Search Results - "Tadokoro, Yuko"

The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life by Tadokoro, Yuko, Hirao, Atsushi

“…Nutrients are converted by the body to smaller molecules, which are utilized for both anabolic and catabolic metabolic reactions. Cooperative regulation of…”
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Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma by Jing, Yongwei, Kobayashi, Masahiko, Vu, Ha Thi, Kasahara, Atsuko, Chen, Xi, Pham, Loc Thi, Kurayoshi, Kenta, Tadokoro, Yuko, Ueno, Masaya, Todo, Tomoki, Nakada, Mitsutoshi, Hirao, Atsushi

“…Lysosomes function as the digestive system of a cell and are involved in macromolecular recycling, vesicle trafficking, metabolic reprogramming, and progrowth…”
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Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner by Nomura, Naho, Ito, Chiaki, Ooshio, Takako, Tadokoro, Yuko, Kohno, Susumu, Ueno, Masaya, Kobayashi, Masahiko, Kasahara, Atsuko, Takase, Yusuke, Kurayoshi, Kenta, Si, Sha, Takahashi, Chiaki, Komatsu, Masaaki, Yanagawa, Toru, Hirao, Atsushi

“…Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic…”
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Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress by Tadokoro, Yuko, Hoshii, Takayuki, Yamazaki, Satoshi, Eto, Koji, Ema, Hideo, Kobayashi, Masahiko, Ueno, Masaya, Ohta, Kumiko, Arai, Yuriko, Hara, Eiji, Harada, Kenichi, Oshima, Masanobu, Oshima, Hiroko, Arai, Fumio, Yoshimura, Akihiko, Nakauchi, Hiromitsu, Hirao, Atsushi

“…Stem cell self-renewal is critical for tissue homeostasis, and its dysregulation can lead to organ failure or tumorigenesis. While obesity can induce varied…”
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RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia by Pham, Loc Thi, Peng, Hui, Ueno, Masaya, Kohno, Susumu, Kasada, Atuso, Hosomichi, Kazuyoshi, Sato, Takehiro, Kurayoshi, Kenta, Kobayashi, Masahiko, Tadokoro, Yuko, Kasahara, Atsuko, Shoulkamy, Mahmoud I., Xiao, Bo, Worley, Paul F., Takahashi, Chiaki, Tajima, Atsushi, Hirao, Atsushi

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Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells by Peng, Hui, Kasada, Atsuo, Ueno, Masaya, Hoshii, Takayuki, Tadokoro, Yuko, Nomura, Naho, Ito, Chiaki, Takase, Yusuke, Vu, Ha Thi, Kobayashi, Masahiko, Xiao, Bo, Worley, Paul F., Hirao, Atsushi

“…The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) senses a cell's energy status and environmental levels of nutrients and growth factors. In…”
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Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas by Vu, Ha Thi, Kobayashi, Masahiko, Hegazy, Ahmed M., Tadokoro, Yuko, Ueno, Masaya, Kasahara, Atsuko, Takase, Yusuke, Nomura, Naho, Peng, Hui, Ito, Chiaki, Ino, Yasushi, Todo, Tomoki, Nakada, Mitsutoshi, Hirao, Atsushi

“…Autophagy plays a critical role in tumorigenesis, but how autophagy contributes to cancer cells’ responses to chemotherapeutics remains controversial. To…”
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Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation by Kurayoshi, Kenta, Takase, Yusuke, Ueno, Masaya, Ohta, Kumiko, Fuse, Kyoko, Ikeda, Shuji, Watanabe, Takayoshi, Nishida, Yuki, Horike, Shin-ichi, Hosomichi, Kazuyoshi, Ishikawa, Yuichi, Tadokoro, Yuko, Kobayashi, Masahiko, Kasahara, Atsuko, Jing, Yongwei, Shoulkamy, Mahmoud I., Meguro-Horike, Makiko, Kojima, Kensuke, Kiyoi, Hitoshi, Sugiyama, Hiroshi, Nagase, Hiroki, Tajima, Atsushi, Hirao, Atsushi

“…Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more versatile…”
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Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells by Hoshii, Takayuki, Kasada, Atsuo, Hatakeyama, Tomoki, Ohtani, Masashi, Tadokoro, Yuko, Naka, Kazuhito, lkenoue, Tsuneo, ikawa, Tomokatsu, Kawamoto, Hiroshi, Fehling, Hans Joerg, Araki, Kimi, Yamamura, Ken-ichi, Matsuda, Satoshi, Hirao, Atsushi

“…mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and responding to environmental determinants. Recent studies have shown that…”
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Regulation of hematopoietic stem cell homeostasis by Spred1 by Tadokoro, Yuko, Hirao, Atsushi

