Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes

In Western Amazon areas with perennial malaria transmission, long term residents frequently develop partial immunity to malarial infection caused either by Plasmodium falciparum or P. vivax, resulting in a considerable number of non-symptomatically infected individuals. For yet unknown reasons, thes...

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Published in:	Memórias do Instituto Oswaldo Cruz Vol. 102; no. 3; pp. 293 - 298
Main Authors:	Martha, Rosimeire Cristina dalla, Tada, Mauro Sughiro, de Mattos Ferreira, Ricardo Godoi, da Silva, Luiz Hildebrando Pereira, Wunderlich, Gerhard
Format:	Journal Article
Language:	English
Published:	Brazil Fundação Oswaldo Cruz, Fiocruz 01-06-2007 Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ)
Subjects:	Alleles Animals Brazil DNA, Protozoan - genetics Genetic Markers Genotype genotyping Humans Malaria, Falciparum - parasitology Microsatellite Repeats - genetics microsatellites non-symptomatic malaria non-symptomatic malaria - Plasmodium falciparum - microsatellites - genotyping PARASITOLOGY Plasmodium falciparum Plasmodium falciparum - genetics Polymerase Chain Reaction Risk Factors TROPICAL MEDICINE Brazil microsatellites Plasmodium falciparum non-symptomatic malaria genotyping
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Summary:	In Western Amazon areas with perennial malaria transmission, long term residents frequently develop partial immunity to malarial infection caused either by Plasmodium falciparum or P. vivax, resulting in a considerable number of non-symptomatically infected individuals. For yet unknown reasons, these individuals sporadically develop symptomatic malaria. In order to identify if determined parasite genotypes, defined by a combination of eleven microsatellite markers, were associated to different outcomes symptomatic or asymptomatic malaria we analyzed infecting P. falciparum parasites in a suburban riverine population. Despite of detecting a high degree of diversity in the analyzed samples, several microsatellite marker alleles appeared accumulated in parasites from non-symptomatic infections. This result may be interpreted that a number of microsatellites, which are not directly related to antigenic features, could be associated to the outcome of malarial infection. The result may also point to a low frequency of recombinatorial events which otherwise would dissociate genes under strong immune pressure from the relatively neutral microsatellite loci.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1678-8060 0074-0276 1678-8060
DOI:	10.1590/S0074-02762007005000044