Search Results - "Taft, David"

Spatial clustering and common regulatory elements correlate with coordinated gene expression by Zhang, Jingyu, Chen, Hengyu, Li, Ruoyan, Taft, David A, Yao, Guang, Bai, Fan, Xing, Jianhua

“…Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a…”
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Application of Physiologically Based Pharmacokinetic‐Pharmacodynamic Modeling in Preterm Neonates to Guide Gentamicin Dosing Decisions and Predict Antibacterial Effect by Neeli, Harshith, Hanna, Nazeeh, Abduljalil, Khaled, Cusumano, Jaclyn, Taft, David R.

“…Clinical studies in preterm neonates are rarely performed due to ethical concerns and difficulties associated with trials and recruitment. Consequently, dose…”
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Learn to segment single cells with deep distance estimator and deep cell detector by Wang, Weikang, Taft, David A., Chen, Yi-Jiun, Zhang, Jingyu, Wallace, Callen T., Xu, Min, Watkins, Simon C., Xing, Jianhua

“…Single cell segmentation is a critical and challenging step in cell imaging analysis. Traditional processing methods require time and labor to manually…”
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Application of physiologically based pharmacokinetic modeling to predict drug disposition in pregnant populations by Jogiraju, Vamshi Krishna, Avvari, Suvarchala, Gollen, Rakesh, Taft, David R.

“…Pregnancy is associated with numerous physiological changes that influence absorption, distribution, metabolism and excretion. Moreover, the magnitude of these…”
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Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption by Jogiraju, Vamshi Krishna, Heimbach, Tycho, Toderika, Yuliana, Taft, David R.

“…Tizanidine is an alpha2-adrenergic agonist, used to treat spasticity associated with multiple sclerosis and spinal injury. Tizanidine is primarily metabolized…”
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Vstm3 is a member of the CD28 family and an important modulator of T‐cell function by Levin, Steven D., Taft, David W., Brandt, Cameron S., Bucher, Christoph, Howard, Edward D., Chadwick, Eric M., Johnston, Janet, Hammond, Angela, Bontadelli, Kristen, Ardourel, Daniel, Hebb, LuAnn, Wolf, Anitra, Bukowski, Thomas R., Rixon, Mark W., Kuijper, Joseph L., Ostrander, Craig D., West, James W., Bilsborough, Janine, Fox, Brian, Gao, Zeren, Xu, Wenfeng, Ramsdell, Fred, Blazar, Bruce R., Lewis, Katherine E.

“…Members of the CD28 family play important roles in regulating T‐cell functions and share a common gene structure profile. We have identified VSTM3 as a protein…”
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Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibits Improved Pharmacokinetic Profile in Rats Compared to the Micronized Form: Benefits of Thin Film Freezing by Moon, Chaeho, Sahakijpijarn, Sawittree, Maier, Esther Y., Taft, David R., Jara, Miguel O., Praphawatvet, Tuangrat, Manandhar, Rachana, Shetty, Nivedita, Lubach, Joseph, Narang, Ajit, Nagapudi, Karthik, Williams, Robert O.

“…Asthma is a common chronic disease affecting the airways in the lungs. The receptors of allergic cytokines, including interleukin (IL)-4, IL-5, and IL-13,…”
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Correction to “Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibits Improved Pharmacokinetic Profile in Rats Compared to the Micronized Form: Benefits of Thin Film Freezing” by Moon, Chaeho, Sahakijpijarn, Sawittree, Maier, Esther Y., Taft, David R., Jara, Miguel O., Praphawatvet, Tuangrat, Manandhar, Rachana, Shetty, Nivedita, Lubach, Joseph, Narang, Ajit, Nagapudi, Karthik, Williams, Robert O.

