Search Results - "Tahar, Bouceba"
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Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent
Published in PloS one (20-03-2017)“…Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens. In contrast to bacteria, protozoan parasites, such as Leishmania, were little…”
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The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals
Published in PLoS pathogens (01-12-2020)“…The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating…”
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Laminin Receptor Involvement in the Anti-angiogenic Activity of Pigment Epithelium-derived Factor
Published in The Journal of biological chemistry (17-04-2009)“…Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic, anti-oxidative, and anti-inflammatory properties. It is also one of…”
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Isotype modulates epitope specificity, affinity, and antiviral activities of anti–HIV-1 human broadly neutralizing 2F5 antibody
Published in Proceedings of the National Academy of Sciences - PNAS (31-07-2012)“…The constant heavy chain (CH1) domain affects antibody affinity and fine specificity, challenging the paradigm that only variable regions contribute to antigen…”
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Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1
Published in International journal of molecular sciences (30-06-2020)“…Salicylic acid (SA) has an essential role in the responses of plants to pathogens. SA initiates defence signalling via binding to proteins. NPR1 is a…”
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Endocannabinoid regulation of inward rectifier potassium (Kir) channels
Published in Frontiers in pharmacology (26-08-2024)“…The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The…”
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Correction: Pokotylo, I., et al. Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1. Int. J. Mol. Sci. 2020, 21, 4678
Published in International journal of molecular sciences (09-10-2020)“…The authors wish to make the following correction to their published paper [...]…”
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Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility
Published in RNA biology (03-03-2016)“…The eukaryotic release factor 3 (eRF3) has been involved in the control of mRNA degradation through its association with the cytoplasmic Poly(A) Binding…”
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Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope
Published in Journal of immunology research (01-01-2019)“…The design of immunogens susceptible to elicit potent and broadly neutralizing antibodies against the human immunodeficiency virus type 1 (HIV-1) remains a…”
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New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain
Published in PLoS genetics (01-10-2012)“…Chromodomains are found in many regulators of chromatin structure, and most of them recognize methylated lysines on histones. Here, we investigate the role of…”
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HbS promotes TLR4-mediated monocyte activation and proinflammatory cytokine production in sickle cell disease
Published in Blood (03-11-2022)“…•Hemoglobin S, unlike hemoglobin A or heme, is responsible for TLR4-mediated monocyte activation.•Interaction between hemoglobin S and the TLR4/MD-2 complex…”
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The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase–LRP4 receptor complex by agrin at the neuromuscular junction
Published in The Journal of biological chemistry (01-08-2023)“…Collagen Q (ColQ) is a nonfibrillar collagen that plays a crucial role at the vertebrate neuromuscular junction (NMJ) by anchoring acetylcholinesterase to the…”
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Structural and Functional Characterization of a Human Potassium Channel, Kir2.1
Published in The FASEB journal (01-05-2021)“…Inwardly rectifying potassium (Kir) channels are ubiquitously present in prokaryotic and eukaryotic cells. Kir channels selectively control the permeation of…”
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The CH1[alpha] domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals
Published in PLoS pathogens (14-12-2020)“…The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating…”
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Chlordecone-induced hepatotoxicity and fibrosis are mediated by the proteasomal degradation of septins
Published in Journal of hazardous materials (05-09-2024)“…Chlordecone (CLD) is a pesticide persisting in soils and contaminating food webs. CLD is sequestered in the liver and poorly metabolized into chlordecol…”
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Structural and functional characterization of a human potassium channel, Kir2.1
Published in Biophysical journal (11-02-2022)Get full text
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Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen‐Tawil syndrome
Published in The FASEB journal (15-11-2024)“…Inwardly rectifying potassium (Kir) channels play a pivotal role in physiology by establishing, maintaining, and regulating the resting membrane potential of…”
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FAK dimerization controls its kinase-dependent functions at focal adhesions
Published in The EMBO journal (18-02-2014)“…Focal adhesion kinase (FAK) controls adhesion‐dependent cell motility, survival, and proliferation. FAK has kinase‐dependent and kinase‐independent functions,…”
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Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings: A comparative study
Published in Acta biomaterialia (01-06-2017)“…[Display omitted] Design of new osteoinductive biomaterials to reproduce an optimized physiological environment capable of recruiting stem cells and…”
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Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD
Published in Human molecular genetics (01-02-2016)“…POU1F1, a pituitary-specific POU-homeo domain transcription factor, plays an essential role in the specification of the somatotroph, lactotroph and thyrotroph…”
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