Search Results - "Tabruyn, Sebastien P"

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy by Halkein, Julie, Tabruyn, Sebastien P, Ricke-Hoch, Melanie, Haghikia, Arash, Nguyen, Ngoc-Quynh-Nhu, Scherr, Michaela, Castermans, Karolien, Malvaux, Ludovic, Lambert, Vincent, Thiry, Marc, Sliwa, Karen, Noel, Agnes, Martial, Joseph A, Hilfiker-Kleiner, Denise, Struman, Ingrid

“…Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the…”
Get full text

GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
Get full text

Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors by Sennino, Barbara, Ishiguro-Oonuma, Toshina, Wei, Ying, Naylor, Ryan M, Williamson, Casey W, Bhagwandin, Vikash, Tabruyn, Sebastien P, You, Weon-Kyoo, Chapman, Harold A, Christensen, James G, Aftab, Dana T, McDonald, Donald M

“…Invasion and metastasis increase after the inhibition of VEGF signaling in some preclinical tumor models. In the present study we asked whether selective VEGF…”
Get more information

Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System by Verhaeghe, Catherine, Talikka, Marja, Sewer, Alain, Sierro, Nicolas, Auberson, Mehdi, Peric, Dariusz, Bornand, David, Dulize, Remi, Guedj, Emmanuel, Nef, Patrick, Tabruyn, Sebastien P, Hoeng, Julia, Peitsch, Manuel C, Lo Sasso, Giuseppe

“…Inflammatory bowel disease (IBD) refers to chronic intestinal immune-mediated diseases including two main disease manifestations: ulcerative colitis (UC) and…”
Get full text

Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways by Verhaeghe, Catherine, Remouchamps, Caroline, Hennuy, Benoît, Vanderplasschen, Alain, Chariot, Alain, Tabruyn, Sebastien P., Oury, Cecile, Bours, Vincent

“…In cystic fibrosis (CF) patients, pulmonary inflammation is a major cause of morbidity and mortality and may precede bacterial colonization. The aim of the…”
Get full text

PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6high uterine leiomyosarcoma to PD‐1 blockade by De Wispelaere, Wout, Annibali, Daniela, Tuyaerts, Sandra, Messiaen, Julie, Antoranz, Asier, Shankar, Gautam, Dubroja, Nikolina, Herreros‐Pomares, Alejandro, Baiden‐Amissah, Regina E. M., Orban, Marie‐Pauline, Delfini, Marcello, Berardi, Emanuele, Van Brussel, Thomas, Schepers, Rogier, Philips, Gino, Boeckx, Bram, Baietti, Maria Francesca, Congedo, Luigi, HoWangYin, Kiave Yune, Bayon, Emilie, Van Rompuy, Anne‐Sophie, Leucci, Eleonora, Tabruyn, Sebastien P., Bosisio, Francesca, Mazzone, Massimiliano, Lambrechts, Diether, Amant, Frédéric

“…Background Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB)…”
Get full text

The antiangiogenic 16K prolactin impairs functional tumor neovascularization by inhibiting vessel maturation by Nguyen, Ngoc-Quynh-Nhu, Castermans, Karolien, Berndt, Sarah, Herkenne, Stephanie, Tabruyn, Sebastien P, Blacher, Silvia, Lion, Michelle, Noel, Agnes, Martial, Joseph A, Struman, Ingrid

“…Angiogenesis, the formation of new blood vessels from existing vasculature, plays an essential role in tumor growth, invasion, and metastasis. 16K hPRL, the…”
Get full text

Intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells by Verhaeghe, Catherine, Tabruyn, Sebastien P., Oury, Cecile, Bours, Vincent, Griffioen, Arjan W.

“…Cystic fibrosis is a common genetic disorder characterized by a severe lung inflammation and fibrosis leading to the patient’s death. Enhanced angiogenesis in…”
Get full text

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer by Bovy, Nicolas, Blomme, Benoît, Frères, Pierre, Dederen, Stella, Nivelles, Olivier, Lion, Michelle, Carnet, Oriane, Martial, Joseph A, Noël, Agnès, Thiry, Marc, Jérusalem, Guy, Josse, Claire, Bours, Vincent, Tabruyn, Sébastien P, Struman, Ingrid

“…The interaction between tumor cells and their microenvironment is an essential aspect of tumor development. Therefore, understanding how this microenvironment…”
Get full text

Prolactin/Growth Hormone-Derived Antiangiogenic Peptides Highlight a Potential Role of Tilted Peptides in Angiogenesis by Nguyen, Ngoc-Quynh-Nhu, Tabruyn, Sebastien P., Lins, Laurence, Lion, Michelle, Cornet, Anne M., Lair, Florence, Rentier-Delrue, Francoise, Brasseur, Robert, Martial, Joseph A., Struman, Ingrid

“…Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity…”
Get full text

Molecular pathways of angiogenesis inhibition by Tabruyn, Sebastien P., Griffioen, Arjan W.

