Search Results - "Taher Darreh-Shori"

Fibrillar β‐amyloid 1‐42 alters cytokine secretion, cholinergic signalling and neuronal differentiation by Malmsten, Linn, Vijayaraghavan, Swetha, Hovatta, Outi, Marutle, Amelia, Darreh‐Shori, Taher

“…Adult neurogenesis is impaired by inflammatory processes, which are linked to altered cholinergic signalling and cognitive decline in Alzheimer's disease. In…”
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DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase by Kumar, Amit, Darreh-Shori, Taher

“…Dimethyl sulfoxide (DMSO) is the most common organic solvent used in biochemical and cellular assays during drug discovery programs. Despite its wide use, the…”
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Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme—A plausible missing link for their association with incidence of dementia by Kumar, Rajnish, Kumar, Amit, Nordberg, Agneta, Långström, Bengt, Darreh‐Shori, Taher

“…Introduction Several pharmacoepidemiological studies indicate that proton pump inhibitors (PPIs) significantly increase the risk of dementia. Yet, the…”
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Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling by Baidya, Anurag Tk, Kumar, Amit, Kumar, Rajnish, Darreh-Shori, Taher

“…The native function of amyloid-β (Aβ) peptides is still unexplored. However, several recent reports suggest a prominent role of Aβ peptides in acetylcholine…”
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A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease by Nordberg, Agneta, Ballard, Clive, Bullock, Roger, Darreh-Shori, Taher, Somogyi, Monique

“…To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and neurologic conditions, such as Alzheimer's disease (AD). The rationale for…”
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Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening by Kumar, Rajnish, Kumar, Amit, Långström, Bengt, Darreh-Shori, Taher

“…Alzheimer disease and related dementias are major challenges, demanding urgent needs for earliest possible diagnosis to optimize the success rate in finding…”
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CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment by Karami, Azadeh, Darreh-Shori, Taher, Schultzberg, Marianne, Eriksdotter, Maria

“…Alzheimer's disease (AD) is the most prevalent form of dementia with symptoms of deteriorating cognitive functions and memory loss, partially as a result of a…”
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NOVEL LIGANDS OF CHOLINE ACETYLTRANSFERASE AND CHOLINESTERASES: DRUG-REPURPOSING STRATEGIES AND IDENTIFICATION OF POTENTIAL PET TRACERS AS IN VIVO BIOMARKERS by Kumar, Amit, Kumar, Rajnish, Darreh-Shori, Taher

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Functional Glial Activation Mediates Phenotypic Effects of APOEɛ4 and Sex in Alzheimer’s Disease by Lane, Roger M, Li, Dan, Darreh-Shori, Taher

“…Background: This study examined the impact of apolipoprotein ɛ4 (APOEɛ4) allele frequency and sex on the phenotype of Alzheimer’s disease (AD). Methods: This…”
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Changes in neuromuscular structure and functions of human colon during ageing are region-dependent by Broad, John, Kung, Victor W S, Palmer, Alexandra, Elahi, Shezan, Karami, Azadeh, Darreh-Shori, Taher, Ahmed, Shafi, Thaha, Mohamed Adhnan, Carroll, Rebecca, Chin-Aleong, Joanne, Martin, Joanne E, Saffrey, M Jill, Knowles, Charles H, Sanger, Gareth John

“…To determine if human colonic neuromuscular functions decline with increasing age. Looking for non-specific changes in neuromuscular function, a standard burst…”
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Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain by Darreh-Shori, Taher, Rezaeianyazdi, Sareh, Lana, Erica, Mitra, Sumonto, Gellerbring, Anna, Karami, Azadeh, Bogdanovic, Nenad, Lithner, Christina Unger, Winblad, Bengt, Behbahani, Homira

“…OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy,…”
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Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions by Teitsdottir, Unnur D, Jonsdottir, Maria K, Lund, Sigrun H, Darreh-Shori, Taher, Snaedal, Jon, Petersen, Petur H

“…Abstract Background Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer’s disease…”
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Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway by Vijayaraghavan, Swetha, Karami, Azadeh, Aeinehband, Shahin, Behbahani, Homira, Grandien, Alf, Nilsson, Bo, Ekdahl, Kristina N, Lindblom, Rickard P F, Piehl, Fredrik, Darreh-Shori, Taher

“…Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable cells, such as endothelia, microglia, astrocytes and lymphocytes in…”
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Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis by Aeinehband, Shahin, Lindblom, Rickard P F, Al Nimer, Faiez, Vijayaraghavan, Swetha, Sandholm, Kerstin, Khademi, Mohsen, Olsson, Tomas, Nilsson, Bo, Ekdahl, Kristina Nilsson, Darreh-Shori, Taher, Piehl, Fredrik

“…Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent…”
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Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to AppNL−G−F knock-in Alzheimer mice by Tambaro, Simone, Mitra, Sumonto, Gera, Ruchi, Linderoth, Bengt, Wahlberg, Lars U, Darreh-Shori, Taher, Behbahani, Homira, Nilsson, Per, Eriksdotter, Maria

“…Abstract Background Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against…”
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Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers by Lane, Roger M, Darreh-Shori, Taher, Junge, Candice, Li, Dan, Yang, Qingqing, Edwards, Amanda L, Graham, Danielle L, Moore, Katrina, Mummery, Catherine J

“…The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in…”
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Repurposing Duloxetine as a Potent Butyrylcholinesterase Inhibitor: Potential Cholinergic Enhancing Benefits for Elderly Individuals with Depression and Cognitive Impairment by Darreh-Shori, Taher, Baidya, Anurag T. K., Brouwer, Medea, Kumar, Amit, Kumar, Rajnish

“…Despite the advent of new treatment strategies, cholinesterase inhibitors (ChEIs) are still the go-to treatment for dementia disorders. ChEIs act by inhibiting…”
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Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas by Sinclair, Lindsey Isla, Kumar, Amit, Darreh-Shori, Taher, Love, Seth

“…Up to 20% of patients with AD experience hallucinations. The pathological substrate is not known. Visual hallucinations (VH) are more common in dementia with…”
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Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers by Mitra, Sumonto, Turconi, Giorgio, Darreh-Shori, Taher, Mätlik, Kärt, Aquilino, Matilde, Eriksdotter, Maria, Andressoo, Jaan-Olle

“…Gradual decline in cholinergic transmission and cognitive function occurs during normal aging, whereas pathological loss of cholinergic function is a hallmark…”
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CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease by Karami, Azadeh, Eriksdotter, Maria, Kadir, Ahmadul, Almkvist, Ove, Nordberg, Agneta, Darreh-Shori, Taher

“…Alzheimer’s disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by…”
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