Search Results - "Taetzsch, Thomas"

Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity by Levesque, Shannon, Taetzsch, Thomas, Lull, Melinda E., Kodavanti, Urmila, Stadler, Krisztian, Wagner, Alison, Johnson, Jo Anne, Duke, Laura, Kodavanti, Prasada, Surace, Michael J., Block, Michelle L.

“…Background: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. Objectives: Here, we sought to…”
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Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice by Shapiro, Dillon, Massopust, Ryan, Taetzsch, Thomas, Valdez, Gregorio

“…miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard. We…”
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Specific labeling of synaptic schwann cells reveals unique cellular and molecular features by Castro, Ryan, Taetzsch, Thomas, Vaughan, Sydney K, Godbe, Kerilyn, Chappell, John, Settlage, Robert E, Valdez, Gregorio

“…Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development,…”
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KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice by Massopust, Ryan, Juros, Devin, Shapiro, Dillon, Lopes, Mikayla, Haldar, Saptarsi M., Taetzsch, Thomas, Valdez, Gregorio

“…Amyotrophic Lateral Sclerosis (ALS) is a currently incurable disease that causes progressive motor neuron loss, paralysis and death. Skeletal muscle pathology…”
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Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain by Taetzsch, Thomas, Benusa, Savannah, Levesque, Shannon, Mumaw, Christen L, Block, Michelle L

“…While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB…”
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Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging by Zeitz, Michael J., Calhoun, Patrick J., James, Carissa C., Taetzsch, Thomas, George, Kijana K., Robel, Stefanie, Valdez, Gregorio, Smyth, James W.

“…Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under…”
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NMJ maintenance and repair in aging by Taetzsch, Thomas, Valdez, Gregorio

“…•Impact of aging on NMJs.•Effects of exercise and a caloric restricted diet on aging NMJs.•Molecules that maintain and repair NMJs. As the final output of the…”
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Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS by Taetzsch, Thomas, Tenga, Milagros J, Valdez, Gregorio

“…The identity of muscle secreted factors critical for the development and maintenance of neuromuscular junctions (NMJs) remains largely unknown. Here, we show…”
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FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system by Taetzsch, Thomas, Brayman, Vanessa L., Valdez, Gregorio

“…Members of the fibroblast growth factor (FGF) family are involved in a variety of cellular processes. In the nervous system, they affect the differentiation…”
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The microRNA miR‐133b functions to slow Duchenne muscular dystrophy pathogenesis by Taetzsch, Thomas, Shapiro, Dillon, Eldosougi, Randa, Myers, Tracey, Settlage, Robert E., Valdez, Gregorio

“…Key points Impairment of muscle biogenesis contributes to the progression of Duchenne muscular dystrophy (DMD). As a muscle enriched microRNA that has been…”
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Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS by Taetzsch, Thomas, Tenga, Milagros J, Valdez, Gregorio

“…The identity of muscle secreted factors critical for the development and maintenance of neuromuscular junctions (NMJs) remains largely unknown. Here, we show…”
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Redox regulation of NF-κB p50 and M1 polarization in microglia by Taetzsch, Thomas, Levesque, Shannon, McGraw, Constance, Brookins, Savannah, Luqa, Rafy, Bonini, Marcelo G., Mason, Ronald P., Oh, Unsong, Block, Michelle L.

“…Redox‐signaling is implicated in deleterious microglial activation underlying CNS disease, but how ROS program aberrant microglial function is unknown. Here,…”
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Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair by Brayman, Vanessa L., Taetzsch, Thomas, Miko, MacKenzie, Dahal, Shreyaska, Risher, W. Christopher, Valdez, Gregorio

“…•Hevin and SPARC are expressed by mouse skeletal muscles and present at the neuromuscular junction (NMJ) during its formation.•Deletion of Hevin, but not…”
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The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions by Dalkin, William, Taetzsch, Thomas, Valdez, Gregorio

“…The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative to…”
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Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats by Hyer, Molly M, Dyer, Samya K, Kloster, Alix, Adrees, Anum, Taetzsch, Thomas, Feaster, Jonathan, Valdez, Gregorio, Neigh, Gretchen N

“…Sex differences are evident in the presentation of metabolic symptoms. A shift of sex hormones that signal the onset of puberty combined with a poor diet…”
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The role of MAC1 in diesel exhaust particle‐induced microglial activation and loss of dopaminergic neuron function by Levesque, Shannon, Taetzsch, Thomas, Lull, Melinda E., Johnson, Jo Anne, McGraw, Constance, Block, Michelle L.

“…Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles…”
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Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1 G93A mice by Shapiro, Dillon, Massopust, Ryan, Taetzsch, Thomas, Valdez, Gregorio

“…miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard. We…”
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Pesticides, Microglial NOX2, and Parkinson's Disease by Taetzsch, Thomas, Block, Michelle L.

“…ABSTRACT Accumulating evidence indicates that pesticide exposure is associated with an increased risk for developing Parkinson's disease (PD). Several…”
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Loss of NF-?B p50 function synergistically augments microglial priming in the middle-aged brain by Taetzsch, Thomas, Benusa, Savannah, Levesque, Shannon, Mumaw, Christen L, Block, Michelle L

“…Background While NF-?B p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role…”
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The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions by Dalkin, William, Taetzsch, Thomas, Valdez, Gregorio

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