“…Various types of stresses account for the dysregulation of the self-renewal activity of stem cells, resulting in the functional failure of tissues or…”
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Lnk Negatively Regulates Self-Renewal of Hematopoietic Stem Cells by Modifying Thrombopoietin-Mediated Signal Transduction by Seita, Jun, Ema, Hideo, Ooehara, Jun, Yamazaki, Satoshi, Tadokoro, Yuko, Yamasaki, Akiko, Eto, Koji, Takaki, Satoshi, Takatsu, Kiyoshi, Nakauchi, Hiromitsu

“…One of the central tasks of stem cell biology is to understand the molecular mechanisms that control self-renewal in stem cells. Several cytokines are…”
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Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis by Kato, Yuko, Iwama, Atsushi, Tadokoro, Yuko, Shimoda, Kazuya, Minoguchi, Mayu, Akira, Shizuo, Tanaka, Minoru, Miyajima, Atsushi, Kitamura, Toshio, Nakauchi, Hiromitsu

“…Although the concept of a leukemic stem cell system has recently been well accepted, its nature and the underlying molecular mechanisms remain obscure…”
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Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples by Ueno, Masaya, Tomita, Takuya, Arakawa, Hiroshi, Kakuta, Takahiro, Yamagishi, Tada-aki, Terakawa, Jumpei, Daikoku, Takiko, Horike, Shin-ichi, Si, Sha, Kurayoshi, Kenta, Ito, Chiaki, Kasahara, Atsuko, Tadokoro, Yuko, Kobayashi, Masahiko, Fukuwatari, Tsutomu, Tamai, Ikumi, Hirao, Atsushi, Ogoshi, Tomoki

“…Metabolic syndrome is associated with obesity, hypertension, and dyslipidemia, and increased cardiovascular risk. Therefore, quick and accurate measurements of…”
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Molecular pathology of tumor-initiating cells: Lessons from Philadelphia chromosome-positive leukemia by Naka, Kazuhito, Hoshii, Takayuki, Tadokoro, Yuko, Hirao, Atsushi

“…Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor‐initiating…”
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Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals by Yamada, Daisuke, Hoshii, Takayuki, Tanaka, Shingo, Hegazy, Ahmed M, Kobayashi, Masahiko, Tadokoro, Yuko, Ohta, Kumiko, Ueno, Masaya, Ali, Mohamed A E, Hirao, Atsushi

“…Glioblastomas frequently harbour genetic lesions that stimulate the activity of mammalian target of rapamycin complex 1 (mTORC1). Loss of heterozygosity of…”
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Dramatic Expansion of Germinal Stem Cells by Ectopically Expressed Human Glial Cell Line-Derived Neurotrophic Factor in Mouse Sertoli Cells by YOMOGIDA, Kentaro, YAGURA, Yo, TADOKORO, Yuko, NISHIMUNE, Yoshitake

“…Although the mammalian germinal stem cell (GSC) provides a good model to investigate the regulation of stem cells, the small number of these cells currently…”
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NKX2.2 Suppresses Self-Renewal of Glioma-Initiating Cells by MURAGUCHI, Teruyuki, TANAKA, Shingo, INO, Yasushi, TODO, Tomoki, KURATSU, Jun-Ichi, SAYA, Hideyuki, HAMADA, Jun-Ichiro, HIRAO, Atsushi, YAMADA, Daisuke, TAMASE, Akira, NAKADA, Mitsutoshi, NAKAMURA, Hideo, HOSHII, Takayuki, OOSHIO, Takako, TADOKORO, Yuko, NAKA, Kazuhito

“…Glioblastoma (GBM) is the most aggressive and destructive form of brain cancer. Animal models that can unravel the mechanisms underlying its progression are…”
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Novel Actin-Like Proteins T-ACTIN 1 and T-ACTIN 2 Are Differentially Expressed in the Cytoplasm and Nucleus of Mouse Haploid Germ Cells by Tanaka, Hiromitsu, Iguchi, Naoko, Egydio de Carvalho, Carlos, Tadokoro, Yuko, Yomogida, Kentaro, Nishimune, Yoshitake

“…We isolated cDNA clones for the novel actin-like proteins T-ACTIN 1 and T-ACTIN 2, which are expressed specifically in the mouse testis. These clones were from…”
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Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway by Tadokoro, Yuko, Yomogida, Kentaro, Ohta, Hiroshi, Tohda, Akira, Nishimune, Yoshitake

“…Stem cell regulatory mechanisms are difficult to study because self-renewal and production of differentiated progeny, which are both strictly controlled, occur…”
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De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells by Tadokoro, Yuko, Ema, Hideo, Okano, Masaki, Li, En, Nakauchi, Hiromitsu

“…DNA methylation is an epigenetic modification essential for development. The DNA methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in…”
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