Search Results - "Tachiwana, Hiroaki"

Nuclear microenvironment in cancer: Control through liquid‐liquid phase separation by Nozawa, Ryu‐Suke, Yamamoto, Tatsuro, Takahashi, Motoko, Tachiwana, Hiroaki, Maruyama, Reo, Hirota, Toru, Saitoh, Noriko

“…The eukaryotic nucleus is not a homogenous single‐spaced but a highly compartmentalized organelle, partitioned by various types of membraneless structures,…”
Get full text

Gene regulation by non-coding RNAs in the 3D genome architecture by Tachiwana, Hiroaki, Yamamoto, Tatsuro, Saitoh, Noriko

“…Appropriate gene expression is essential for producing the correct amount of proteins at the right time, which is critical for living organisms. In the…”
Get full text

Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome by Takizawa, Yoshimasa, Ho, Cheng-Han, Tachiwana, Hiroaki, Matsunami, Hideyuki, Kobayashi, Wataru, Suzuki, Midori, Arimura, Yasuhiro, Hori, Tetsuya, Fukagawa, Tatsuo, Ohi, Melanie D., Wolf, Matthias, Kurumizaka, Hitoshi

“…The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification. CENP-A forms a characteristic nucleosome and dictates the…”
Get full text

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX by Lacoste, Nicolas, Woolfe, Adam, Tachiwana, Hiroaki, Garea, Ana Villar, Barth, Teresa, Cantaloube, Sylvain, Kurumizaka, Hitoshi, Imhof, Axel, Almouzni, Geneviève

“…Centromeres are essential for ensuring proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone…”
Get full text

Histone H2A variants confer specific properties to nucleosomes and impact on chromatin accessibility by Osakabe, Akihisa, Lorković, Zdravko J, Kobayashi, Wataru, Tachiwana, Hiroaki, Yelagandula, Ramesh, Kurumizaka, Hitoshi, Berger, Frédéric

“…Abstract In eukaryotes, variants of core histone H2A are selectively incorporated in distinct functional domains of chromatin and are distinguished by…”
Get full text

Structural Analysis of the Hexasome, Lacking One Histone H2A/H2B Dimer from the Conventional Nucleosome by Arimura, Yasuhiro, Tachiwana, Hiroaki, Oda, Takashi, Sato, Mamoru, Kurumizaka, Hitoshi

“…Genomic DNA is packaged into chromatin in eukaryotes, and the nucleosome is the fundamental unit of chromatin. The canonical nucleosome is the octasome, which…”
Get full text

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism by Arimura, Yasuhiro, Tachiwana, Hiroaki, Takagi, Hiroki, Hori, Tetsuya, Kimura, Hiroshi, Fukagawa, Tatsuo, Kurumizaka, Hitoshi

“…Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional…”
Get full text

Crystal structure of the human centromeric nucleosome containing CENP-A by Tachiwana, Hiroaki, Kagawa, Wataru, Shiga, Tatsuya, Osakabe, Akihisa, Miya, Yuta, Saito, Kengo, Hayashi-Takanaka, Yoko, Oda, Takashi, Sato, Mamoru, Park, Sam-Yong, Kimura, Hiroshi, Kurumizaka, Hitoshi

“…The centromeric nucleosome Centromeres are epigenetically marked by the assembly of nucleosomes containing CENP-A, a centromere-specific histone H3 variant…”
Get full text

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T by Tachiwana, Hiroaki, Kagawa, Wataru, Osakabe, Akihisa, Kawaguchi, Koichiro, Shiga, Tatsuya, Hayashi-Takanaka, Yoko, Kimura, Hiroshi, Kurumizaka, Hitoshi, Richmond, Timothy J.

“…A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for…”
Get full text

Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones by Sato, Shoko, Takizawa, Yoshimasa, Hoshikawa, Fumika, Dacher, Mariko, Tanaka, Hiroki, Tachiwana, Hiroaki, Kujirai, Tomoya, Iikura, Yukari, Ho, Cheng-Han, Adachi, Naruhiko, Patwal, Indu, Flaus, Andrew, Kurumizaka, Hitoshi

“…Abstract Giardia lamblia is a pathogenic unicellular eukaryotic parasite that causes giardiasis. Its genome encodes the canonical histones H2A, H2B, H3, and…”
Get full text

Two arginine residues suppress the flexibility of nucleosomal DNA in the canonical nucleosome core by Kono, Hidetoshi, Shirayama, Kazuyoshi, Arimura, Yasuhiro, Tachiwana, Hiroaki, Kurumizaka, Hitoshi

“…The dynamics of nucleosomes containing either canonical H3 or its centromere-specific variant CENP-A were investigated using molecular dynamics simulations…”
Get full text

