis complex of an intramolecular trans-sialidase from Ruminococcus gnavus by Monaco, Serena, Tailford, Louise E., Bell, Andrew, Wallace, Matthew, Juge, Nathalie, Angulo, Jesús

“…[Display omitted] •RgNanH-GH33 is an intramolecular trans-sialidase expressed by the human gut symbiont Ruminococcus gnavus, to utilise intestinal sialylated…”
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Insights into the Molecular Determinants of Substrate Specificity in Glycoside Hydrolase Family 5 Revealed by the Crystal Structure and Kinetics of Cellvibrio mixtus Mannosidase 5A by Dias, Fernando M.V., Vincent, Florence, Pell, Gavin, Prates, José A.M., Centeno, Maria S.J., Tailford, Louise E., Ferreira, Luís M.A., Fontes, Carlos M.G.A., Davies, Gideon J., Gilbert, Harry J.

“…The enzymatic hydrolysis of the glycosidic bond is central to numerous biological processes. Glycoside hydrolases, which catalyze these reactions, are grouped…”
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Structural dissection and high-throughput screening of mannosylglycerate synthase by Davies, Gideon J, Flint, James, Taylor, Edward, Yang, Min, Bolam, David N, Tailford, Louise E, Martinez-Fleites, Carlos, Dodson, Eleanor J, Davis, Benjamin G, Gilbert, Harry J

“…The enzymatic transfer of activated mannose yields mannosides in glycoconjugates and oligo- and polysaccharides. Yet, despite its biological necessity, the…”
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The mucin-degradation strategy of Ruminococcus gnavus: The importance of intramolecular trans-sialidases by Crost, Emmanuelle H., Tailford, Louise E., Monestier, Marie, Swarbreck, David, Henrissat, Bernard, Crossman, Lisa C., Juge, Nathalie

“…We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is…”
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Mining the “glycocode”—exploring the spatial distribution of glycans in gastrointestinal mucin using force spectroscopy by Gunning, A. Patrick, Kirby, Andrew R., Fuell, Christine, Pin, Carmen, Tailford, Louise E., Juge, Nathalie

“…Mucins are the main components of the gastrointestinal mucus layer. Mucin glycosylation is critical to most intermolecular and intercellular interactions…”
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Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives by Monestier, Marie, Latousakis, Dimitrios, Bell, Andrew, Tribolo, Sandra, Tailford, Louise E., Colquhoun, Ian J., Le Gall, Gwenaelle, Yu, Hai, Chen, Xi, Rejzek, Martin, Dedola, Simone, Field, Robert A., Juge, Nathalie

“…Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases…”
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Structural and biochemical evidence for a boat-like transition state in β-mannosidases by Gilbert, Harry J, Davies, Gideon J, Tailford, Louise E, Offen, Wendy A, Smith, Nicola L, Dumon, Claire, Morland, Carl, Gratien, Julie, Heck, Marie-Pierre, Stick, Robert V, Blériot, Yves, Vasella, Andrea

“…Enzyme inhibition through mimicry of the transition state is a major area for the design of new therapeutic agents. Emerging evidence suggests that many…”
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Understanding How Diverse β-Mannanases Recognize Heterogeneous Substrates by Tailford, Louise E, Ducros, Valerie M.-A, Flint, James E, Roberts, Shirley M, Morland, Carl, Zechel, David L, Smith, Nicola, Bjo̷rnvad, Mads E, Borchert, Torben V, Wilson, Keith S, Davies, Gideon J, Gilbert, Harry J

“…The mechanism by which polysaccharide-hydrolyzing enzymes manifest specificity toward heterogeneous substrates, in which the sequence of sugars is variable, is…”
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Mannose Foraging by Bacteroides thetaiotaomicron: STRUCTURE AND SPECIFICITY OF THE β-MANNOSIDASE, BtMan2A by Tailford, Louise E, Money, Victoria A, Smith, Nicola L, Dumon, Claire, Davies, Gideon J, Gilbert, Harry J

“…The human colonic bacterium Bacteroides thetaiotaomicron, which plays an important role in maintaining human health, produces an extensive array of exo-acting…”
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Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts by Monaco, Serena, Tailford, Louise E., Juge, Nathalie, Angulo, Jesus

“…Saturation transfer difference (STD) NMR spectroscopy is extensively used to obtain epitope maps of ligands binding to protein receptors, thereby revealing…”
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Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase by Nielsen, Morten M., Suits, Michael D.L., Yang, Min, Barry, Conor S., Martinez-Fleites, Carlos, Tailford, Louise E., Flint, James E., Dumon, Claire, Davis, Benjamin G., Gilbert, Harry J., Davies, Gideon J.

“…The enzymatic transfer of the sugar mannose from activated sugar donors is central to the synthesis of a wide range of biologically significant polysaccharides…”
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