“…A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval…”
Get full text

NF-κB: a new player in angiostatic therapy by Tabruyn, Sebastien P., Griffioen, Arjan W.

“…Angiogenesis is considered a promising target in the treatment of cancer. Most of the angiogenesis inhibitors in late-stage clinical testing or approved for…”
Get full text

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity by Wentink, Madelon Q., Hackeng, Tilman M., Tabruyn, Sebastien P., Puijk, Wouter C., Schwamborn, Klaus, Altschuh, Daniele, Meloen, Rob H., Schuurman, Teun, Griffioen, Arjan W., Timmerman, Peter

“…Therapeutic targeting of the VEGF signaling axis by the VEGF-neutralizing monoclonal antibody bevacizumab has clearly demonstrated clinical benefit in cancer…”
Get full text

Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation by Tabruyn, Sebastien P, Colton, Katharine, Morisada, Tohru, Fuxe, Jonas, Wiegand, Stanley J, Thurston, Gavin, Coyle, Anthony J, Connor, Jane, McDonald, Donald M

“…Vascular remodeling is a feature of chronic inflammation during which capillaries transform into venules that expand the region of the vasculature in which…”
Get full text

PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6 high uterine leiomyosarcoma to PD-1 blockade by De Wispelaere, Wout, Annibali, Daniela, Tuyaerts, Sandra, Messiaen, Julie, Antoranz, Asier, Shankar, Gautam, Dubroja, Nikolina, Herreros-Pomares, Alejandro, Baiden-Amissah, Regina E M, Orban, Marie-Pauline, Delfini, Marcello, Berardi, Emanuele, Van Brussel, Thomas, Schepers, Rogier, Philips, Gino, Boeckx, Bram, Baietti, Maria Francesca, Congedo, Luigi, HoWangYin, Kiave Yune, Bayon, Emilie, Van Rompuy, Anne-Sophie, Leucci, Eleonora, Tabruyn, Sebastien P, Bosisio, Francesca, Mazzone, Massimiliano, Lambrechts, Diether, Amant, Frédéric

“…Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB) has proven…”
Get full text

Cellular Source and Amount of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Tumors Determine Response to Angiogenesis Inhibitors by SENNINO, Barbara, KUHNERT, Frank, TABRUYN, Sebastien P, MANCUSO, Michael R, HU-LOWE, Dana D, KUO, Calvin J, MCDONALD, Donald M

“…Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and their receptors are important targets in cancer therapy based on…”
Get full text

Angiostatic activity of the antitumor cytokine interleukin-21 by Castermans, Karolien, Tabruyn, Sebastien P., Zeng, Rong, van Beijnum, Judy R., Eppolito, Cheryl, Leonard, Warren J., Shrikant, Protul A., Griffioen, Arjan W.

“…Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer…”
Get full text

MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells by Tabruyn, Sebastien P., Hansen, Sylvain, Ojeda-Fernández, Maria-Luisa, Bovy, Nicolas, Zarrabeitia, Roberto, Recio-Poveda, Lucia, Bernabéu, Carmelo, Martial, Joseph A., Botella, Luisa-Maria, Struman, Ingrid

“…Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by arteriovenous malformations and hemorrhages. This vascular…”
Get full text

The Angiostatic 16K Human Prolactin Overcomes Endothelial Cell Anergy and Promotes Leukocyte Infiltration via Nuclear Factor-κB Activation by Tabruyn, Sébastien P, Sabatel, Céline, Nguyen, Ngoc-Quynh-Nhu, Verhaeghe, Catherine, Castermans, Karolien, Malvaux, Ludovic, Griffioen, Arjan W, Martial, Joseph A, Struman, Ingrid

“…The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent angiostatic factor that inhibits tumor growth in mouse models. Using microarray…”
Get full text

Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation by Fuxe, Jonas, Lashnits, Erin, O'Brien, Shaun, Baluk, Peter, Tabruyn, Sebastien P, Kuhnert, Frank, Kuo, Calvin, Thurston, Gavin, McDonald, Donald M

“…Vascular endothelial growth factor (VEGF) is a key angiogenic factor in tumors, but less is known about what drives vascular remodeling in inflammation, where…”
Get full text