Search Results - "Tahrani, A."

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus by Tahrani, Abd A., Barnett, Anthony H., Bailey, Clifford J.

“…Key Points Greater understanding of the complex and multifactorial pathogenesis of type 2 diabetes mellitus (T2DM) has informed the development of several new…”
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Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments by Toulis, Konstantinos A., Nirantharakumar, Krishnarajah, Pourzitaki, Chrysa, Barnett, Anthony H., Tahrani, Abd A.

“…Increased hepatic glucose output, the primary liver dysregulation associated with Type 2 diabetes mellitus (T2DM), is not directly or effectively targeted by…”
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Obesity and COVID-19: a call for action from people living with obesity by Le Brocq, S, Clare, K, Bryant, M, Roberts, K, Tahrani, AA

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Reduced physical activity in young and older adults: metabolic and musculoskeletal implications by Bowden Davies, Kelly A., Pickles, Samuel, Sprung, Victoria S., Kemp, Graham J., Alam, Uazman, Moore, Daniel R., Tahrani, Abd A., Cuthbertson, Daniel J.

“…Background: Although the health benefits of regular physical activity and exercise are well established and have been incorporated into national public health…”
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Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial by Ajjan, R A, Hensor, E M A, Del Galdo, F, Shams, K, Abbas, A, Fairclough, R J, Webber, L, Pegg, L, Freeman, A, Taylor, A E, Arlt, W, Morgan, A W, Tahrani, A A, Stewart, P M, Russell, D A, Tiganescu, A

“…Background Chronic wounds (e.g. diabetic foot ulcers) reduce the quality of life, yet treatments remain limited. Glucocorticoids (activated by the enzyme…”
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Management of type 2 diabetes: new and future developments in treatment by Tahrani, Abd A, MD, Bailey, Clifford J, Prof, Del Prato, Stefano, MD, Barnett, Anthony H, Prof

“…Summary The increasing prevalence, variable pathogenesis, progressive natural history, and complications of type 2 diabetes emphasise the urgent need for new…”
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Obesity Without Metabolic Abnormality and Incident CKD: A Population-Based British Cohort Study by Wang, Jingya, Niratharakumar, Krishnarajah, Gokhale, Krishna, Tahrani, Abd A., Taverner, Tom, Thomas, G. Neil, Dasgupta, Indranil

“…Metabolically healthy obesity (obesity without any metabolic abnormality) is not considered to be associated with increased risk of morbidity and mortality. We…”
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Impact of bariatric surgery on cardiovascular outcomes and mortality: a population‐based cohort study by Singh, P., Subramanian, A., Adderley, N., Gokhale, K., Singhal, R., Bellary, S., Nirantharakumar, K., Tahrani, A. A.

“…Background Cohort studies have shown that bariatric surgery may reduce the incidence of and mortality from cardiovascular disease (CVD), but studies using…”
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Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives by Fisher, Victoria L, Tahrani, Abd A

“…Cardiac autonomic neuropathy (CAN) is a common and often-underdiagnosed complication of diabetes mellitus (DM). CAN is associated with increased mortality,…”
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Novel therapeutics for type 2 diabetes: insulin resistance by Altaf, Q.-A., Barnett, A. H, Tahrani, A. A.

“…Insulin resistance (IR) plays an important role in the pathogenesis of type 2 diabetes (T2D) and cardiovascular disease. Hence improving IR is a major target…”
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Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): A United Kingdom population-based cohort study using the health improvement network (THIN) by Vusirikala, A, Thomas, T, Bhala, N, Tahrani, A A, Thomas, G N, Nirantharakumar, K

“…With the obesity epidemic reaching crisis levels, there has been attention around those who may be resilient to the effects of obesity, termed metabolically…”
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Systematic Review and Meta-Analysis of Outcomes After Revisional Bariatric Surgery Following a Failed Adjustable Gastric Band by Sharples, Alistair J., Charalampakis, Vasileios, Daskalakis, Markos, Tahrani, Abd A., Singhal, Rishi

“…Introduction Laparoscopic adjustable gastric band (LAGB)-related complications have been reported in significant numbers of patients often leading to band…”
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SGLT inhibitors in management of diabetes by Tahrani, Abd A, MD, Barnett, Anthony H, Prof, Bailey, Clifford J, Prof

“…Summary The two main sodium–glucose cotransporters (SGLTs), SGLT1 and SGLT2, provide new therapeutic targets to reduce hyperglycaemia in patients with…”
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Cardiac autonomic neuropathy in patients with diabetes mellitus by Dimitropoulos, Gerasimos, Tahrani, Abd A, Stevens, Martin J

“…Cardiac autonomic neuropathy(CAN)is an often overlooked and common complication of diabetes mellitus.CAN is associated with increased cardiovascular morbidity…”
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Exploring the awareness, attitudes, and actions (AAA) of UK adults at high risk of severe illness from COVID-19 by Flint, Stuart W, Brown, Adrian, Sanders, George, Tahrani, Abd A

“…Background People at high risk of severe illness from COVID-19 have experienced greater restrictions during the pandemic, yet there is a paucity of research…”
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Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning by Nielsen, Rikke Linnemann, Monfeuga, Thomas, Kitchen, Robert R., Egerod, Line, Leal, Luis G., Schreyer, August Thomas Hjortshøj, Gade, Frederik Steensgaard, Sun, Carol, Helenius, Marianne, Simonsen, Lotte, Willert, Marianne, Tahrani, Abd A., McVey, Zahra, Gupta, Ramneek

“…Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients’ lives. However, our understanding of biomarkers driving OA risk remains…”
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Obstructive sleep apnoea in women with idiopathic intracranial hypertension: a sub-study of the idiopathic intracranial hypertension weight randomised controlled trial (IIH: WT) by Yiangou, Andreas, Mitchell, James L., Nicholls, Matthew, Chong, Yu Jeat, Vijay, Vivek, Wakerley, Benjamin R., Lavery, Gareth G., Tahrani, Abd A., Mollan, Susan P., Sinclair, Alexandra J.

“…Objective Obesity is a risk factor for idiopathic intracranial hypertension (IIH) and obstructive sleep apnoea (OSA). We aimed to determine the prevalence of…”
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Cardiopulmonary outcomes in people with impaired lung function: the role of metabolic syndrome by Sadeghimakki, Roham, Tahrani, Abd A

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Author response to: Comment on: Impact of bariatric surgery on cardiovascular outcomes and mortality: a population‐based cohort study by Adderley, N., Singh, P., Tahrani, A. A., Nirantharakumar, K.

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Serum testosterone, sex hormone‐binding globulin and sex‐specific risk of incident type 2 diabetes in a retrospective primary care cohort by O’Reilly, Michael W., Glisic, Marija, Kumarendran, Balachandran, Subramanian, Anuradhaa, Manolopoulos, Konstantinos N., Tahrani, Abd A., Keerthy, Deepi, Muka, Taulant, Toulis, Konstantinos A., Hanif, Wasim, Thomas, G. Neil, Franco, Oscar H., Arlt, Wiebke, Nirantharakumar, Krishnarajah

“…Summary Objective Previous studies suggest that androgens have a sexually dimorphic impact on metabolic dysfunction. However, the sex‐specific link between…”
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