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity by Roulland, Yohan, Ouararhni, Khalid, Naidenov, Mladen, Ramos, Lorrie, Shuaib, Muhammad, Syed, Sajad Hussain, Lone, Imtiaz Nizar, Boopathi, Ramachandran, Fontaine, Emeline, Papai, Gabor, Tachiwana, Hiroaki, Gautier, Thierry, Skoufias, Dimitrios, Padmanabhan, Kiran, Bednar, Jan, Kurumizaka, Hitoshi, Schultz, Patrick, Angelov, Dimitar, Hamiche, Ali, Dimitrov, Stefan

“…CENP-A is a histone variant, which replaces histone H3 at centromeres and confers unique properties to centromeric chromatin. The crystal structure of CENP-A…”
Get full text

Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay by Tachiwana, Hiroaki, Dacher, Mariko, Maehara, Kazumitsu, Harada, Akihito, Seto, Yosuke, Katayama, Ryohei, Ohkawa, Yasuyuki, Kimura, Hiroshi, Kurumizaka, Hitoshi, Saitoh, Noriko

“…In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome,…”
Get full text

Incorporation and influence of Leishmania histone H3 in chromatin by Dacher, Mariko, Tachiwana, Hiroaki, Horikoshi, Naoki, Kujirai, Tomoya, Taguchi, Hiroyuki, Kimura, Hiroshi, Kurumizaka, Hitoshi

“…Immunopathologies caused by Leishmania cause severe human morbidity and mortality. This protozoan parasite invades and persists inside host cells, resulting in…”
Get full text

Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA by Yamamoto, Tatsuro, Sakamoto, Chiyomi, Tachiwana, Hiroaki, Kumabe, Mitsuru, Matsui, Toshiro, Yamashita, Tadatoshi, Shinagawa, Masatoshi, Ochiai, Koji, Saitoh, Noriko, Nakao, Mitsuyoshi

“…Long-term estrogen deprivation (LTED) of an estrogen receptor (ER) α-positive breast cancer cell line recapitulates cancer cells that have acquired…”
Get full text

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis by Ueda, Jun, Harada, Akihito, Urahama, Takashi, Machida, Shinichi, Maehara, Kazumitsu, Hada, Masashi, Makino, Yoshinori, Nogami, Jumpei, Horikoshi, Naoki, Osakabe, Akihisa, Taguchi, Hiroyuki, Tanaka, Hiroki, Tachiwana, Hiroaki, Yao, Tatsuma, Yamada, Minami, Iwamoto, Takashi, Isotani, Ayako, Ikawa, Masahito, Tachibana, Taro, Okada, Yuki, Kimura, Hiroshi, Ohkawa, Yasuyuki, Kurumizaka, Hitoshi, Yamagata, Kazuo

“…Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse…”
Get full text

Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer by Horikoshi, Naoki, Tachiwana, Hiroaki, Kagawa, Wataru, Osakabe, Akihisa, Matsumoto, Syota, Iwai, Shigenori, Sugasawa, Kaoru, Kurumizaka, Hitoshi

“…The cyclobutane pyrimidine dimer (CPD) is induced in genomic DNA by ultraviolet (UV) light. In mammals, this photolesion is primarily induced within…”
Get full text

Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome by Osakabe, Akihisa, Tachiwana, Hiroaki, Kagawa, Wataru, Horikoshi, Naoki, Matsumoto, Syota, Hasegawa, Mayu, Matsumoto, Naoyuki, Toga, Tatsuya, Yamamoto, Junpei, Hanaoka, Fumio, Thomä, Nicolas H., Sugasawa, Kaoru, Iwai, Shigenori, Kurumizaka, Hitoshi

“…UV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6–4PP lesions through a base flipping mechanism. As genomic DNA is almost…”
Get full text

Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains by Iwasaki, Wakana, Tachiwana, Hiroaki, Kawaguchi, Koichiro, Shibata, Takehiko, Kagawa, Wataru, Kurumizaka, Hitoshi

“…Post-translational modifications (PTMs) of histones play important roles in regulating the structure and function of chromatin in eukaryotes. Although histone…”
Get full text

Contribution of histone N-terminal tails to the structure and stability of nucleosomes by Iwasaki, Wakana, Miya, Yuta, Horikoshi, Naoki, Osakabe, Akihisa, Taguchi, Hiroyuki, Tachiwana, Hiroaki, Shibata, Takehiko, Kagawa, Wataru, Kurumizaka, Hitoshi

“…Histones are the protein components of the nucleosome, which forms the basic architecture of eukaryotic chromatin. Histones H2A, H2B, H3, and H4 are composed…”
Get full text