Search Results - "Tai, H L"

Between the primate and ‘reptilian’ brain: Rodent models demonstrate the role of corticostriatal circuits in decision making by Lee, A.M, Tai, L.-H, Zador, A, Wilbrecht, L

“…Highlights • Rodent models of decision making. • Evolutionary elaboration of corticostriatal connectivity. • The dorsal striatum as a “ballot box” for action…”
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Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome by Belanger, S, Tai, L-H, Anderson, S K, Makrigiannis, A P

“…The mouse Ly49 and human killer cell immunoglobulin-like receptors ( KIR) gene clusters encode activating and inhibitory class I MHC receptors on natural…”
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Thiopurine S-methyltransferase deficiency : Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians by HUNG-LIANG TAI, KRYNETSKI, E. Y, YATES, C. R, LOENNECHEN, T, FESSING, M. Y, KRYNETSKAIA, N. F, EVANS, W. E

“…The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated…”
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Molecular diagnosis of thiopurine S-methyltransferase deficiency : Genetic basis for azathioprine and mercaptopurine intolerance by YATES, C. R, KRYNETSKI, E. Y, LOENNECHEN, T, FESSING, M. Y, TAI, H.-L, PUI, C.-H, RELLING, M. V, EVANS, W. E

“…Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic…”
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Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen by Lal, Ritu, Sukbuntherng, Juthamas, Tai, Ezra H L, Upadhyay, Shubhra, Yao, Fenmei, Warren, Mark S, Luo, Wendy, Bu, Lin, Nguyen, Son, Zamora, Jeanelle, Peng, Ge, Dias, Tracy, Bao, Ying, Ludwikow, Maria, Phan, Thu, Scheuerman, Randall A, Yan, Hui, Gao, Mark, Wu, Quincey Q, Annamalai, Thamil, Raillard, Stephen P, Koller, Kerry, Gallop, Mark A, Cundy, Kenneth C

“…Baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the…”
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Recurrent hypoglycaemia in a patient with metastatic pancreatic carcinoma by Ma, Ronald C W, Lo, Raymond S K, Tai, Morris H L, Chan, Juliana C N, Chow, Chun Chung, Woo, Jean L F

“…The patient's recurrent hypoglycaemia was found to be due to non-islet cell tumour hypoglycaemia…”
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Tissue Factor Pathway Inhibitor Gene Polymorphism −33T → C Predicts Improved Disease-Free Survival in Colorectal Cancer by Bazzarelli, A. K., Scheer, A. S., Tai, L. H., Seth, R., de Souza, C. Tanese, Petrcich, W., Jonker, D. J., Maroun, J. A., Carrier, M., Auer, R. C.

“…Background Tissue factor pathway inhibitor (TFPI) is an anticoagulant with antimetastatic properties. The homozygous CC polymorphism of TFPI (−33T → C) is…”
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Translational control of the innate immune response through IRF-7 by Jaramillo, Maritza, Rong, Liwei, Martineau, Yvan, Costa-Mattioli, Mauro, Svitkin, Yuri V, Tai, Lee-Hwa, Sonenberg, Nahum, Bell, John C, Colina, Rodney, Breitbach, Caroline J, Makrigiannis, Andrew P, Dowling, Ryan J. O, Larsson, Ola

“…Transcriptional activation of cytokines, such as type-I interferons (interferon (IFN)-α and IFN-β), constitutes the first line of antiviral defence. Here we…”
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Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of D4T-phenyl methoxyalaninyl phosphate derivatives by Venkatachalam, T.K, Tai, Hung-Liang, Vig, Rakesh, Chen, Chun-Lin, Jan, Shyi-Tai, Uckun, Fatih M

“…d4T-5′-[ p-Bromophenyl methoxyalaninyl phosphate] (d4T-pBPMAP), a novel phenyl phosphate derivative of 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T) that has an…”
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Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction by DRAHUSHUK, A. T, MCGARRIGLE, B. P, TAI, H.-L, KITAREEWAN, S, GOLDSTEIN, J. A, OLSON, J. R

“…The utilization of precision-cut liver slices in dynamic organ culture as an in vitro model was validated by comparing the induction of the biomarker responses…”
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Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity by CHEN, C.-L, TAI, H.-L, ZHU, D.-M, UCKUN, F. M

“…To examine the pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with potent antileukemic activity. HPLC-based…”
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Optimal treatment for distal ureteral calculi: extracorporeal shockwave lithotripsy versus ureteroscopy by Chang, C P, Huang, S H, Tai, H L, Wang, B F, Yen, M Y, Huang, K H, Jiang, H J, Lin, J

“…The optimal treatment for distal ureteral calculi remains controversial. We present data from our institution to compare the efficacy of extracorporeal…”
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No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients by Tang, Nelson L. S., Chow, C. C., Ko, Gary T. C., Tai, Morris H. L., Kwok, Rachel, Yao, X. Q., Cockram, Clive S.

“…Summary objectives  Mutation in KCNE3 gene (Isk‐related family potassium voltage‐gated channel member 3 gene) was recently associated with the aetiology of…”
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Xanthogranulomatous cystitis associated with anaerobic bacterial infection by Tai, H L, Chen, C C, Yeh, K T

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AZT-5′-(p-Bromophenyl Methoxyalaninyl Phosphate) as a Potent and Non-Toxic Anti-Human Immunodeficiency Virus Agent by Jan, Shyi-Tai, Zhu, Z, Tai, H-L, Shih, Mei-Jue, Venkatachalam, TK, Uckun, Fatih M

“…The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing…”
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Remodeling of the pancreatic tumor microenvironment with oncolytic virotherapy by Amhis, N., Tai, L.-H., Collin, Y.

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Remodeling of the pancreatic tumor microenvironment with oncolytic virotherapy by Amhis, N., Collin, Y., Tai, L.-H.

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Enhanced Proteolysis of Thiopurine S-methyltransferase (TPMT) Encoded by Mutant Alleles in Humans (TPMT3A, TPMT2): Mechanisms for the Genetic Polymorphism of TPMT Activity by Tai, Hung-Liang, Krynetski, Eugene Y., Schuetz, Erin G., Yanishevski, Yuri, Evans, William E.

“…TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and…”
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ATP stimulates Ca2+ release from a rapidly exchanging pool in cultured rat epididymal cells by Leung, A Y, Tai, H L, Wong, P Y

“…A study was carried out to investigate an ATP-sensitive Ca2+ pool in rat epididymal cells and its role in transepithelial Cl- secretion. In normal buffered…”
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Technology evaluation: Valspodar, Novartis AG by Tai, H L

“…Valspodar (PSC-833) is a derivative of cyclosporin but devoid of the immunosuppressive and nephrotoxic properties seen in cyclosporin A. It exhibited high…”
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