Search Results - "Taddei, Angela"

Structure and function in the budding yeast nucleus by Taddei, Angela, Gasser, Susan M

“…Budding yeast, like other eukaryotes, carries its genetic information on chromosomes that are sequestered from other cellular constituents by a double…”
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Building silent compartments at the nuclear periphery: a recurrent theme by Meister, Peter, Taddei, Angela

“…In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome…”
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Single molecule microscopy reveals key physical features of repair foci in living cells by Miné-Hattab, Judith, Heltberg, Mathias, Villemeur, Marie, Guedj, Chloé, Mora, Thierry, Walczak, Aleksandra M, Dahan, Maxime, Taddei, Angela

“…In response to double strand breaks (DSB), repair proteins accumulate at damaged sites, forming membrane-less sub-compartments or foci. Here we explored the…”
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Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status by Batté, Amandine, Brocas, Clémentine, Bordelet, Hélène, Hocher, Antoine, Ruault, Myriam, Adjiri, Adouda, Taddei, Angela, Dubrana, Karine

“…Homologous recombination (HR) is a conserved mechanism that repairs broken chromosomes via intact homologous sequences. How different genomic, chromatin and…”
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Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination by Neumann, Frank R, Dion, Vincent, Gehlen, Lutz R, Tsai-Pflugfelder, Monika, Schmid, Roger, Taddei, Angela, Gasser, Susan M

“…Chromatin in the interphase nucleus moves in a constrained random walk. Despite extensive study, the molecular causes of such movement and its impact on…”
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Nuclear pore association confers optimal expression levels for an inducible yeast gene by Gasser, Susan M, Taddei, Angela, Hediger, Florence, Kalck, Veronique, Schober, Heiko, Cubizolles, Fabien, Van Houwe, Griet

“…The organization of the nucleus into subcompartments creates microenvironments that are thought to facilitate distinct nuclear functions. In budding yeast,…”
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Physical observables to determine the nature of membrane-less cellular sub-compartments by Heltberg, Mathias L, Miné-Hattab, Judith, Taddei, Angela, Walczak, Aleksandra M, Mora, Thierry

“…The spatial organization of complex biochemical reactions is essential for the regulation of cellular processes. Membrane-less structures called foci…”
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Spatial reorganization of telomeres in long-lived quiescent cells by Guidi, Micol, Ruault, Myriam, Marbouty, Martial, Loïodice, Isabelle, Cournac, Axel, Billaudeau, Cyrille, Hocher, Antoine, Mozziconacci, Julien, Koszul, Romain, Taddei, Angela

“…The spatiotemporal behavior of chromatin is an important control mechanism of genomic function. Studies in Saccharomyces cerevisiae have broadly contributed to…”
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The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion by Taddei, Angela, Van Houwe, Griet, Nagai, Shigeki, Erb, Ionas, van Nimwegen, Erik, Gasser, Susan M

“…Budding yeast telomeres and cryptic mating-type loci are enriched at the nuclear envelope, forming foci that sequester silent information regulators (SIR…”
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Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast by Ruault, Myriam, De Meyer, Arnaud, Loïodice, Isabelle, Taddei, Angela

“…A general feature of the nucleus is the organization of repetitive deoxyribonucleic acid sequences in clusters concentrating silencing factors. In budding…”
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Tight protein-DNA interactions favor gene silencing by Dubarry, Marion, Loïodice, Isabelle, Chen, Chunlong L, Thermes, Claude, Taddei, Angela

“…The heterochromatin-like structure formed by the yeast silent information regulator complex (SIR) represses transcription at the silent mating type loci and…”
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An Inducible System for Silencing Establishment Reveals a Stepwise Mechanism in Which Anchoring at the Nuclear Periphery Precedes Heterochromatin Formation by Loïodice, Isabelle, Garnier, Mickael, Nikolov, Ivaylo, Taddei, Angela

“…In eukaryotic cells, silent chromatin is mainly found at the nuclear periphery forming subnuclear compartments that favor silencing establishment. Here, we set…”
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Spatial telomere organization and clustering in yeast Saccharomyces cerevisiae nucleus is generated by a random dynamics of aggregation-dissociation by Hozé, Nathanaël, Ruault, Myriam, Amoruso, Carlo, Taddei, Angela, Holcman, David

“…Spatial and temporal behavior of chromosomes and their regulatory proteins is a key control mechanism in genomic function. This is exemplified by the…”
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Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins by Taddei, Angela, Hediger, Florence, Neumann, Frank R, Bauer, Christoph, Gasser, Susan M

“…In budding yeast, the nuclear periphery forms a subcompartment in which telomeres cluster and SIR proteins concentrate. To identify the proteins that mediate…”
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Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component by Almouzni, Geneviève, Maison, Christèle, Bailly, Delphine, Peters, Antoine H.F.M, Quivy, Jean-Pierre, Roche, Danièle, Taddei, Angela, Lachner, Monika, Jenuwein, Thomas

“…Post-translational modification of histone tails is thought to modulate higher-order chromatin structure. Combinations of modifications including acetylation,…”
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The function of nuclear architecture: a genetic approach by Taddei, Angela, Hediger, Florence, Neumann, Frank R, Gasser, Susan M

“…Eukaryotic genomes are distributed on linear chromosomes that are grouped together in the nucleus, an organelle separated from the cytoplasm by a…”
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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases by Almouzni, Geneviève, Taddei, Angela, Maison, Christèle, Roche, Danièle

“…Histone modifications might act to mark and maintain functional chromatin domains during both interphase and mitosis. Here we show that pericentric…”
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Re-positioning genes to the nuclear envelope in mammalian cells: impact on transcription by Ruault, Myriam, Dubarry, Marion, Taddei, Angela

“…The spatial organization of the genome within the nucleus is thought to contribute to genome functions. A key component of the nuclear architecture is the…”
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The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? by Taddei, Angela, Roche, Danièle, Bickmore, Wendy A., Almouzni, Geneviève

“…Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce…”
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Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores by Yoshida, Takahito, Shimada, Kenji, Oma, Yukako, Kalck, Véronique, Akimura, Kazumi, Taddei, Angela, Iwahashi, Hitoshi, Kugou, Kazuto, Ohta, Kunihiro, Gasser, Susan M, Harata, Masahiko

“…Actin-related proteins are ubiquitous components of chromatin remodelers and are conserved from yeast to man. We have examined the role of the budding yeast…”
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