Search Results - "Taha, Mutasem O"

Degradability of chitosan micro/nanoparticles for pulmonary drug delivery by Islam, Nazrul, Dmour, Isra, Taha, Mutasem O

“…Chitosan, a natural carbohydrate polymer, has long been investigated for drug delivery and medical applications due to its biodegradability, biocompatibility…”
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Stable Chitosan-Based Nanoparticles Using Polyphosphoric Acid or Hexametaphosphate for Tandem Ionotropic/Covalent Crosslinking and Subsequent Investigation as Novel Vehicles for Drug Delivery by Saeed, Ramzi Mukred, Dmour, Isra, Taha, Mutasem O

“…Chitosan nanoparticles (NPs) are widely studied as vehicles for drug, protein, and gene delivery. However, lack of sufficient stability, particularly under…”
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Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 by Hatmal, Ma'mon M, Alshaer, Walhan, Al-Hatamleh, Mohammad A I, Hatmal, Malik, Smadi, Othman, Taha, Mutasem O, Oweida, Ayman J, Boer, Jennifer C, Mohamud, Rohimah, Plebanski, Magdalena

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged in China and caused a disease called coronavirus disease 2019 (COVID-19)…”
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Structure-Based Discovery and Bioactivity Evaluation of Novel Aurora-A Kinase Inhibitors as Anticancer Agents via Docking-Based Comparative Intermolecular Contacts Analysis (dbCICA) by Hijjawi, Majd S, Abutayeh, Reem Fawaz, Taha, Mutasem O

“…Aurora-A kinase plays a central role in mitosis, where aberrant activation contributes to cancer by promoting cell cycle progression, genomic instability,…”
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Design and Synthesis of New JAK1 Inhibitors based on Sulfonamide- Triazine Conjugates by Daoud, Safa, Taha, Mutasem O

“…Design of sulfonamide-triazine derivatives as JAK1 inhibitors. JAK1 is a kinase involved in different autoimmune diseases. JAK1 inhibitors have shown promising…”
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Elaboration of Novel TTK1 Inhibitory Leads via QSAR-Guided Selection of Crystallographic Pharmacophores Followed By In Vitro Assay by Al-Sha'er, Mahmoud A, Taha, Mutasem O

“…Tyrosine threonine kinase (TTK1) is a key regulator of chromosome segregation. Recently, TTK targeting came into focus for the enhancement of possible…”
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Reported Adverse Effects and Attitudes among Arab Populations Following COVID-19 Vaccination: A Large-Scale Multinational Study Implementing Machine Learning Tools in Predicting Post-Vaccination Adverse Effects Based on Predisposing Factors by Hatmal, Ma'mon M, Al-Hatamleh, Mohammad A I, Olaimat, Amin N, Mohamud, Rohimah, Fawaz, Mirna, Kateeb, Elham T, Alkhairy, Omar K, Tayyem, Reema, Lounis, Mohamed, Al-Raeei, Marwan, Dana, Rasheed K, Al-Ameer, Hamzeh J, Taha, Mutasem O, Bindayna, Khalid M

“…Background: The unprecedented global spread of coronavirus disease 2019 (COVID-19) has imposed huge challenges on the healthcare facilities, and impacted every…”
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Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling by Mera, Wafa A, Alzihlif, Malek, Taha, Mutasem O, Khanfar, Mohammad A

“…Bruton's Tyrosine Kinase (BTK) is a one of the Tec tyrosine kinase family. It has an essential role in B-cell development and function. Activation of BTK has…”
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Antiproliferative activity of the isoindigo 5′-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase by Saleh, Ayman M, El-Abadelah, Mustafa M, Aziz, Mohammad Azhar, Taha, Mutasem O, Nasr, Amre, Rizvi, Syed A.A

“…Highlights • 5'-Br is a novel isoindigo showing strong, selective antiproliferative activity against various hematological and solid tumor cell lines. • The…”
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Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors by Shahin, Rand, AlQtaishat, Saja, Taha, Mutasem O.

“…Rho Kinase (ROCKII) has been recently implicated in several cardiovascular diseases prompting several attempts to discover and optimize new ROCKII inhibitors…”
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Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease by Alsalahat, Izzeddin, Al-Majdoub, Zubida M., Taha, Mutasem O., Barber, Jill, Aojula, Harmesh, Hodson, Nigel, Freeman, Sally

“…The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic…”
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New leads for DPP IV inhibition: structure-based pharmacophore mapping and virtual screening study by Almasri, Ihab M., Taha, Mutasem O., Mohammad, Mohammad K.

“…Dipeptidyl peptidase IV (DPP IV) is an attractive target for the development of new antidiabetic drugs. DPP IV inhibitors improve glycemic control by…”
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Discovery of DPP IV Inhibitors by Pharmacophore Modeling and QSAR Analysis followed by in silico Screening by Al‐masri, Ihab M., Mohammad, Mohammad K., Taha, Mutasem O.

“…Dipeptidyl peptidase IV (DPP IV) deactivates the natural hypoglycemic incretin hormones. Inhibition of this enzyme should restore glucose homeostasis in…”
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The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60 by Saleh, Ayman M., Aljada, Ahmad, El-Abadelah, Mustafa M., Taha, Mutasem O., Sabri, Salim S., Zahra, Jalal A., Aziz, Mohammad Azhar

“…Background/Aims: The antileukemic potential of isoindigos make them desired candidates for understanding their mechanism of action. We have recently…”
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Novel nanoparticles based on chitosan-dicarboxylate conjugates via tandem ionotropic/covalent crosslinking with tripolyphosphate and subsequent evaluation as drug delivery vehicles by Dmour, Isra, Taha, Mutasem O.

“…[Display omitted] Chitosan-based nanoparticles prepared by ionotropic gelation are prone to stability issues. The aim of this work is to chemically modify…”
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Synthesis and Antitumor Activities of Some New N1-(Flavon-6-yl)amidrazone Derivatives by Habashneh, Almeqdad Y., El-Abadelah, Mustafa M., Zihlif, Malek A., Imraish, Amer, Taha, Mutasem O.

“…A new series of N1‐(flavon‐6‐yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6‐aminoflavone with the appropriate sec‐cyclic…”
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Pharmacophore modeling of JAK1: A target infested with activity-cliffs by Daoud, Safa, Taha, Mutasem O.

“…Janus kinase 1 (JAK1) is protein kinase involved in autoimmune diseases (AIDs). JAK1 inhibitors have shown promising results in treating AIDs. JAK1 inhibitors…”
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Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties by Saleh, Suhair, Taha, Mutasem O., Haddadin, Randa N., Marzooqa, Duá, Hodali, Hamdallah

“…Zinc- and silver-doped mullite ceramic discs were prepared and tested as potentially resistant materials against bacterial adhesion and biofilm formation…”
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Discovery of novel Flt3 inhibitory chemotypes through extensive ligand-based and new structure-based pharmacophore modelling methods by Abutayeh, Reem Fawaz, Taha, Mutasem O.

“…Flt3 is an oncogenic kinase involved in different types of leukemia. It is most prominently associated with acute myeloid leukemia (AML). Flt3-specific…”
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Exploring the influence of culture conditions on kefir's anticancer properties by Hatmal, Ma'mon M, Nuirat, Abeer, Zihlif, Malek A, Taha, Mutasem O

“…Cancer is a major health problem in many parts of the world. Conventional anticancer treatments are painful, expensive, and unsafe. Therefore, demand is…”
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