Search Results - "Taehun Song"

A Novel and Potent EZH1/2 Dual Inhibitor HM97594 for the Treatment of Hematological Malignancies by Jung, Seung Hyun, Hong, DongJin, Kim, SeoHee, Hwang, Jiyoung, Byun, Jooyun, Lee, Miyoung, Koo, Kyounghwa, Lee, Gunwoo, Song, TaeHun, Lim, SunYoung, Kim, Yu-Yon, Park, Hyunjin, Bak, Yesol, Ko, Myoungsil, Jung, Sunyoung, Han, Yuri, Ahn, YoungGil, Kim, YoungHoon, Suh, KweeHyun

“…In mammals, either enhancer of zeste homologue 2 (EZH2) or its homolog EZH1 functions as the catalytic subunit of polycomb repressive complex 2 (PRC2), and…”
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Synthesis and Evaluation of a 3,4‐dihydro‐2H‐benzoxazine Derivative as a Potent CDK9 Inhibitor for Anticancer Therapy by Song, Taehun, Lee, Moonsub, Bae, Inhwan, Byun, Joo‐Yun, Ahn, Young Gil, Kim, Young Hoon, Chun, Young‐Jin

“…Cyclin‐dependent kinase (CDK) 9 is a protein kinase that plays a major regulatory role in the process of transcription, thereby representing an attractive…”
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Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel by Liu, Donghai, Song, Andrew Taehun, Qi, Xiaoyan, van Vliet, Patrick Piet, Xiao, Jiening, Xiong, Feng, Andelfinger, Gregor, Nattel, Stanley

“…Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes…”
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Development of a new standard model of GIB using electromagnetic-structural coupled analysis by Chan Park, Taehun Song

“…To develop a new standard design of gas-insulated bus (GIB), an electromagnetic-structural finite element analysis has been conducted considering the…”
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Structural safety evaluation of the inner conductors in GIB (Gas Insulated Bus) using electromagnetic structural coupled analysis by Park, Chan, Taehun Song, Taekyung Kim

“…This paper presents an electromagnetic-structural finite element analysis considering the electromagnetic force generated in the GIB(Gas Insulated Bus) by a…”
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Belvarafenib penetrates the BBB and shows potent antitumor activity in a murine melanoma brain metastasis model by Kim, Yu-Yon, Park, Hyunjin, Song, Taehun, Choi, Kyungjin, Dolton, Michael, Mao, Jialin, Kim, Jisook, Ahn, Young Gil, Suh, Kwee Hyun, Kim, Young Hoon

“…Brain metastasis is a common complication in melanoma patients with BRAF and NRAS mutations and has a poor prognosis. Although BRAF inhibitors are clinically…”
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Abstract 1257: HM43239, a novel FLT3 inhibitor, has the potential to inhibit mutations resistant to FLT3 inhibitors by Bae, Inhwan, Choi, Jaeyul, Song, Jiyoung, Byun, Joo-Yun, Lee, Eunyoung, Song, Taehun, Kim, Yu-Yon, Bak, Yesol, Kim, Young Hoon, Ahn, Young Gil, Suh, Kwee Hyun

“…Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) mutations is associated with poor prognosis with a high risk of relapse after therapy and…”
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Abstract 3833: Antitumor activity of novel reversible LSD1 inhibitor in preclinical models of AML and SCLC by Bae, InHwan, Kim, WonJeoun, Kim, JiSook, Song, JiYoung, Nam, JungSoo, Lee, Moonsub, Byun, Jooyun, Kim, Hyeongki, Song, TaeHun, Hong, Seokhyun, Lee, KyuHang, Ahn, YoungGil, Kim, YoungHoon, Suh, Kwee Hyun

