Search Results - "Taesik, Gwag"

Thrombospondin1 antagonist peptide treatment attenuates obesity-associated chronic inflammation and metabolic disorders in a diet-induced obese mouse model by Zhou, Qi, Gwag, Taesik, Wang, Shuxia

“…Thrombospondin1 (TSP1) is a multifunctional matricellular protein. Previously, we demonstrated that TSP1 plays a pivotal role in obesity-related inflammation…”
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Anti‐CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non‐alcoholic steatohepatitis models by Gwag, Taesik, Ma, Eric, Zhou, Changcheng, Wang, Shuxia

“…Background & Aims With the epidemic burden of obesity and metabolic diseases, nonalcoholic fatty liver disease (NAFLD) including steatohepatitis (NASH) has…”
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Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis by Gwag, Taesik, Meng, Zhaojie, Sui, Yipeng, Helsley, Robert N., Park, Se-Hyung, Wang, Shuxia, Greenberg, Richard N., Zhou, Changcheng

“…[Display omitted] •Efavirenz is widely prescribed for patients with HIV.•Efavirenz increases the risk of dyslipidemia and hepatic steatosis in…”
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CD47 antisense oligonucleotide treatment attenuates obesity and its-associated metabolic dysfunction by Gwag, Taesik, Li, Dong, Ma, Eric, Guo, Zhenheng, Liang, Ying, Wang, Shuxia

“…Previous study from our lab has revealed a new role of CD47 in regulating adipose tissue function, energy homeostasis and the development of obesity and…”
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HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development in Low-Density Lipoprotein Receptor–Deficient Mice by Meng, Zhaojie, Hernandez, Rebecca, Liu, Jingwei, Gwag, Taesik, Lu, Weiwei, Hsiai, Tzung K, Kaul, Marcus, Zhou, Tong, Zhou, Changcheng

“…Purpose HIV infection is consistently associated with an increased risk of atherosclerotic cardiovascular disease, but the underlying mechanisms remain…”
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Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease by Gwag, Taesik, Reddy Mooli, Raja Gopal, Li, Dong, Lee, Sangderk, Lee, Eun Y., Wang, Shuxia

“…Thrombospondin 1 (TSP1) is a multifunctional matricellular protein. We previously showed that TSP1 has an important role in obesity-associated metabolic…”
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Platelet-derived thrombospondin 1 promotes immune cell liver infiltration and exacerbates diet-induced steatohepatitis by Gwag, Taesik, Lee, Sangderk, Li, Zhenyu, Newcomb, Alana, Otuagomah, Josephine, Weinman, Steven A., Liang, Ying, Zhou, Changcheng, Wang, Shuxia

“…Recent studies have implicated platelets, particularly α-granules, in the development of non-alcoholic steatohepatitis (NASH). However, the specific mechanisms…”
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The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling by Meng, Zhaojie, Gwag, Taesik, Sui, Yipeng, Park, Se-Hyung, Zhou, Xiangping, Zhou, Changcheng

“…Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in…”
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Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways by Gwag, Taesik, Park, Kyoungsook, Kim, Eunjung, Son, Chaeyeon, Park, Junsoo, Nikawa, Takeshi, Choi, Inho

“…•Triterpene celastrol (CEL) is known as a potent heat shock protein (HSP) inducer.•CEL treatment raised C2C12 cell size vs. control but abolished DEX-induced…”
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N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle by Ochi, Arisa, Abe, Tomoki, Nakao, Reiko, Yamamoto, Yoriko, Kitahata, Kanako, Takagi, Marina, Hirasaka, Katsuya, Ohno, Ayako, Teshima-Kondo, Shigetada, Taesik, Gwag, Choi, Inho, Kawamura, Tomoyuki, Nemoto, Hisao, Mukai, Rie, Terao, Junji, Nikawa, Takeshi

“…•The penta-peptide DGpYMP (Cblin) inhibited the muscle atrophy caused by glucocorticoids.•N-myristoylated Cblin prevented such muscle atrophy in vitro and in…”
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Overcoming muscle atrophy in a hibernating mammal despite prolonged disuse in dormancy: Proteomic and molecular assessment by Lee, Kisoo, Park, Joo Young, Yoo, Woojae, Gwag, Taesik, Lee, Ju-Woon, Byun, Myung-Woo, Choi, Inho

“…Prolonged disuse of skeletal muscle causes significant loss of myofibrillar contents, muscle tension, and locomotory capacity. However, hibernating mammals…”
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Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis by Li, Dong, Gwag, Taesik, Wang, Shuxia

“…Our previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications…”
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Absence of CD47 maintains brown fat thermogenic capacity and protects mice from aging-related obesity and metabolic disorder by Li, Dong, Gwag, Taesik, Wang, Shuxia

“…Brown and beige adipocytes burn energy to produce heat and could serve as a therapeutic target to counteract metabolic diseases including obesity and type 2…”
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Stress and Signaling Responses of Rat Skeletal Muscle to Brief Endurance Exercise During Hindlimb Unloading: a Catch-Up Process for Atrophied Muscle by Gwag, Taesik, Lee, Kisoo, Ju, Hyunwoo, Shin, Haksup, Lee, Ju-Woon, Choi, Inho

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Metabolomic, Lipidomic, Transcriptomic, and Metagenomic Analyses in Mice Exposed to PFOS and Fed Soluble and Insoluble Dietary Fibers by Deng, Pan, Durham, Jerika, Liu, Jinpeng, Zhang, Xiaofei, Wang, Chi, Li, Dong, Gwag, Taesik, Ma, Murong, Hennig, Bernhard

“…Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant that has become a significant concern around the world. Exposure to PFOS may alter gut…”
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Abstract 100: HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development in LDLR-deficient Mice by Meng, Zhaojie, Lu, Weiwei, Gwag, Taesik, Zhou, Changcheng

“…Abstract only Introduction: As the average lifespan of HIV-infected patients receiving anti-retroviral therapy lengthens, morbidity and mortality from…”
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Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice by Sui, Yipeng, Meng, Zhaojie, Chen, Jianzhong, Liu, Jingwei, Hernandez, Rebecca, Gonzales, Miko B, Gwag, Taesik, Morris, Andrew J, Zhou, Changcheng

“…Exposure to plastic-associated endocrine disrupting chemicals (EDCs) has been associated with an increased risk of cardiovascular disease (CVD) in humans…”
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Myeloid β-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice by Wang, Fang, Liu, Zun, Park, Se-Hyung, Gwag, Taesik, Lu, Weiwei, Ma, Murong, Sui, Yipeng, Zhou, Changcheng

“…OBJECTIVE—The Wnt/β-catenin signaling is an ancient and evolutionarily conserved pathway that regulates essential aspects of cell differentiation,…”
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Erratum to: Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis [J Hepatol (2019); 70 (5): 930–940] by Gwag, Taesik, Meng, Zhaojie, Sui, Yipeng, Helsley, Robert N., Park, Se-Hyung, Wang, Shuxia, Greenberg, Richard N., Zhou, Changcheng

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Abstract 632: Myeloid beta catenin Deficiency Exacerbates Atherosclerosis in Low-density Lipoprotein-receptor Deficient Mice by Wang, Fang, Liu, Zun, Park, Se-Hyung, Gwag, Taesik, Lu, Weiwei, Ma, Murong, Sui, Yipeng, Zhou, Changcheng

“…Abstract only Objective: The Wnt/β-catenin signaling is an ancient and evolutionarily conserved pathway that regulates essential aspects of cell…”
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