Search Results - "Tahtamouni, Lubna H"

Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration by Bamburg, James, Minamide, Laurie, Wiggan, O’Neil, Tahtamouni, Lubna, Kuhn, Thomas

“…Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function…”
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Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors by Shihab, Wurood A, Kubba, Ammar A Razzak, Tahtamouni, Lubna H, Saleh, Khaled M, AlSakhen, Mai F, Kanaan, Sana I, Saleh, Abdulrahman M, Yasin, Salem R

“…Allosteric inhibition of EGFR tyrosine kinase (TK) is currently among the most attractive approaches for designing and developing anti-cancer drugs to avoid…”
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Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety by Alsaad, Hiba, Kubba, Ammar, Tahtamouni, Lubna H, Hamzah, Ali H

“…A series of 1,2,4 triazole derivatives (H7-12) have been synthesized by reacting an excess of hydrazine hydrate with carbothioamide derivatives (H1-6). The…”
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New Niflumic Acid Derivatives as EGFR Inhibitors: Design, Synthesis, In silico Studies, and Anti-proliferative Assessment by Yaseen, Yahya S, Mahmood, Ammar A R, Abbas, Ali H, Shihab, Wurood A, Tahtamouni, Lubna H

“…1,3,4-oxadizole and pyrazole derivatives are very important scaffolds for medicinal chemistry. A literature survey revealed that they possess a wide spectrum…”
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Synthesis and Cytotoxic Activity of Some New Bipyrazole Derivatives by A. Salameh, Bader, A. Abu-Safieh, Kayed, S. AL-Aqrabawi, Islam, Alsoubani, Fatima, H. Tahtamouni, Lubna

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A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity by Abbas, Ali H, Mahmood, Ammar A. Razzak, Tahtamouni, Lubna H, Al-Mazaydeh, Zainab A, Rammaha, Majdoleen S, Alsoubani, Fatima, Al-bayati, Rheda I

“…Thirteen new derivatives of picolinic acid ( 4–7 ) were designed and synthesized from the starting parent molecule, picolinic acid. The new compounds were…”
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Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology by Tahtamouni, Lubna H, Alderfer, Sydney A, Kuhn, Thomas B, Minamide, Laurie S, Chanda, Soham, Ruff, Michael R, Bamburg, James R

“…Cofilactin rod pathology, which can initiate synapse loss, has been extensively studied in rodent neurons, hippocampal slices, and in vivo mouse models of…”
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Chemokine Receptor Antagonists Prevent and Reverse Cofilin-Actin Rod Pathology and Protect Synapses in Cultured Rodent and Human iPSC-Derived Neurons by Kuhn, Thomas B, Minamide, Laurie S, Tahtamouni, Lubna H, Alderfer, Sydney A, Walsh, Keifer P, Shaw, Alisa E, Yanouri, Omar, Haigler, Henry J, Ruff, Michael R, Bamburg, James R

“…Synapse loss is the principal cause of cognitive decline in Alzheimer's disease (AD) and related disorders (ADRD). Synapse development depends on the intricate…”
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Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives by Al-Bayati, Ammar I, Mahmood, Ammar A. Razzak, Al-Mazaydeh, Zainab A, Rammaha, Majdoleen S, Al-bayati, Rheda I, Alsoubani, Fatima, Tahtamouni, Lubna H

“…Novel compounds (6–10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, 1 HNMR and CHNS. Their cytotoxic effect was evaluated by MTT…”
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Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia by Kile, Benjamin T., Panopoulos, Athanasia D., Stirzaker, Roslynn A., Hacking, Douglas F., Tahtamouni, Lubna H., Willson, Tracy A., Mielke, Lisa A., Henley, Katya J., Zhang, Jian-Guo, Wicks, Ian P., Stevenson, William S., Nurden, Paquita, Watowich, Stephanie S., Justice, Monica J.

“…A pivotal mediator of actin dynamics is the protein cofilin, which promotes filament severing and depolymerization, facilitating the breakdown of existing…”
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Feasibility of collecting umbilical cord blood in jordan and the effect of maternal and neonatal factors on hematopoietic stem cell content by Hussein, Ayad Ahmed, Bawadi, Randa M, Tahtamouni, Lubna H, Frangoul, Haydar, Elkarmi, Ali Z

“…Cord blood transplant is an accepted treatment for many malignant and non-malignant diseases. We sought to determine the feasibility of collecting cord blood…”
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Anti-Angiogenic and Anti-Proliferative Activity of 4-2-(5-bromo-1H-indol-2-carbonyl)-N-(4-methoxyphenyl) Hydrazine-1-carbothioamide: Ex-vivo and in vitro Study by Aldhalmi, Ahmed K, Sahib, Hayder B, Hassan, Omeed M, Mahmood, Ammar A Razzak, Tahtamouni, Lubna H

