Search Results - "Taha Ali"

Editorial: The microbiome and gastric mucosal protection in aspirin users by Taha, Ali S.

“…LINKED CONTENT This article is linked to Løn et al papers. To view these articles, visit https://doi.org/10.1111/apt.17817 and https://doi.org/10.1111/apt.17826…”
Get full text

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety by Altıntop, Mehlika Dilek, Ciftci, Halil Ibrahim, Radwan, Mohamed O, Sever, Belgin, Kaplancıklı, Zafer Asım, Ali, Taha F S, Koga, Ryoko, Fujita, Mikako, Otsuka, Masami, Özdemir, Ahmet

“…In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple…”
Get full text

Editorial: blood transfusion for lower gastrointestinal bleeding by Taha, Ali S.

“…Linked ContentThis article is linked to Kherad et al and Kherad and Jairath papers. To view these articles, visit https://doi.org/10.1111/apt.15158 and…”
Get full text

The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities by Ciftci, Halil Ibrahim, Ozturk, Safiye Emirdag, Ali, Taha F. S., Radwan, Mohamed O., Tateishi, Hiroshi, Koga, Ryoko, Ocak, Zeynep, Can, Mustafa, Otsuka, Masami, Fujita, Mikako

“…The discovery of the chimeric tyrosine kinase breakpoint cluster region kinase-Abelson kinase (BCR-ABL)-targeted drug imatinib conceptually changed the…”
Get full text

Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors by Abdelbaset, Mahmoud S., Abdel-Aziz, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Abbas Bukhari, Syed Nasir, Ali, Taha F.S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
Get full text

An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models by Toma, Tsugumasa, Miyakawa, Nobukazu, Arakaki, Yuiichi, Watanabe, Takuro, Nakahara, Ryosei, Ali, Taha F. S., Biswas, Tanima, Todaka, Mikio, Kondo, Tatsuya, Fujita, Mikako, Otsuka, Masami, Araki, Eiichi, Tateishi, Hiroshi

“…Aims/hypothesis Appropriate management of blood glucose levels and the prevention of complications are important in the treatment of diabetes. We have…”
Get full text

In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents by Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Roshdy, Eslam, Mohamed, Dina E. M., Ali, Taha F. S., Gabr, Gamal A., Jaragh-Alhadad, Laila A., Mekhemer, Gamal A. H., Shawky, Ahmed M., Sidhom, Peter A., Abdelrahman, Alaa H. M.

“…Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD + -dependent and organize several biological…”
Get full text

Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020 by Roshdy, Eslam, Mustafa, Muhamad, Shaltout, Abd El-Rahman, Radwan, Mohamed O., Ibrahim, Mahmoud A.A., Soliman, Mahmoud E., Fujita, Mikako, Otsuka, Masami, Ali, Taha F.S.

“…Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various biological processes and is deemed as a novel biomarker for different cancers…”
Get full text

The protective role of two oxindole derivatives is mediated by modulating NLRP3/caspase-1 and PI3K/AKT pathways in a preclinical animal model of hepatic ischemia reperfusion injury by Eldafashi, Nardeen, Waaz, Shaimaa, Ali, Taha F.S., Zaki, Marco Y.W., Nazmy, Maiiada Hassan, Fathy, Moustafa

“…Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver transplantation, hypovolemic shock and trauma. In this study, we…”
Get full text

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity by I Ciftci, Halil, O Radwan, Mohamed, E Ozturk, Safiye, Ulusoy, N Gokce, Sozer, Ece, E Ellakwa, Doha, Ocak, Zeynep, Can, Mustafa, F S Ali, Taha, I Abd-Alla, Howaida, Yayli, Nurettin, Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako

“…Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance…”
Get full text

Combination of an Oxindole Derivative with (-)-β-Elemene Alters Cell Death Pathways in FLT3/ITD + Acute Myeloid Leukemia Cells by Alanazi, Jowaher, Bender, Onur, Dogan, Rumeysa, Malik, Jonaid Ahmad, Atalay, Arzu, Ali, Taha F S, Beshr, Eman A M, Shawky, Ahmed M, Aly, Omar M, Alqahtani, Yasir Nasser H, Anwar, Sirajudheen

“…Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options…”
Get full text

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

“…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
Get full text

Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac by Ali, Taha F. S., Moharram, Hossam Mohamed, Fathalla, Zeinab, Abd al-Qadir, Hamdi, Pierscionek, Barbara K.

“…With advances in refractive surgery and demand for cataract removal and lens replacement, the ocular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has…”
Get full text

Injectable magnesium-doped brushite cement for controlled drug release application by Saleh, Ali Taha, Ling, Lee Siew, Hussain, Rafaqat

“…Dicalcium phosphate dihydrate (CaHPO₄·2H₂O), also known as brushite, is one of the important bioceramics for bone regeneration. However, fast setting of the…”
Get full text

In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors by Sever, Belgin, Altıntop, Mehlika Dilek, Özdemir, Ahmet, Akalın Çiftçi, Gülşen, Ellakwa, Doha E, Tateishi, Hiroshi, Radwan, Mohamed O, Ibrahim, Mahmoud A A, Otsuka, Masami, Fujita, Mikako, Ciftci, Halil I, Ali, Taha F S

“…Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1…”
Get full text

Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial by Taha, Ali S, Dr, McCloskey, Caroline, BSc, Prasad, Rakesh, MRCP, Bezlyak, Vladimir, PhD

“…Summary Background There are few therapeutic options for the prevention of gastrointestinal mucosal damage caused by low-dose aspirin. We therefore…”
Get full text

Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition by Radwan, Mohamed O., Ciftci, Halil I., Ali, Taha F.S., Koga, Ryoko, Tateishi, Hiroshi, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Fujita, Mikako, Otsuka, Masami

“…[Display omitted] Sirtuin proteins are a highly conserved class of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases. The pleiotropic human…”
Get full text

Comparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo by Zaky, Mohamed S., Atallah, Rabie B., El Abasy, Nada Taha, Ali, Elsaie, Mohamed L.

“…Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the…”
Get full text

New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities by Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.A., Beshr, Eman A.M., Ali, Taha F.S.

“…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested…”
Get full text

Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug by Aly, Usama Farghaly, Sarhan, Hatem Abdel-Monsef, Ali, Taha F S, Sharkawy, Hosny Abd El-Bakey

“…The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan…”
Get full text