Search Results - "Tabrizi, S J"

Huntington's disease: a clinical review by McColgan, P., Tabrizi, S. J.

“…Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG trinucleotide repeat expansion in the huntingtin…”
Get full text

Proteome-based plasma biomarkers for Alzheimer's disease by Hye, A., Lynham, S., Thambisetty, M., Causevic, M., Campbell, J., Byers, H. L., Hooper, C., Rijsdijk, F., Tabrizi, S. J., Banner, S., Shaw, C. E., Foy, C., Poppe, M., Archer, N., Hamilton, G., Powell, J., Brown, R. G., Sham, P., Ward, M., Lovestone, S.

“…Alzheimer's disease is a common and devastating disease for which there is no readily available biomarker to aid diagnosis or to monitor disease progression…”
Get full text

Automatic detection of preclinical neurodegeneration : Presymptomatic Huntington disease by KLÖPPEL, S, CHU, C, TAN, G. C, DRAGANSKI, B, JOHNSON, H, PAULSEN, J. S, KIENZLE, W, TABRIZI, S. J, ASHBURNER, J, FRACKOWIAK, R. S. J

“…Treatment of neurodegenerative diseases is likely to be most beneficial in the very early, possibly preclinical stages of degeneration. We explored the…”
Get full text

Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease by STURROCK, A, LAULE, C, MACKAY, A. L, LEAVITT, B. R, DECOLONGON, J, DAR SANTOS, R, COLEMAN, A. J, CREIGHTON, S, BECHTEL, N, REILMANN, R, HAYDEN, M. R, TABRIZI, S. J

“…To evaluate in vivo brain metabolite differences in control subjects, individuals with premanifest Huntington disease (pre-HD), and individuals with early HD…”
Get full text

Tapping linked to function and structure in premanifest and symptomatic Huntington disease by BECHTEL, N, SCAHILL, R. I, SALAT, D. H, DURR, A, LEAVITT, B. R, ROOS, R. A. C, LANDWEHRMEYER, G. B, LANGBEHN, D. R, STOUT, J. C, TABRIZI, S. J, REILMANN, R, ROSAS, H. D, ACHARYA, T, VAN DEN BOGAARD, S. J. A, JAUFFRET, C, SAY, M. J, STURROCK, A, JOHNSON, H, ONORATO, C. E

“…Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are…”
Get full text

The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study by Sprengelmeyer, R, Orth, M, Müller, H-P, Wolf, R C, Grön, G, Depping, M S, Kassubek, J, Justo, D, Rees, E M, Haider, S, Cole, J H, Hobbs, N Z, Roos, R A C, Dürr, A, Tabrizi, S J, Süssmuth, S D, Landwehrmeyer, G B

“…Depressive symptoms are prominent psychopathological features of Huntington's disease (HD), making a negative impact on social functioning and well-being. We…”
Get more information

Pitfalls in the Use of Voxel-Based Morphometry as a Biomarker: Examples from Huntington Disease by HENLEY, S. M. D, RIDGWAY, G. R, SCAHILL, R. I, KLÖPPEL, S, TABRIZI, S. J, FOX, N. C, KASSUBEK, J

“…VBM is increasingly used in the study of neurodegeneration, and recently there has been interest in its potential as a biomarker. However, although it is…”
Get full text

Onset and Progression of Pathologic Atrophy in Huntington Disease: A Longitudinal MR Imaging Study by HOBBS, N. Z, BARNES, J, FROST, C, HENLEY, S. M. D, WILD, E. J, MACDONALD, K, BARKER, R. A, SCAHILL, R. I, FOX, N. C, TABRIZI, S. J

“…Longitudinal MR imaging measures provide an opportunity to track progression in HD before the emergence of clinical symptoms. This may prove useful in…”
Get full text

The differential diagnosis of chorea by Wild, E J, Tabrizi, S J

“…Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In…”
Get more information

Biochemical abnormalities and excitotoxicity in Huntington's disease brain by Tabrizi, S. J., Cleeter, M. W. J., Xuereb, J., Taanman, J.-W., Cooper, J. M., Schapira, A. H. V.

“…The physiological role of huntingtin and the mechanisms by which the expanded CAG repeat in ITI5 and its polyglutamine stretch in mutant huntingtin induce…”
Get full text

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse by Tabrizi, S. J., Workman, J., Hart, P. E., Mangiarini, L., Mahal, A., Bates, G., Cooper, J. M., Schapira, A. H. V.

“…Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely…”
Get full text

Identification of an oculomotor biomarker of preclinical Huntington disease by GOLDING, C. V. P, DANCHAIVIJITR, C, HODGSON, T. L, TABRIZI, S. J, KENNARD, C

“…The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington…”
Get full text

High-dose creatine therapy for huntington disease : A 2-year clinical and MRS study by TABRIZI, S. J, BLAMIRE, A. M, MANNERS, D. N, RAJAGOPALAN, B, STYLES, P, SCHAPIRA, A. H. V, WARNER, T. T

Get full text

Mitochondria in the etiology and pathogenesis of Parkinson's disease by Schapira, A H, Gu, M, Taanman, J W, Tabrizi, S J, Seaton, T, Cleeter, M, Cooper, J M

“…Mitochondria play a critical role in cellular energy metabolism. The identification of a respiratory chain defect in Parkinson's disease (PD) provides not only…”
Get more information

Expression of mutant α-synuclein causes increased susceptibility to dopamine toxicity by TABRIZI, Sarah J, ORTH, Michael, WILKINSON, J. Max, TAANMAN, Jan-Willem, WARNER, Thomas T, COOPER, J. Mark, SCHAPIRA, Anthony H. V

“…Mutations of the alpha-synuclein gene have been identified in autosomal dominant Parkinson's disease (PD). Transgenic mice overexpressing wild-type human…”
Get full text

Creatine therapy for Huntington's disease: Clinical and MRS findings in a 1-year pilot study by TABRIZI, S. J, BLAMIRE, A. M, MANNERS, D. N, RAJAGOPALAN, B, STYLES, P, SCHAPIRA, A. H. V, WARNER, T. T

Get full text

Occupational risk factors for prostate cancer and benign prostatic hyperplasia: a case–control study in Western Australia by Fritschi, L, Glass, D C, Tabrizi, J S, Leavy, J E, Ambrosini, G L

“…Objective: To assess the association of selected occupational exposures with risk of prostate cancer and with risk of benign prostatic hyperplasia (BPH)…”
Get full text

Increased rate of whole-brain atrophy over 6 months in early Huntington disease by HENLEY, S. M. D, FROST, C, MACMANUS, D. G, WARNER, T. T, FOX, N. C, TABRIZI, S. J

“…The authors measured the rate of whole-brain atrophy over 6 months in 13 patients with early Huntington disease (HD) and seven matched controls. Patients with…”
Get full text

Apathy predicts rate of cognitive decline over 24 months in premanifest Huntington's disease by Andrews, S C, Langbehn, D R, Craufurd, D, Durr, A, Leavitt, B R, Roos, R A, Tabrizi, S J, Stout, J C

“…Cognitive impairment is a core feature of Huntington's disease (HD), however, the onset and rate of cognitive decline is highly variable. Apathy is the most…”
Get more information

α-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone by Orth, M., Tabrizi, S.J., Schapira, A.H.V., Cooper, J.M.

“…Mitochondrial dysfunction has been implicated in the aetiology of sporadic Parkinson's disease but its role in the disease mechanism is not clear. We have…”
Get full text