Dried plum diet protects from bone loss caused by ionizing radiation

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bo...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 21343
Main Authors:	Schreurs, A.-S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., Globus, R. K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11-02-2016 Nature Publishing Group
Subjects:	13/100 631/136/815/816 631/250/808 631/443/63 64/60 692/700/565/485 Acids Animals Antioxidants Atoms & subatomic particles bone Bone loss Bone remodeling Bone resorption Bone Resorption - metabolism Bone Resorption - pathology Bone Resorption - prevention & control Cancellous bone Cosmic rays Cytokines Diet Dietary Supplements Dihydrolipoic acid Drug dosages Food Fruit Gamma rays Gamma Rays - adverse effects Gene expression Gene Expression Regulation - radiation effects Humanities and Social Sciences Ibuprofen Inflammation Ionizing radiation Ions Irradiation Male Mice multidisciplinary Nonsteroidal anti-inflammatory drugs Nutrition research Occupational exposure Osteoclasts osteoimmunology Photons Protons Prunus domestica Radiation Injuries, Experimental - metabolism Radiation Injuries, Experimental - pathology Radiation Injuries, Experimental - prevention & control Radiation therapy RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT radiotherapy Science Science (multidisciplinary) targeted bone remodelling TRANCE protein Transcription factors Tumor necrosis factor
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Summary:	Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or anti-inflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption ( Nfe2l2, Rankl, Mcp1, Opg, TNF-α ) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Thus, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 SC0001507 USDOE Office of Science (SC), Biological and Environmental Research (BER)
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep21343