Search Results - "Tai, Kuninori"

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor by Tamanini, Emiliano, Miyamura, Shin, Buck, Ildiko M., Cons, Benjamin D., Dawson, Lee, East, Charlotte, Futamura, Takashi, Goto, Shintaro, Griffiths-Jones, Charlotte, Hashimoto, Tetsuya, Heightman, Tom D., Ishikawa, Shunpei, Ito, Hideki, Kaneko, Yosuke, Kawato, Tatsuya, Kondo, Kazumi, Kurihara, Naoki, McCarthy, James M., Mori, Yukiko, Nagase, Tsuyoshi, Nakaishi, Yuichiro, Reeks, Judith, Sato, Akimasa, Schöpf, Patrick, Tai, Kuninori, Tamai, Taichi, Tisi, Dominic, Woolford, Alison J.-A.

“…Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based…”
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Development of Photoredox Cross-Electrophile Coupling of Strained Heterocycles with Aryl Bromides Using High-Throughput Experimentation for Library Construction by Mori, Yukiko, Hayashi, Mutsuyo, Sato, Ryuma, Tai, Kuninori, Nagase, Tsuyoshi

“…Microscale high-throughput experimentation was used to develop a photoredox-assisted reductive cross-coupling reaction of aryl halides with strained aliphatic…”
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Asymmetric α-Alkylation of α-Amino Esters Using Pyridoxal Derivatives Having a Chiral Ansa-Structure and a Chiral Ionophore Function: a Novel Example of Double Asymmetric Induction by Miyashita, Kazuyuki, Miyabe, Hideto, Tai, Kuninori, Iwaki, Hiroshi, Imanishi, Takeshi

“…Stereoselective alkylation of aldimines, prepared from α-amino esters and a pyridoxal model having a chiral ansa-structure and an ethoxyethoxy group at C-3,…”
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Regio- and stereoselective α-alkylation of N-terminal amino acid residue of peptides using a pyridoxal model compound with a chiral ansa-structure by Miyashita, Kazuyuki, Iwaki, Hiroshi, Tai, Kuninori, Murafuji, Hidenobu, Sasaki, Naoko, Imanishi, Takeshi

“…Regio- and stereoselective α-alkylation of N-terminal amino acid residue of peptides was achieved by Li +-mediated alkylation of aldimines prepared from the…”
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Chiral environment specifically induced by metal ion: Asymmetric α-alkylation of α-amino esters using pyridoxal derivatives having a chiral ionophore function by Miyashita, Kazuyuki, Miyabe, Hideto, Tai, Kuninori, Kurozumi, Chiaki, Iwaki, Hiroshi, Imanishi, Takeshi

“…Stereoselective alkylation of aldimines, prepared from α-amino esters and pyridoxal models having an ionophoric side-chain composed of a chiral glycerol…”
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α-alkylation of α-amino esters by using a pyridoxal model compound having a Li +-ionophore character by Miyashita, Kazuyuki, Miyabe, Hideto, Kurozumi, Chiaki, Tai, Kuninori, Imanishi, Takeshi

“…Synthesis of α,α-dialkyl-α-amino esters by α-alkylation of aldimines prepared from a novel pyridoxal model compound was studied. The α-alkylation of the…”
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