Search Results - "Tabares, Leandro C."

Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease by Belluzzi, Elisa, Bisaglia, Marco, Lazzarini, Elisabetta, Tabares, Leandro C, Beltramini, Mariano, Bubacco, Luigi

“…Mitochondrial dysfunction and oxidative stress are considered central in dopaminergic neurodegeneration in Parkinson's disease (PD). Oxidative stress occurs…”
Get full text

An evolutionary path to altered cofactor specificity in a metalloenzyme by Barwinska-Sendra, Anna, Garcia, Yuritzi M., Sendra, Kacper M., Baslé, Arnaud, Mackenzie, Eilidh S., Tarrant, Emma, Card, Patrick, Tabares, Leandro C., Bicep, Cédric, Un, Sun, Kehl-Fie, Thomas E., Waldron, Kevin J.

“…Almost half of all enzymes utilize a metal cofactor. However, the features that dictate the metal utilized by metalloenzymes are poorly understood, limiting…”
Get full text

Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase by Goldsmith, Randall H, Tabares, Leandro C, Kostrz, Dorota, Dennison, Christopher, Aartsma, Thijs J, Canters, G. W, Moerner, W. E

“…Single-molecule measurements are a valuable tool for revealing details of enzyme mechanisms by enabling observation of unsynchronized behavior. However, this…”
Get full text

Tuning the Redox Properties of Manganese(II) and Its Implications to the Electrochemistry of Manganese and Iron Superoxide Dismutases by Sjödin, Martin, Gätjens, Jessica, Tabares, Leandro C, Thuéry, Pierre, Pecoraro, Vincent L, Un, Sun

“…Superoxide dismutases (SODs) catalyze the disproportionation of superoxide to dioxygen and hydrogen peroxide. The active metal sites of iron and manganese…”
Get full text

Tracking electrons in biological macromolecules: from ensemble to single molecule by Tabares, Leandro C, Gupta, Ankur, Aartsma, Thijs J, Canters, Gerard W

“…Nature utilizes oxido-reductases to cater to the energy demands of most biochemical processes in respiratory species. Oxido-reductases are capable of meeting…”
Get full text

Understanding the influence of the protein environment on the Mn(II) centers in Superoxide Dismutases using High-Field Electron Paramagnetic Resonance by Tabares, Leandro C., Gätjens, Jessica, Un, Sun

“…One of the most puzzling questions of manganese and iron superoxide dismutases (SODs) is what is the basis for their metal-specificity. This review summarizes…”
Get full text

pH-Dependent Structures of the Manganese Binding Sites in Oxalate Decarboxylase as Revealed by High-Field Electron Paramagnetic Resonance by Tabares, Leandro C, Gätjens, Jessica, Hureau, Christelle, Burrell, Matthew R, Bowater, Laura, Pecoraro, Vincent L, Bornemann, Stephen, Un, Sun

“…A high-field electron paramagnetic resonance (HFEPR) study of oxalate decarboxylase (OxdC) is reported. OxdC breaks down oxalate to carbon dioxide and formate…”
Get full text

In situ determination of manganese(II) speciation in Deinococcus radiodurans by high magnetic field EPR: detection of high levels of Mn(II) bound to proteins by Tabares, Leandro C, Un, Sun

“…High magnetic field high frequency electron paramagnetic resonance techniques were used to measure in situ Mn(II) speciation in Deinococcus radiodurans, a…”
Get full text

Using the Noncanonical Metallo-Amino Acid [Cu(II)(2,2′-Bipyridin-5-yl)]-alanine to Study the Structures of Proteins by Tabares, Leandro C., Daniel, Davis T., Vázquez-Ibar, José Luis, Kouklovsky, Cyrille, Alezra, Valérie, Un, Sun

“…Genetic code expansion allows modification of the physical and chemical properties of proteins by the site-directed insertion of noncanonical amino acids. Here…”
Get full text

Azurin and HS–: Towards Implementation of a Sensor for HS– Detection by Strianese, Maria, Palm, Gottfried J., Kohlhause, David, Ndamba, Lionel A., Tabares, Leandro C., Pellecchia, Claudio

