Search Results - "Tabbo, Fabrizio"

Precision medicine in ALK rearranged NSCLC: A rapidly evolving scenario by Addeo, Alfredo, Tabbò, Fabrizio, Robinson, Tim, Buffoni, Lucio, Novello, Silvia

“…The identification of anaplastic lymphoma kinase (ALK) rearrangements in 2-5% of non-small cell lung cancer (NSCLC) patients led to the rapid clinical…”
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Upfront Management of ALK-Rearranged Metastatic Non-small Cell Lung Cancer: One Inhibitor Fits All? by Tabbò, Fabrizio, Passiglia, Francesco, Novello, Silvia

“…Purpose of Review Anaplastic lymphoma kinase (ALK) rearrangements represent a seldom event in non-small cell lung cancer (NSCLC). Given the oncogene…”
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Major breakthroughs in lung cancer adjuvant treatment: Looking beyond the horizon by Passiglia, Francesco, Bertaglia, Valentina, Reale, Maria Lucia, Delcuratolo, Marco Donatello, Tabbò, Fabrizio, Olmetto, Emanuela, Capelletto, Enrica, Bironzo, Paolo, Novello, Silvia

“…•The ADAURA study marked the advent of precision medicine and molecular biomarker testing to the early stages disease.•The IMPower-010 trial paved the way to…”
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Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures by Kotlov, Nikita, Bagaev, Alexander, Revuelta, Maria V, Phillip, Jude M, Cacciapuoti, Maria Teresa, Antysheva, Zoya, Svekolkin, Viktor, Tikhonova, Ekaterina, Miheecheva, Natalia, Kuzkina, Natalia, Nos, Grigorii, Tabbo, Fabrizio, Frenkel, Felix, Ghione, Paola, Tsiper, Maria, Almog, Nava, Fowler, Nathan, Melnick, Ari M, Leonard, John P, Inghirami, Giorgio, Cerchietti, Leandro

“…Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has…”
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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…A systematic characterization of the genetic alterations driving ALCLs has not been performed. By integrating massive sequencing strategies, we provide a…”
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Expanding anaplastic lymphoma kinase therapeutic indication to early stage non-small cell lung cancer by Tabbò, Fabrizio, Novello, Silvia

“…Oncogene-addicted non-small cell lung cancer (NSCLC) patients have been witnessing overwhelming therapeutic improvements, especially in advanced disease…”
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The expanding family of c-Met inhibitors in solid tumors: a comparative analysis of their pharmacologic and clinical differences by Fogli, Stefano, Tabbò, Fabrizio, Capuano, Annalisa, Del Re, Marzia, Passiglia, Francesco, Cucchiara, Federico, Scavone, Cristina, Gori, Veronica, Novello, Silvia, Schmidinger, Manuela, Danesi, Romano

“…[Display omitted] •Somatic c-Met mutations and/or amplifications have been observed in several solid tumors, including renal cell carcinoma and lung…”
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Immune-checkpoint inhibition in stage III unresectable NSCLC: Challenges and opportunities in the post-PACIFIC era by Passiglia, Francesco, Leone, Gianmarco, Olmetto, Emanuela, Delcuratolo, Marco Donatello, Tabbò, Fabrizio, Reale, Maria Lucia, Bertaglia, Valentina, Consito, Lorena, Bironzo, Paolo, Capelletto, Enrica, Novello, Silvia

“…•PACIFIC trial marked a new era in the treatment of stage III unresectable NSCLC.•Durvalumab consolidation following chemoradiation is the new standard of care…”
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Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won by Tabbò, Fabrizio, Reale, Maria Lucia, Bironzo, Paolo, Scagliotti, Giorgio V.

“…Anaplastic lymphoma kinase ( ALK ) translocations are responsible of neoplastic transformation in a limited subset of non-small cell lung cancer (NSCLC)…”
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Adjuvant epidermal growth factor receptor tyrosine kinase inhibitors: are we actually ready? by Tabbò, Fabrizio, Reale, Maria Lucia, Novello, Silvia

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Changing paradigms of non-small cell lung cancer treatment by Guerrera, Francesco, Tabbò, Fabrizio, Ruffini, Enrico, Bertoglio, Pietro

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Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma by Clozel, Thomas, Yang, ShaoNing, Elstrom, Rebecca L, Tam, Wayne, Martin, Peter, Kormaksson, Matthias, Banerjee, Samprit, Vasanthakumar, Aparna, Culjkovic, Biljana, Scott, David W, Wyman, Sarah, Leser, Micheal, Shaknovich, Rita, Chadburn, Amy, Tabbo, Fabrizio, Godley, Lucy A, Gascoyne, Randy D, Borden, Katherine L, Inghirami, Giorgio, Leonard, John P, Melnick, Ari, Cerchietti, Leandro

“…Although aberrant DNA methylation patterning is a hallmark of cancer, the relevance of targeting DNA methyltransferases (DNMT) remains unclear for most tumors…”
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How to design a randomized clinical trial: tips and tricks for conduct a successful study in thoracic disease domain by Guerrera, Francesco, Renaud, Stéphane, Tabbò, Fabrizio, Filosso, Pier Luigi

“…Randomized controlled trials (RCTs) are considered one of the highest level of evidence in clinical practice, due to their strong confidence and robustness in…”
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Oncogenic kinase fusions: an evolving arena with innovative clinical opportunities by Tabbò, Fabrizio, Pizzi, Marco, Kyriakides, Peter W, Ruggeri, Bruce, Inghirami, Giorgio

“…Cancer biology relies on intrinsic and extrinsic deregulated pathways, involving a plethora of intra-cellular and extra-cellular components. Tyrosine kinases…”
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Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis by Nottegar, Alessia, Tabbò, Fabrizio, Luchini, Claudio, Guerrera, Francesco, Gaudiano, Marcello, Bria, Emilio, Brunelli, Matteo, Chilosi, Marco, Inghirami, Giorgio

“…Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO…”
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Future perspectives from lung cancer pre-clinical models: new treatments are coming? by Bersani, Francesca, Morena, Deborah, Picca, Francesca, Morotti, Alessandro, Tabbò, Fabrizio, Bironzo, Paolo, Righi, Luisella, Taulli, Riccardo

“…Lung cancer currently stands out as both the most common and the most lethal type of cancer, the latter feature being partly explained by the fact that the…”
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Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma by Tabbò, Fabrizio, Ponzoni, Maurilio, Rabadan, Raul, Bertoni, Francesco, Inghirami, Giorgio

“…PURPOSE OF REVIEWAnaplastic large cell lymphomas (ALCLs) are rare entities whose somatic genetic lesions have been identified only in a subset of patients…”
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SELECTing adjuvant treatment in early stage epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer by Tabbò, Fabrizio, Reale, Maria Lucia, Ruffini, Enrico, Novello, Silvia, Guerrera, Francesco

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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

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Convergent Mutations and New Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Todaro, Maria, Boi, Michela, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Rossi, Davide, Mevellec, Laurence, Vialard, Jorge, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…Introduction. If the role of ALK chimeras is well known in the pathogenesis of ALK+ Anaplastic Large Cell Lymphoma (ALCL), the mechanisms leading to the…”
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