Search Results - "Taft, Benjamin R"

Manipulating Micellar Environments for Enhancing Transition Metal-Catalyzed Cross-Couplings in Water at Room Temperature by Lipshutz, Bruce H, Ghorai, Subir, Leong, Wendy Wen Yi, Taft, Benjamin R, Krogstad, Daniel V

“…The remarkable effects of added salts on the properties of aqueous micelles derived from the amphiphile PTS are described. Most notably, Heck reactions run in…”
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Asymmetric Conjugate Reductions of Coumarins. A New Route to Tolterodine and Related Coumarin Derivatives by Gallagher, Brian D, Taft, Benjamin R, Lipshutz, Bruce H

“…The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichiometric DEMS (diethoxymethylsilane) in toluene at room temperature…”
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Heterogeneous Copper-in-Charcoal-Catalyzed Click Chemistry by Lipshutz, Bruce H., Taft, Benjamin R.

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Copper-in-Charcoal (Cu/C) Promoted Diaryl Ether Formation by Lipshutz, Bruce H, Unger, John B, Taft, Benjamin R

“…Copper impregnated into charcoal efficiently catalyzes cross-couplings between aryl bromides and phenols. The etherifications were conveniently promoted by…”
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Copper + Nickel-in-Charcoal (Cu−Ni/C): A Bimetallic, Heterogeneous Catalyst for Cross-Couplings by Lipshutz, Bruce H, Nihan, Danielle M, Vinogradova, Ekaterina, Taft, Benjamin R, Bošković, Žarko V

“…A new heterogeneous catalyst composed of copper and nickel oxide particles supported within charcoal has been developed. It catalyzes cross-couplings that…”
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Synthesis and Characterization of Isomeric Vinyl-1,2,3-triazole Materials by Azide−Alkyne Click Chemistry by Nulwala, Hunaid, Takizawa, Kenichi, Odukale, Anika, Khan, Anzar, Thibault, Raymond J, Taft, Benjamin R, Lipshutz, Bruce H, Hawker, Craig J

“…The synthesis of isomeric, functionalized 4-vinyl-1,2,3-triazole and 5-vinyl-1,2,3-triazole monomers is demonstrated using heterogeneous copper…”
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Microwave-Assisted Heterogeneous Cross-Coupling Reactions Catalyzed by Nickel-in-Charcoal (Ni/C) by Lipshutz, Bruce H., Frieman, Bryan A., Lee, Ching-Tien, Lower, Asher, Nihan, Danielle M., Taft, Benjamin R.

“…A study involving the relatively rare combination of heterogeneous catalysis conducted under microwave conditions is presented. Carbon–carbon bond formation,…”
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Heck Couplings at Room Temperature in Nanometer Aqueous Micelles by Lipshutz, Bruce H, Taft, Benjamin R

“…A nonionic amphiphile such as Triton X-100 or the vitamin E-based PTS, both of which form nanomicelles in water, promotes Heck cross-couplings of…”
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Catalytic Asymmetric Synthesis of the Pentacyclic Core of (+)-Citrinadin A by Trost, Barry M, Taft, Benjamin R, Tracy, Jacob S, Stivala, Craig E

“…The synthesis of the pentacylic core of (+)-citrinadin A is described. Our strategy harnesses the power of palladium-catalyzed trimethylenemethane chemistry…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria by Taft, Benjamin R, Yokokawa, Fumiaki, Kirrane, Tom, Mata, Anne-Catherine, Huang, Richard, Blaquiere, Nicole, Waldron, Grace, Zou, Bin, Simon, Oliver, Vankadara, Subramanyam, Chan, Wai Ling, Ding, Mei, Sim, Sandra, Straimer, Judith, Guiguemde, Armand, Lakshminarayana, Suresh B, Jain, Jay Prakash, Bodenreider, Christophe, Thompson, Christopher, Lanshoeft, Christian, Shu, Wei, Fang, Eric, Qumber, Jafri, Chan, Katherine, Pei, Luying, Chen, Yen-Liang, Schulz, Hanna, Lim, Jessie, Abas, Siti Nurdiana, Ang, Xiaoman, Liu, Yugang, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Gamo, Francisco Javier, Crespo-Fernandez, Benigno, Rosenthal, Philip J, Cooper, Roland A, Tumwebaze, Patrick, Aguiar, Anna Caroline Campos, Campo, Brice, Campbell, Simon, Wagner, Jürgen, Diagana, Thierry T, Sarko, Christopher

“…A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium…”
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A New Strategy for the Synthesis of Chiral β-Alkynyl Esters via Sequential Palladium and Copper Catalysis by Trost, Barry M, Taft, Benjamin R, Masters, James T, Lumb, Jean-Philip

“…A new strategy for the synthesis of chiral β-alkynyl esters which relies on sequential Pd and Cu catalysis is reported. Terminal alkynes bearing aryl, alkyl,…”
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Asymmetric synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives via sequential palladium and copper catalysis by Trost, Barry M, Masters, James T, Taft, Benjamin R, Lumb, Jean-Philip

“…We present a full account detailing the development of a sequential catalysis strategy for the synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Rhodium-Catalyzed Asymmetric 1,4-Additions, in Water at Room Temperature, with In-Flask Catalyst Recycling by Lipshutz, Bruce H., Isley, Nicholas A., Moser, Ralph, Ghorai, Subir, Leuser, Helena, Taft, Benjamin R.

“…Using the newly introduced designer surfactant polyethylene glycol ubiquinol sebacate (PQS), as the platform for micellar catalysis, non‐racemic BINAP has been…”
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Asymmetric 1,4-Hydrosilylations of α,β-Unsaturated Esters by Lipshutz, Bruce H, Servesko, Jeff M, Taft, Benjamin R

“…Complexing catalytic amounts of CuH with a nonracemic JOSIPHOS or SEGPHOS ligand, together with stoichiometric PMHS, leads to exceedingly efficient and highly…”
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Chiral Silanes via Asymmetric Hydrosilylation with Catalytic CuH by Lipshutz, Bruce H, Tanaka, Naoki, Taft, Benjamin R, Lee, Ching-Tien

“…CuH-catalyzed asymmetric conjugate reduction of β-silyl-α,β-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ…”
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Catalysis in the Service of Green Chemistry: Nobel Prize-Winning Palladium-Catalysed Cross-Couplings, Run in Water at Room Temperature: Heck, Suzuki-Miyaura and Negishi reactions carried out in the absence of organic solvents, enabled by micellar catalysis by Lipshutz, Bruce H, Taft, Benjamin R, Abela, Alexander R, Ghorai, Subir, Krasovskiy, Arkady, Duplais, Christophe

“…Palladium-catalysed cross-couplings, in particular Heck, Suzuki-Miyaura and Negishi reactions developed over three decades ago, are routinely carried out in…”
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New technologies in catalysis using base metals by Lipshutz, Bruce H., Butler, Tom, Frieman, Bryan A., Kogan, Vladimir, Lee, Ching-Tien, Lower, Asher, Nihan, Danielle M., Taft, Benjamin R., Tomaso, Anthony E.

“…Formation of C-C, C-N, and C-H bonds using three heterogeneous catalysts in the form of nickel-in-charcoal (Ni/C), nickel-on-graphite (Ni/C ), and…”
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Research, Teaching, and Professional Development at a Comprehensive University by Ball, David B, Wood, Mike, Lindsley, Craig, Mollard, Paul, Buzard, D. J, Vivian, Randy, Mahoney, Max, Taft, Benjamin R

“…The interrelationships between teaching, research, and professional development at comprehensive undergraduate institutions continue to be a focus of the…”
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