Prevalence, distribution, and prognostic significance of morphological variants of neuroendocrine tumors of the gastrointestinal tract - a multicenter study

Prevalence, distribution, and prognostic significance of morphological variants of neuroendocrine tumors of the gastrointestinal tract - a multicenter study

The incidence and prevalence of neuroendocrine neoplasms (NENs) in many organs are increasing. Although such NENs have similar grades, they may exhibit quite different behaviors. In this multicenter study, we aimed to investigate the prevalence and distribution of different morphological NEN variant...

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Bibliographic Details
Published in:Polish journal of pathology Vol. 75; no. 2; pp. 126 - 137
Main Authors: Akay, Ebru, Ordu, Melike, Çoban, Ganime, Darakcı, Seher, Topaloğlu, Nahit, Taştekin, Filiz Meral, Ekinci, Büşra, Şahin, Nurhan, Gucin, Zuhal, Karaman, Hatice
Format: Journal Article
Language:English
Published: Poland Termedia Publishing House 01-01-2024
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Female
Gastrointestinal Neoplasms - epidemiology
Gastrointestinal Neoplasms - pathology
gastrointestinal tract
Humans
Male
Middle Aged
morphologic variants
neuroendocrine tumor
Neuroendocrine Tumors - epidemiology
Neuroendocrine Tumors - pathology
Prevalence
Prognosis
Young Adult
morphologic variants
neuroendocrine tumor
gastrointestinal tract
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Summary:The incidence and prevalence of neuroendocrine neoplasms (NENs) in many organs are increasing. Although such NENs have similar grades, they may exhibit quite different behaviors. In this multicenter study, we aimed to investigate the prevalence and distribution of different morphological NEN variants in the non-pancreatic gastrointestinal (GI) tract and determine whether they can guide prognosis prediction. Two hundred and fifty-six patients diagnosed with NENs originating from the GI tract from 7 different centers were included in the study. In 89 (36.6%) cases, different morphological variants were detected. When the variants were grouped according to their aggressiveness as described in the literature, a statistically significant relationship between aggressiveness and the variables organ and age was found ( p < 0.05). The oncocytic variant was found to metastasize more than the other aggressive types (42.9%). The paraganglioma-like variant was found to have a smaller size, lower proliferation index, and a more benign clinical course. This study demonstrated that well-differentiated GI neuroendocrine tumors (GI-NETs) have considerable morphological diversity. Generally, case reports of rare morphological variants of GI-NETs are available in the literature. We believe that our study contributes to a better understanding of the prevalence, localization, and significance of morphological variations in GI-NETs.
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ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2024.141014