Undifferentiated uterine carcinoma: Analysis of eighteen cases

Undifferentiated uterine carcinoma: Analysis of eighteen cases

Abstract Analysis of the surgicopathological characteristics and clinical follow-up of patients with undifferentiated uterine carcinoma (UUC) was conducted. A total of 18 cases operated between January 1993 and December 2013 were included. Among 1,690 patients with endometrial cancer, 18 patients (1...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology Vol. 35; no. 4; pp. 372 - 376
Main Authors: Üreyen, I., Ilgin, H., Turan, T., Ta çi, T., Karalök, A., Boran, N., Özfuttu, A., Tulunay, G.
Format: Journal Article
Language:English
Published: England Informa Healthcare 01-05-2015
Taylor & Francis
Taylor & Francis Ltd
Subjects:
Aged
Cancer surgery
Carcinoma - epidemiology
Carcinoma - pathology
Carcinoma - therapy
Chemoradiotherapy, Adjuvant - methods
Combined Modality Therapy - methods
Drug therapy
Endometrial cancer
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - pathology
Endometrial Neoplasms - therapy
Female
Follow-Up Studies
Gynecology
Humans
Hysterectomy - methods
Hysterectomy - statistics & numerical data
Lymph Node Excision - methods
Lymph Node Excision - statistics & numerical data
Lymph Nodes - pathology
Lymphatic Metastasis
Lymphatic system
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neoplasm Staging
surgicopathological factors
survival
Survival Analysis
Tumors
Turkey - epidemiology
undifferentiated tumour
Uterine cancer
Uterus - pathology
Endometrial cancer
undifferentiated tumour
survival
surgicopathological factors
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Summary:Abstract Analysis of the surgicopathological characteristics and clinical follow-up of patients with undifferentiated uterine carcinoma (UUC) was conducted. A total of 18 cases operated between January 1993 and December 2013 were included. Among 1,690 patients with endometrial cancer, 18 patients (1.1%) had UUC. Lymph node involvement was detected in 70.6%; depth of myometrial invasion was ≥ 0.5 in 55.6%; lymphovascular space invasion was detected in 99.3%; cervical stromal invasion was positive in 27.8%; omental and adnexal involvement were detected in 11.8% and 38.9%, respectively. The median follow-up time of the 12 patients evaluated in the survival analysis was 66 months. In the follow-up period, recurrence or progression during adjuvant therapy were observed in four patients (33.3%) and two patients (16.6%) died of the disease. UUC manifests as an aggressive tumour. In conclusion, a high rate of survival could be achieved with complete staging surgery, including an extensive lymphadenectomy with the contribution of adjuvant therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0144-3615
1364-6893
DOI:10.3109/01443615.2014.958441