Enhancing photostability and minimizing volatility of a promising drug candidate

Microparticles (MP) composed of Ethylcellulose were developed to enhance the photostability and minimize the volatility of the antiprotozoal and antifungal compound 2-(2-nitrovinyl) furan (G-0). MP were prepared using the emulsion solvent evaporation method guided by a factorial design optimization...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of drug delivery science and technology Vol. 102; p. 106329
Main Authors:	Ruz Sanjuan, Vivian, Ribeiro, Clovis Augusto, Rodríguez Chanfrau, Jorge Enrique, Calvo Alonso, Amalia María, Tabosa do Egito, Evyvaldo Sócrates, Van den Mooter, Guy, de Oliveira, Anselmo Gomes
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2024
Subjects:	2-(2-nitrovinyl) furan Drug release Ethylcellulose Microparticles Photostabilization Volatilization Drug release Photostabilization 2-(2-nitrovinyl) furan Volatilization Microparticles Ethylcellulose
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Microparticles (MP) composed of Ethylcellulose were developed to enhance the photostability and minimize the volatility of the antiprotozoal and antifungal compound 2-(2-nitrovinyl) furan (G-0). MP were prepared using the emulsion solvent evaporation method guided by a factorial design optimization approach. Characterization of the formulations was conducted through Thermal Analysis, FE-SEM microscopy, and X-ray diffraction. Additionally, drug-polymer interactions were analyzed using NMR and FTIR spectroscopy, while drug volatility was assessed by TGA/DTA. Forced photodegradation studies were conducted using a UV-light cabinet, and HPLC was employed for monitoring. The basket method was utilized for the drug release procedure. The resulting MP exhibited spherical morphology, reduced drug crystallinity, and good compatibility, as confirmed by ATR-FTIR and 1H NMR analysis. Microencapsulation led to improved photostability and reduced drug volatilization of G-0. The in vitro release of G-0 from MP was slower compared to the crystalline drug, and the release kinetics were well described by the First-order model. Further investigations will focus on accelerated stability studies on microencapsulated G-0 and compatibility assessments with other excipients to facilitate incorporation in solid formulations. [Display omitted]
ISSN:	1773-2247
DOI:	10.1016/j.jddst.2024.106329