“…Hydrogen sulfide (H2S) is an important biological messenger, which recently joined nitric oxide (NO) and carbon monoxide (CO) as an endogenously produced…”
Get full text

Pulse Electron Double Resonance Detected Multinuclear NMR Spectra of Distant and Low Sensitivity Nuclei and Its Application to the Structure of Mn(II) Centers in Organisms by Bruch, Eduardo M, Warner, Melissa T, Thomine, Sébastien, Tabares, Leandro C, Un, Sun

“…The ability to characterize the structure of metal centers beyond their primary ligands is important to understanding their chemistry. High-magnetic-field…”
Get full text

The Single Superoxide Dismutase of Rhodobacter capsulatus Is a Cambialistic, Manganese-Containing Enzyme by Tabares, Leandro C, Bittel, Cristian, Carrillo, Néstor, Bortolotti, Ana, Cortez, Néstor

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Conserved linker length in double dsRBD proteins from plants restricts interdomain motion by Mascali, Florencia C., Crespo, Roberta, Tabares, Leandro C., Rasia, Rodolfo M.

“…•dsRBDs are usually present in multiple copies in multidomain proteins.•The length of the linker connecting dsRBDs in plant proteins in highly conserved.•The…”
Get full text

Substitution of histidine 30 by asparagine in manganese superoxide dismutase alters biophysical properties and supports proliferation in a K562 leukemia cell line by Bonetta, Rosalin, Hunter, Gary J., Trinh, Chi H., Borowski, Tomasz, Fenech, Anthony G., Kulp, Maria, Tabares, Leandro C., Un, Sun, Hunter, Thérèse

“…We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-directed mutagenesis. The structure was solved at a resolution…”
Get full text

The oxidant-responsive diaphorase of Rhodobacter capsulatus is a ferredoxin (flavodoxin)-NADP(H) reductase by Bittel, Cristian, Tabares, Leandro C., Armesto, Martín, Carrillo, Néstor, Cortez, Néstor

“…Challenge of Rhodobacter capsulatus cells with the superoxide propagator methyl viologen resulted in the induction of a diaphorase activity identified as a…”
Get full text

The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins by Ching, H. Y. Vincent, Mascali, Florencia C, Bertrand, Hélène C, Bruch, Eduardo M, Demay-Drouhard, Paul, Rasia, Rodolfo M, Policar, Clotilde, Tabares, Leandro C, Un, Sun

“…A genetically encodable paramagnetic spin-label capable of self-assembly from naturally available components would offer a means for studying the in-cell…”
Get full text

Nanometric distance measurements between Mn(ii)DOTA centers by Vincent Ching, H Y, Demay-Drouhard, Paul, Bertrand, Hélène C, Policar, Clotilde, Tabares, Leandro C, Un, Sun

“…Pulse electron-electron double resonance (PELDOR) is a versatile technique for probing the structures and functions of complex biological systems. Despite the…”
Get more information

2-Deoxystreptamine Conjugates by Truncation-Derivatization of Neomycin by Aslam, M Waqar, Tabares, Leandro C, Andreoni, Alessio, Canters, Gerard W, Rutjes, Floris P J T, Van Delft, Floris L

“…A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose,…”
Get full text

Using Genetically Encodable Self-Assembling GdIII Spin Labels To Make In-Cell Nanometric Distance Measurements by Mascali, Florencia C., Ching, H. Y. Vincent, Rasia, Rodolfo M., Un, Sun, Tabares, Leandro C.

“…Double electron–electron resonance (DEER) can be used to study the structure of a protein in its native cellular environment. Until now, this has required…”
Get full text

Fluorescence Lifetime Analysis of Nitrite Reductase from Alcaligenes xylosoxidans at the Single-Molecule Level Reveals the Enzyme Mechanism by Tabares, Leandro C., Kostrz, Dorota, Elmalk, Abdalmohsen, Andreoni, Alessio, Dennison, Christopher, Aartsma, Thijs J., Canters, Gerard W.

“…Lighting the route: Immobilized, fluorescently labeled bacterial nitrite reductase (NiR) has been studied during steady‐state turnover by using single‐molecule…”
Get full text