“…Introduction: Global changes in the epigenetic landscape are known as the hallmark in cancer and the histone demethylase Lysine-specific demethylase 1 (LSD1)…”
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Abstract 4780: A novel, potent and selective FGFR4 inhibitor, HM81422 in hepatocellular carcinoma with FGFR4-driven pathway activation by Lee, JaeHo, Kang, Hyunjeong, Koo, Kyounghwa, Ha, Youngeun, Lim, Sun Young, Byun, Joo-Yun, Yu, Hyunkyung, Song, Taehun, Lee, Moonsub, Jung, Seung Hyun, Kim, Taewoo, Bang, Hyojeong, Kim, Eunyoung, Kang, Jahoon, Lee, Ho Jeong, Kim, YoungHoon, Ahn, YoungGil, Suh, KweeHyun, Kim, Sun-Jin

“…Introduction: Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the second most frequent cause of cancer-related death, however, treatment…”
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Abstract 2606: Antitumor activity of the selective RAF inhibitor HM95573 in melanoma by Bae, InHwan, Ahn, YoungGil, GwangMo, Namgoong, Kim, SuHyeon, Song, JiYeon, Song, TaeHun, Lee, JaeHo, Lee, KyuHang, Lee, Young-Mi, Kim, YoungHoon, Suh, KweeHyun

“…The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of tumor cells. Activation of the MAPK pathway…”
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Abstract LB-256: Optimal clinical dose-finding strategies: Translational preclinical pharmacokineitcs, pharmacodynamics, and efficacy analysis of HM61713, an orally selective EGFR mutant inhibitor by Byun, Jooyun, Song, Taehun, Kim, Donghyun, Son, Junhyeng, Lee, Kwang-Ok, Lee, Jaeho, Kim, Yong Hoon, Lee, Young-Mi, Suh, Kwee Hyun

“…The first-generation of EGFR1 inhibitors (Gefitinib and Erlotinib) has significant clinical benefits in NSCLC caused by activating mutations, but the efficacy…”
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Investigation of arc and flow characteristics of self blast type circuit breakers by simulation by Taehun Song, Yeon Poong Kim, Jong Sung Kang, Byung Hwa Choi, Kwang-Cheol Ko

“…Self blast type circuit breakers generate pressure required to interrupt the breaking current, using arc plasma that is ignited between arcing contacts of the…”
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Abstract 1625: A novel SOS1 inhibitor, HM99462 demonstrates antitumor activity against KRAS-mutant cancers by Jung, Seung Hyun, Choi, Jaeyul, Park, Wongi, Byun, Jooyun, Lim, Semi, Lee, Youngjoo, Kim, Yu-Yon, Park, Hyunjin, Jeon, So-Ye, Song, Taehun, Choi, Kyungjin, Kong, Tae-yeon, Kim, Heecheol, Jang, Wook, Lee, EunYoung, Kim, Minhwa, Ahn, Young Gil, Kim, Young Hoon, Suh, Kwee Hyun

“…KRAS is a well-known oncogene with the highest mutation rate among various cancers. KRAS cycles between GDP-loaded ‘off’ and GTP-loaded ‘on’ states induce…”
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Plasma arc simulation of high voltage circuit breaker with a hybrid 2D/3D model by Park, Yongnam, Song, Taehun

“…A hybrid 2D-3D CFD (Computational Fluid Dynamics) model is developed for studying plasma arc behavior in high voltage circuit breaker. Usually the shape of…”
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Co-simulation for dynamic characteristics analysis of the ultra-high voltage circuit breaker by Ahn, Ilchul, Park, Yongnam, Song, Taehun

“…The Ultra-High Voltage (UHV) Circuit Breaker (CB) is a protective device that applies power to the power system through close - open operations and ensures the…”
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Investigation of arc and flow characteristics of self blast type circuit breakers by simulation by Taehun Song, Kwang-Cheol Ko, Yeon Poong Kim, Jong Sung Kang, Byung Hwa Choi

“…Summary form only given. Self blast type circuit breakers generate pressure required to interrupt the breaking current, using arc plasma that is ignited…”
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Characterization of Sgo1 Expression and Localization in Developing and Adult Mouse by Song, Andrew Taehun

“…SGO1 has been characterized in its function in correct cell division and its role in centrosome cohesion. However, its organ-specific maturation-related…”
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