Search Results - "Tabei, S M Ali"
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1
Entropy production rate is maximized in non-contractile actomyosin
Published in Nature communications (23-11-2018)“…The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain…”
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2
Distribution of directional change as a signature of complex dynamics
Published in Proceedings of the National Academy of Sciences - PNAS (03-12-2013)“…Analyses of random walks traditionally use the mean square displacement (MSD) as an order parameter characterizing dynamics. We show that the distribution of…”
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3
Stability and Stoichiometry of Bilayer Phospholipid–Cholesterol Complexes: Relationship to Cellular Sterol Distribution and Homeostasis
Published in Biochemistry (Easton) (08-10-2013)“…Is cholesterol distributed among intracellular compartments by passive equilibration down its chemical gradient? If so, its distribution should reflect the…”
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4
Distinguishing synaptic vesicle precursor navigation of microtubule ends with a single rate constant model
Published in Scientific reports (09-02-2021)“…Axonal motor driven cargo utilizes the microtubule cytoskeleton in order to direct cargo, such as synaptic vesicle precursors (SVP), to where they are needed…”
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5
Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data
Published in PLoS computational biology (01-03-2015)“…Robust methods for identifying patterns of expression in genome-wide data are important for generating hypotheses regarding gene function. To this end, several…”
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6
Dynamic motions of molecular motors in the actin cytoskeleton
Published in Cytoskeleton (Hoboken, N.J.) (01-11-2019)“…During intracellular transport, cellular cargos, such as organelles, vesicles, and proteins, are transported within cells. Intracellular transport plays an…”
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Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport
Published in Physical review. X (01-03-2016)“…Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal…”
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8
Intracellular transport of insulin granules is a subordinated random walk
Published in Proceedings of the National Academy of Sciences - PNAS (26-03-2013)“…We quantitatively analyzed particle tracking data on insulin granules expressing fluorescent fusion proteins in MIN6 cells to better understand the motions…”
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9
Dynamics and selective remodeling of the DNA-binding domains of RPA
Published in Nature structural & molecular biology (01-02-2019)“…Replication protein A (RPA) coordinates important DNA metabolic events by stabilizing single-stranded DNA (ssDNA) intermediates, activating the DNA-damage…”
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10
A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding
Published in Journal of lipid research (01-04-2023)“…Almost all the cholesterol in cellular membranes is associated with phospholipids in simple stoichiometric complexes. This limits the binding of sterol ligands…”
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11
A basic model for cell cholesterol homeostasis
Published in Traffic (Copenhagen, Denmark) (01-12-2021)“…Cells manage their cholesterol by negative feedback using a battery of sterol‐responsive proteins. How these activities are coordinated so as to specify the…”
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KERA: analysis tool for multi-process, multi-state single-molecule data
Published in Nucleic acids research (21-05-2021)“…Abstract Molecular machines within cells dynamically assemble, disassemble and reorganize. Molecular interactions between their components can be observed at…”
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Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV
Published in Vaccine (11-01-2012)“…Highlights ► We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo . ►…”
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14
Microtubule orientation and spacing within bundles is critical for long-range kinesin-1 motility
Published in Cytoskeleton (Hoboken, N.J.) (01-11-2014)“…Cells rely on active transport to quickly organize cellular cargo. How cells regulate transport is not fully understood. One proposed mechanism is that motor…”
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15
Estimating the Cholesterol Affinity of Integral Membrane Proteins from Experimental Data
Published in Biochemistry (Easton) (02-01-2024)“…The cholesterol affinities of many integral plasma membrane proteins have been estimated by molecular computation. However, these values lack experimental…”
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16
Effects of Intercalating Molecules on the Polymer Properties of DNA
Published in The journal of physical chemistry. B (01-10-2020)“…Atomic force microscopy (AFM) enables determination of physical properties from single DNA molecules. Insertion of aromatic molecules into the structure of DNA…”
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17
Human hnRNPA1 reorganizes telomere-bound replication protein A
Published in Nucleic acids research (26-09-2024)“…Human replication protein A (RPA) is a heterotrimeric ssDNA binding protein responsible for many aspects of cellular DNA metabolism. Dynamic interactions of…”
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18
Anomalous intracellular transport phases depend on cytoskeletal network features
Published in Physical review. E (01-06-2019)“…Intracellular transport in eukaryotic cells consists of phases of passive, diffusion-based transport and active, motor-driven transport along filaments that…”
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Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives
Published in Development (Cambridge) (15-07-2010)“…A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types…”
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20
Entrainment of a driven oscillator as a dynamical phase transition
Published in Physical review. E, Statistical, nonlinear, and soft matter physics (01-12-2011)“…Large deviation theory has emerged as the natural language with which to study transitions between dynamical phases, such as the glass transition. Here we use…”
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