Search Results - "Taichman, Lorne B."

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin by Ghazizadeh, Soosan, Taichman, Lorne B.

“…Continuous renewal of the epidermis and its appendages throughout life depends on the proliferation of a distinct population of cells called stem cells. We…”
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Evidence for Keratinocyte Stem Cells in vitro: Long Term Engraftment and Persistence of Transgene Expression from Retrovirus-Transduced Keratinocytes by Kolodka, Taduesz M., Garlick, Jonathan A., Taichman, Lorne B.

“…Epidermis is renewed by a population of stem cells that have been defined in vivo by slow turnover, label retention, position in the epidermis, and enrichment…”
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Organization of Stem Cells and Their Progeny in Human Epidermis by Ghazizadeh, Soosan, Taichman, Lorne B.

“…Renewal of epidermis is achieved by an ordered replication of stem cells and transit amplifying cells followed by terminal differentiation. In mouse epidermis,…”
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Effect of TGF-β1 on Re-Epithelialization of Human Keratinocytes In Vitro: An Organotypic Model by Garlick, Jonathan A, Taichman, Lorne B

“…Transforming growth factor beta-1 (TGF-β1) has been shown to inhibit keratinocyte proliferation in vitro yet to stimulate wound healing in vivo. To explore…”
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Immune-mediated loss of transgene expression in skin: implications for cutaneous gene therapy by Ghazizadeh, Soosan, Kalish, Richard S, Taichman, Lorne B

“…A clearer understanding of the immune-mediated loss of transgene from cutaneous epithelium is necessary for development of effective clinical gene therapy…”
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A Partial Catalog of Proteins Secreted by Epidermal Keratinocytes in Culture by Katz, Anne B., Taichman, Lorne B.

“…Proteins secreted by epidermal keratinocytes are known to engage in functions other than those directly associated with barrier formation. We have used a…”
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Virus-mediated gene transfer for cutaneous gene therapy by Ghazizadeh, S, Taichman, L B

“…Cutaneous gene therapy offers unique opportunities and limitations in the use of viral vectors for corrective gene transfer. Skin presents a formidable barrier…”
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Lentivirus-mediated gene transfer to human epidermis by Ghazizadeh, Soosan, Katz, Anne B, Harrington, Robin, Taichman, Lorne B

“…For long-term cutaneous gene therapy, the therapeutic gene must be targeted to stem cells and be stably transmitted to and expressed in descendant cells…”
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Transduction of β3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin by KUBO, Miyoko, CLARK, Richard A. F, KATZ, Anne B, TAICHMAN, Lorne B, ZAISHUN JIN, YING ZHAO, MORIGUCHI, Takahiko

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Tissue- and Stratum-Specific Expression of the Human Involucrin Promoter in Transgenic Mice by Carroll, Joseph M., Albers, Kathryn M., Garlick, Jonathan A., Harrington, Robin, Taichman, Lorne B.

“…Involucrin is a marker of keratinocyte terminal differentiation and is expressed only in the suprabasal layers of stratified squamous epithelium. In a previous…”
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Systemic delivery of secreted protein by grafts of epidermal keratinocytes: prospects for keratinocyte gene therapy by Fenjves, E S, Smith, J, Zaradic, S, Taichman, L B

“…Grafts of autologous keratinocytes genetically altered to secrete a new gene product are a potential vehicle for gene therapy. To consider the feasibility of…”
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Retrovirus-Mediated Transduction of Cultured Epidermal Keratinocytes by Garlick, Jonathan A., Katz, Anne B., Fenjves, Elizabeth S., Taichman, Lorne B.

“…Retrovirus-mediated gene transfer is an efficient means of introducing and expressing exogenous gene(s) in many cell types including keratinocytes. However,…”
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Secretion of Apolipoprotein E by Basal Cells in Cultures of Epidermal Keratinocytes by Barra, Rose M., Fenjves, Elizabeth S., Taichman, Lorne B.

“…Recently it has been shown that apolipoprotein E (apoE) secreted by keratinocytes in transplanted epidermal grafts reaches the systemic circulation. In this…”
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Replication and persistence of HPV DNA in cultured cells derived from laryngeal papillomas by DiLorenzo, T P, Taichman, L B, Steinberg, B M

“…We have investigated the replication and persistence of human papillomavirus (HPV) type 6 and 11 DNA in cultured cells derived from laryngeal papillomas, with…”
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Transient Expression of a Transfected Gene in Cultured Epidermal Keratinocytes: Implications for Future Studies by Lee, Joseph I., Taichman, Lorne B.

“…We examine the effect of keratinocyte differentiation upon transient expression of a nonepithelial gene following DNA-mediated transfer. Cultures of primary…”
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Epithelium-specific Response of Cultured Keratinocytes to Infection with Adenovirus Type 2 by Aneskievich, Brian J., Taichman, Lorne B.

“…Adenoviruses are pathogenic for certain stratified squamous epithelia. The sites most frequently involved are the upper respiratory tract and oropharynx…”
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Analysis of Adenovirus Early and Late Gene Expression in Cultured Epidermal Keratinocytes by Aneskievich, Brian J, Lee, Joseph I, Taichman, Lorne B

“…Previous studies have shown that expression of adenovirus type 2 (Ad2) is restricted in epidermal keratinocytes in what appears to be a differentiation…”
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Kinetics of Withdrawal from the Cell Cycle in Cultured Human Epidermal Keratinocytes by Albers, Kathryn M., Taichman, Lorne B.

“…In keratinizing epithelia one of the earliest changes in the process of terminal differentiation is cessation of replication or withdrawal from the cell cycle…”
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Transduction of beta3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin by Kubo, Miyoko, Clark, Richard A F, Katz, Anne B, Taichman, Lorne B, Jin, Zaishun, Zhao, Ying, Moriguchi, Takahiko

“…alphavbeta3 is a multiligand integrin receptor that interacts with fibrinogen (FG), fibrin (FB), fibronectin (FN), vitronectin (VN), and denatured collagen. We…”
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Transduction of [beta]3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin by Kubo, Miyoko, Clark, Richard A F, Katz, Anne B, Taichman, Lorne B, Jin, Zaishun, Zhao, Ying, Moriguchi, Takahiko

“…αvβ3 is a multiligand integrin receptor that interacts with fibrinogen (FG), fibrin (FB), fibronectin (FN), vitronectin (VN), and denatured collagen. We…”
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