Search Results - "Tabernero, Josep"

The Role of VEGF and EGFR Inhibition: Implications for Combining Anti–VEGF and Anti–EGFR Agents by Tabernero, Josep

“…Multiple cellular pathways influence the growth and metastatic potential of tumors. This creates heterogeneity, redundancy, and the potential for tumors to…”
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Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients by Dienstmann, Rodrigo, Salazar, Ramon, Tabernero, Josep

“…For more than three decades, postoperative chemotherapy-initially fluoropyrimidines and more recently combinations with oxaliplatin-has reduced the risk of…”
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Clinical management of metastatic colorectal cancer in the era of precision medicine by Ciardiello, Fortunato, Ciardiello, Davide, Martini, Giulia, Napolitano, Stefania, Tabernero, Josep, Cervantes, Andres

“…Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second most common cause of cancer deaths. Initial clinical presentation as…”
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Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer by Dienstmann, Rodrigo, Vermeulen, Louis, Guinney, Justin, Kopetz, Scott, Tejpar, Sabine, Tabernero, Josep

“…Key Points Molecular alterations fostering the progression of colorectal cancers are acquired early in the carcinogenesis process, and there is…”
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Precision oncology in metastatic colorectal cancer — from biology to medicine by Di Nicolantonio, Federica, Vitiello, Pietro Paolo, Marsoni, Silvia, Siena, Salvatore, Tabernero, Josep, Trusolino, Livio, Bernards, Rene, Bardelli, Alberto

“…Remarkable progress has been made in the development of biomarker-driven targeted therapies for patients with multiple cancer types, including melanoma, breast…”
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Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer by Mayer, Robert J, Van Cutsem, Eric, Falcone, Alfredo, Yoshino, Takayuki, Garcia-Carbonero, Rocio, Mizunuma, Nobuyuki, Yamazaki, Kentaro, Shimada, Yasuhiro, Tabernero, Josep, Komatsu, Yoshito, Sobrero, Alberto, Boucher, Eveline, Peeters, Marc, Tran, Ben, Lenz, Heinz-Josef, Zaniboni, Alberto, Hochster, Howard, Cleary, James M, Prenen, Hans, Benedetti, Fabio, Mizuguchi, Hirokazu, Makris, Lukas, Ito, Masanobu, Ohtsu, Atsushi

“…TAS-102, a combination of trifluridine and tipiracil in which tipiracil interferes with the deactivation of trifluridine, improved overall and progression-free…”
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Development of PI3K inhibitors: lessons learned from early clinical trials by Rodon, Jordi, Dienstmann, Rodrigo, Serra, Violeta, Tabernero, Josep

“…Agents targeting the PI3K/AKT/mTOR pathway have been shown to be safe and effective in treating a number of tumour types. This Review outlines the background…”
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Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors by Dienstmann, Rodrigo, Rodon, Jordi, Serra, Violeta, Tabernero, Josep

“…The frequent activation of the PI3K/AKT/mTOR pathway in cancer, and its crucial role in cell growth and survival, has made it a much desired target for…”
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The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer by Janjigian, Yelena Y., Kawazoe, Akihito, Yañez, Patricio, Li, Ning, Lonardi, Sara, Kolesnik, Oleksii, Barajas, Olga, Bai, Yuxian, Shen, Lin, Tang, Yong, Wyrwicz, Lucjan S., Xu, Jianming, Shitara, Kohei, Qin, Shukui, Van Cutsem, Eric, Tabernero, Josep, Li, Lie, Shah, Sukrut, Bhagia, Pooja, Chung, Hyun Cheol

“…Human epidermal growth factor receptor 2 ( HER2 , also known as ERBB2 ) amplification or overexpression occurs in approximately 20% of advanced gastric or…”
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LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy by Pascual-García, Mónica, Bonfill-Teixidor, Ester, Planas-Rigol, Ester, Rubio-Perez, Carlota, Iurlaro, Raffaella, Arias, Alexandra, Cuartas, Isabel, Sala-Hojman, Ada, Escudero, Laura, Martínez-Ricarte, Francisco, Huber-Ruano, Isabel, Nuciforo, Paolo, Pedrosa, Leire, Marques, Carolina, Braña, Irene, Garralda, Elena, Vieito, María, Squatrito, Massimo, Pineda, Estela, Graus, Francesc, Espejo, Carmen, Sahuquillo, Juan, Tabernero, Josep, Seoane, Joan

“…Cancer response to immunotherapy depends on the infiltration of CD8 + T cells and the presence of tumor-associated macrophages within tumors. Still, little is…”
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies by Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

