Evaluation of toxicological and antimicrobial activity of lavender and immortelle essential oils

Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using n...

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Published in:	Drug and chemical toxicology (New York, N.Y. 1978) Vol. 44; no. 2; pp. 190 - 197
Main Authors:	Mesic, Aner, Mahmutović-Dizdarević, Irma, Tahirović, Emina, Durmišević, Irma, Eminovic, Izet, Jerković-Mujkić, Anesa, Bešta-Gajević, Renata
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 04-03-2021
Subjects:	Allium cepa assay antimicrobial activity Cyto/genotoxic effects human lymphocyte culture immortelle lavender Allium cepa assay immortelle Cyto/genotoxic effects antimicrobial activity human lymphocyte culture lavender
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Summary:	Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bacteria and fungi. Our results for lavender and immortelle EOs showed that the frequency of chromosome aberrations (CAs) was increased in comparison with controls. For both oils, increased frequency of apoptosis for all concentrations, as well as the frequency of necrosis (0.10/0.30 µl/ml for lavender/immortelle, respectively) was demonstrated. In human lymphocytes, differences for minute fragments between immortelle oil (0.10 µl/ml) and controls were observed. Increased frequency of apoptosis was detected for immortelle oil (0.20 µl/ml), while both oils (0.20; 0.30 µl/ml lavender, and immortelle at all concentrations) induced higher frequency of necrosis in comparison with controls. Lavender EO was effective against all tested Gram-positive and Gram-negative bacteria, while immortelle EO inhibited only Gram-positive bacteria. Both oils exhibited antifungal effect. Our results demonstrated that lavender and immortelle EOs showed cyto/genotoxic effects in both, plant and human cells, as well as antimicrobial properties. Further studies are needed to strengthen these findings.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0148-0545 1525-6014
DOI:	10.1080/01480545.2018.1538234