“…Angiogenesis, the formation of new blood vessels, stimulates tumor growth and spread by delivering oxygen and nutrients, and is a key component of metastasis…”
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Vitamin B12 enhances the antitumor activity of 1,25-dihydroxyvitamin D3 via activation of caspases and targeting actin cytoskeleton by Atoum, Manar F, Alzoughool, Foad E, Al-Mazaydeh, Zainab A, Rammaha, Majdoleen S, Tahtamouni, Lubna H

“…1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is an effective anticancer agent, and when combined with other agents it shows superior activities. Vitamin B12 has been…”
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New tolfenamic acid derivatives with hydrazine-1-carbothioamide and 1,3,4-oxadiazole moieties targeting VEGFR: synthesis, in silico studies, and in vitro anticancer assessment by Mehihi, Abbas A. Ridha, Kubba, Ammar A. Razzak, Shihab, Wurood A., Tahtamouni, Lubna H.

“…VEGFR-2 is required for tumor angiogenesis and metastasis. As a cancer therapeutic strategy, blocking VEGFR-2 signaling pathway has gained much interest. Our…”
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Biological activity and apoptotic signaling pathway of C11-functionalized cephalostatin 1 analogues by Nawasreh, Mansour M., Alzyoud, Elham I., Al-Mazaydeh, Zainab A., Rammaha, Majdoleen S., Yasin, Salem R., Tahtamouni, Lubna H.

“…[Display omitted] •Cephalostatin 1 analogues CA5 and CA6 were cytotoxic against three cancer cell lines.•The 12′β-OH and 12-carbonyl groups are required to…”
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New Combretastatin Analogs as Anticancer Agents: Design, Synthesis, Microtubules Polymerization Inhibition, and Molecular Docking Studies by Abdul Hussein, Shaker A., Razzak Mahmood, Ammar A., Tahtamouni, Lubna H., Balakit, Asim A., Yaseen, Yahya S., Al‐Hasani, Rehab A.

“…A new series of 4‐(4‐methoxyphenyl)‐5‐(3,4,5‐trimethoxyphenyl)‐4H‐1,2,4‐triazole‐3‐thiol derivatives were synthesized as analogs for the anticancer drug…”
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New Indole‐6‐Carboxylic Acid Derivatives as Multi‐Target Antiproliferative Agents: Synthesis, in Silico Studies, and Cytotoxicity Evaluation by Allawi, Mustafa M., Mahmood, Ammar A. Razzak, Tahtamouni, Lubna H., AlSakhen, Mai F., Kanaan, Sana I., Saleh, Khaled M., Yasin, Salem R.

“…Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are commonly overexpressed in cancers making them appealing…”
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Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3‐phenoxybenzoic acid as VEGFR‐2 inhibitors by Heriz, Mohammad H., Mahmood, Ammar A. R., Yasin, Salem R., Saleh, Khaled M., AlSakhen, Mai F., Kanaan, Sana I., Himsawi, Nisreen, Saleh, Abdulrahman M., Tahtamouni, Lubna H.

“…Current chemotherapeutic agents have several limitations, including lack of selectivity, the development of undesirable side effects, and chemoresistance. As a…”
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Front Cover: New Indole‐6‐Carboxylic Acid Derivatives as Multi‐Target Antiproliferative Agents: Synthesis, in Silico Studies, and Cytotoxicity Evaluation (Chem. Biodiversity 2/2024) by Allawi, Mustafa M., Mahmood, Ammar A. Razzak, Tahtamouni, Lubna H., AlSakhen, Mai F., Kanaan, Sana I., Saleh, Khaled M., Yasin, Salem R.

“…Front Cover. EGFR and VEGFR‐2 are commonly overexpressed in cancers making them attractive targets for cancer therapy. Hydrazone and oxadiazole derivatives of…”
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Anti-proliferation evaluation of new derivatives of indole-6-carboxylate ester as receptor tyrosine kinase inhibitors by Allawi, Mustafa M, Razzak Mahmood, Ammar A, Tahtamouni, Lubna H, Saleh, Abdulrahman M, Kanaan, Sana I, Saleh, Khaled M, AlSakhen, Mai F, Himsawi, Nisreen, Yasin, Salem R

“…The main goal was to create two new groups of indole derivatives, hydrazine-1-carbothioamide ( and ) and oxadiazole ( , and ) that target EGFR ( , , ) or…”
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