“…Response to standard oncologic treatment is limited in colorectal cancer. The gene expression-based consensus molecular subtypes (CMS) provide a new paradigm…”
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Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations by Tamborero, David, Rubio-Perez, Carlota, Deu-Pons, Jordi, Schroeder, Michael P, Vivancos, Ana, Rovira, Ana, Tusquets, Ignasi, Albanell, Joan, Rodon, Jordi, Tabernero, Josep, de Torres, Carmen, Dienstmann, Rodrigo, Gonzalez-Perez, Abel, Lopez-Bigas, Nuria

“…While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important…”
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Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer by Kopetz, Scott, Grothey, Axel, Yaeger, Rona, Van Cutsem, Eric, Desai, Jayesh, Yoshino, Takayuki, Wasan, Harpreet, Ciardiello, Fortunato, Loupakis, Fotios, Hong, Yong Sang, Steeghs, Neeltje, Guren, Tormod K, Arkenau, Hendrik-Tobias, Garcia-Alfonso, Pilar, Pfeiffer, Per, Orlov, Sergey, Lonardi, Sara, Elez, Elena, Kim, Tae-Won, Schellens, Jan H.M, Guo, Christina, Krishnan, Asha, Dekervel, Jeroen, Morris, Van, Calvo Ferrandiz, Aitana, Tarpgaard, L.S, Braun, Michael, Gollerkeri, Ashwin, Keir, Christopher, Maharry, Kati, Pickard, Michael, Christy-Bittel, Janna, Anderson, Lisa, Sandor, Victor, Tabernero, Josep

“…Colorectal cancers with BRAF mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF…”
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Impact of Prior Bevacizumab Treatment on VEGF-A and PlGF Levels and Outcome Following Second-Line Aflibercept Treatment: Biomarker Post Hoc Analysis of the VELOUR Trial by Van Cutsem, Eric, Paccard, Caroline, Chiron, Marielle, Tabernero, Josep

“…Aflibercept is a targeted anti-VEGF therapy used to treat patients with metastatic colorectal cancer (mCRC) following progression on oxaliplatin-based…”
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Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs by Markman, Ben, Dienstmann, Rodrigo, Tabernero, Josep

“…It is well established that the PI3K pathway plays a central role in various cellular processes that can contribute to the malignant phenotype. Accordingly,…”
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Fibroblast Growth Factor (FGF) Receptor/FGF Inhibitors: Novel Targets and Strategies for Optimization of Response of Solid Tumors by Hierro, Cinta, Rodon, Jordi, Tabernero, Josep

“…The fibroblast growth factor receptor (FGFR) pathway plays a major role in several biological processes, from organogenesis to metabolism homeostasis and…”
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Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid by Martínez-Ricarte, Francisco, Mayor, Regina, Martínez-Sáez, Elena, Rubio-Pérez, Carlota, Pineda, Estela, Cordero, Esteban, Cicuéndez, Marta, Poca, Maria A, López-Bigas, Nuria, Ramon Y Cajal, Santiago, Vieito, María, Carles, Joan, Tabernero, Josep, Vivancos, Ana, Gallego, Soledad, Graus, Francesc, Sahuquillo, Juan, Seoane, Joan

“…Diffuse gliomas are the most common primary tumor of the brain and include different subtypes with diverse prognosis. The genomic characterization of diffuse…”
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Molecular dissection of microsatellite instable colorectal cancer by Vilar, Eduardo, Tabernero, Josep

“…Colorectal cancer was one of the first solid tumors to be classified on the basis of molecular profiling. Microsatellite instability has allowed researchers to…”
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Genomic Medicine Frontier in Human Solid Tumors: Prospects and Challenges by Dienstmann, Rodrigo, Rodon, Jordi, Barretina, Jordi, Tabernero, Josep

“…Recent discoveries of genomic alterations that underlie and promote the malignant phenotype, together with an expanded repertoire of targeted agents, have…”
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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer by Bullman, Susan, Pedamallu, Chandra S., Sicinska, Ewa, Clancy, Thomas E., Zhang, Xiaoyang, Cai, Diana, Neuberg, Donna, Huang, Katherine, Guevara, Fatima, Nelson, Timothy, Chipashvili, Otari, Hagan, Timothy, Walker, Mark, Ramachandran, Aruna, Diosdado, Begoña, Serna, Garazi, Mulet, Nuria, Landolfi, Stefania, Ramon y Cajal, Santiago, Fasani, Roberta, Aguirre, Andrew J., Ng, Kimmie, Élez, Elena, Ogino, Shuji, Tabernero, Josep, Fuchs, Charles S., Hahn, William C., Nuciforo, Paolo, Meyerson, Matthew

“…Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent…”
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