Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken

Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken

Recently, it has been suggested that leptin plays an important role in regulation of food intake and metabolism in rats and mice, however, the effect of central administration of leptin on food intake in chicks has not been reported. We have investigated the anorexigenic effect of leptin administere...

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Bibliographic Details
Published in:Brain research Vol. 817; no. 1-2; pp. 196 - 198
Main Authors: Bungo, Takashi, Shimojo, Masataka, Masuda, Yasuhisa, Tachibanab, Tetsuya, Tanaka, Shin-ji, Sugahara, Kunio, Furuse, Mitsuhiro
Format: Journal Article
Language:English
Published: London Elsevier B.V 30-01-1999
Amsterdam Elsevier
New York, NY
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Broiler
Chickens
Feeding Behavior - drug effects
Feeding. Feeding behavior
Food intake
Fundamental and applied biological sciences. Psychology
Injections, Intraventricular
Intracerebroventricular administration
Leptin
Male
Mice
Mouse leptin
Obesity
Proteins - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
White Leghorn
White Leghorn
Mouse leptin
Intracerebroventricular administration
Food intake
Broiler
Vertebrata
Mammalia
Mouse
Leptin
Rodentia
Intracerebral administration
Chicken
Aves
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Summary:Recently, it has been suggested that leptin plays an important role in regulation of food intake and metabolism in rats and mice, however, the effect of central administration of leptin on food intake in chicks has not been reported. We have investigated the anorexigenic effect of leptin administered by intracerebroventricular (i.c.v.) injection in chicks using mouse leptin, which shows 97% homology to chicken leptin. Three experiments were conducted. After being deprived of food for 3 h, male broiler chicks were administered leptin by i.c.v. injection at dose levels of 0, 0.2, 1.0 and 5.0 μg (Experiment 1) or 0, 2.5 and 5.0 μg (Experiment 2). The birds were allowed free access to the diet for 2 h (Experiment 1) and 24 h (Experiment 2) after treatment. Male Single Comb White Leghorn chicks were used in Experiment 3 and were treated in the same manner as in Experiment 1. In all experiments, central administration of mouse leptin did not influence food intake in the time periods examined. It appears that either mouse leptin does not bind to the chicken leptin receptor or in the chicken brain the leptin receptor may be absent.
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ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)01223-2