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PBPK Modeling of Azithromycin Systemic Exposure in a Roux-en-Y Gastric Bypass Surgery Patient Population by Avvari, Suvarchala Kiranmai, Cusumano, Jaclyn A, Jogiraju, Vamshi Krishna, Manchandani, Pooja, Taft, David R

“…In this investigation, PBPK modeling using the Simcyp® Simulator was performed to evaluate whether Roux-en-Y gastric bypass (RYGB) surgery impacts the oral…”
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Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole by Shah, Harsh, Shah, Kushal, Gajera, Bhavin, Dave, Rutesh H, Taft, David R

“…Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole…”
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Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F by Kuestner, Rolf E, Taft, David W, Haran, Aaron, Brandt, Cameron S, Brender, Ty, Lum, Karen, Harder, Brandon, Okada, Shannon, Ostrander, Craig D, Kreindler, James L, Aujla, Shean J, Reardon, Brian, Moore, Margaret, Shea, Pamela, Schreckhise, Randall, Bukowski, Thomas R, Presnell, Scott, Guerra-Lewis, Patricia, Parrish-Novak, Julia, Ellsworth, Jeff L, Jaspers, Stephen, Lewis, Katherine E, Appleby, Mark, Kolls, Jay K, Rixon, Mark, West, James W, Gao, Zeren, Levin, Steven D

“…The proinflammatory cytokines IL-17A and IL-17F have a high degree of sequence similarity and share many biological properties. Both have been implicated as…”
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Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats by Mudunuru, Jennypher, Ren, Chen, Taft, David R., Maniar, Manoj

“…Background and Objectives ON 123300, a small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being developed as a novel drug…”
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Evaluating the Potential for Delivery of Irinotecan via the Buccal Route: Physicochemical Characterization and In Vitro Permeation Assessment Across Porcine Buccal Mucosa by Shah, Vidhi, Bellantone, Robert A., Taft, David R.

“…Irinotecan (CPT-11) is used to treat advanced colorectal cancer as an intravenous therapy. Depending on pH, CPT-11 exists in either a lactone (active) or…”
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Real-World Experience With Higher-Than-Recommended Doses of Lamivudine in Patients With Varying Degrees of Renal Impairment by Fischetti, Briann, Shah, Kushal, Taft, David R, Berkowitz, Leonard, Bakshi, Anjali, Cha, Agnes

“…Although nucleoside reverse transcriptase inhibitors have been associated with lactic acidosis, lamivudine (3TC) has not been reported to have an increased…”
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Radioprotective Effects of ON 01210.Na upon Oral Administration by Suman, Shubhankar, Datta, Kamal, Doiron, Kathryn, Ren, Chen, Kumar, Ramesh, Taft, David R, Fornace, Jr, Albert J, Maniar, Manoj

“…ON 01210.Na (Ex-RAD), a chlorobenzylsulfone derivative was investigated for its pharmacologic and radioprotective properties when administered via oral and…”
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Determination of intestinal permeability of rigosertib (ON 01910.Na, Estybon): correlation with systemic exposure by White, Michael P., Babayeva, Mariana, Taft, David R., Maniar, Manoj

“…Objectives Rigosertib (ON 01910.Na, Estybon) is a novel, anticancer agent undergoing phase 3 clinical trials for a lead indication against myelodysplastic…”
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Rapid, modular, and cost-effective generation of donor DNA constructs for CRISPR-based gene knock-in by Chen, Yi-Jiun, Cheng, Ya-Yun, Wang, Weikang, Tian, Xiao-Jun, Lefever, Daniel E, Taft, David A, Zhang, Jingyu, Xing, Jianhua

“…Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing techniques find applications in many fields, such as molecular…”
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Disposition of ON 01210.Na (Ex-RAD(R)), a novel radioprotectant, in the isolated perfused rat liver: probing metabolic inhibition to increase systemic exposure by Tamhane, Mitalee, Maniar, Manoj, Ren, Chen, Benzeroual, Kenza E, Taft, David R

“…ON 01210.Na (Ex-RAD) is a novel benzyl styryl sulfone analog, developed as a radioprotectant by Onconova Therapeutics Inc. The objectives of this research were…”
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Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent by Chun, Amy W., Cosenza, Stephen C., Taft, David R., Maniar, Manoj

“…Purpose ON 01910.Na is a novel targeted anti-cancer agent under clinical investigation in Phase I and II trials. The purpose of this research was to evaluate…”
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Renal excretion of emtricitabine I: effects of organic anion, organic cation, and nucleoside transport inhibitors on emtricitabine excretion by Nakatani-Freshwater, Tomoko, Taft, David R

“…The excretion of emtricitabine (FTC) was characterized using isolated perfused rat kidney (IPK) model. Studies were performed to assess the dose-linearity of…”
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