Catabolism of membrane phosphatidylcholines during early stages of mitogenic initiation of phosphoinositide cycle in lymphocytes

Deacylation of the phosphatidylcholine fraction in plasma membranes of rat thymocytes and human blood lymphocytes was studied as well as its relationship to the activation of phosphoinositide-specific phosphodiesterase at early stages of mitogen-initiated phosphoinositide cycle. The data indicate th...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 61; no. 8; p. 1414
Main Authors:	Tadevosian, Iu V, Asatrian, L Iu, Batikian, T B, Karagezian, K G, Tadevosian, A Iu
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1996
Subjects:	Animals Cell Membrane - metabolism Cells, Cultured Concanavalin A - pharmacology Humans Kinetics Lymphocytes - metabolism Mitogens - pharmacology Phosphatidylcholines - metabolism Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols - metabolism Phosphoric Diester Hydrolases - metabolism Rats
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Summary:	Deacylation of the phosphatidylcholine fraction in plasma membranes of rat thymocytes and human blood lymphocytes was studied as well as its relationship to the activation of phosphoinositide-specific phosphodiesterase at early stages of mitogen-initiated phosphoinositide cycle. The data indicate that in lymphocyte membranes, enzymatic system of cascade deacylation of the phosphatidylcholine fraction includes calcium-activated phospholipase A1 and lysophospholipase. The enzyme system contributes to the rapid and reversible modification of the lipid bilayer of lymphocyte plasma membrane and can cooperate with phosphoinositide-specific phosphodiesterase during its activation at early stages of the initiation of phosphoinositide pathway during translocation of the external mitogenic signal.
ISSN:	0320-9725