Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma

Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma

It is now clear that angiogenesis and angiogenesis factors are important in the pathogenesis of haematological malignancies. High pretreatment levels of serum basic fibroblast growth factor have been shown to be associated with poor prognosis in patients with non-Hodgkin's lymphoma. The aim of...

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Bibliographic Details
Published in:British journal of cancer Vol. 86; no. 11; pp. 1770 - 1775
Main Authors: PAZGAL, I, ZIMRA, Y, TZABAR, C, OKON, E, RABIZADEH, E, SHAKLAI, M, BAIREY, O
Format: Journal Article
Language:English
Published: Basingstoke Nature Publishing Group 05-06-2002
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis
Biological and medical sciences
Cancer research
Disease Progression
Factor VIII - analysis
Female
Fibroblast Growth Factor 2 - analysis
Fibroblasts
Growth factors
Hematologic and hematopoietic diseases
Hematology
Humans
Kinases
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma
Lymphoma, Non-Hodgkin - mortality
Lymphoma, Non-Hodgkin - pathology
Male
Medical prognosis
Medical research
Medical sciences
Middle Aged
Molecular and Cellular Pathology
Neovascularization, Pathologic - pathology
Patients
Prognosis
Survival Analysis
Survival Rate
Treatment Outcome
Tumors
Tel Aviv Israel
Israel
Human
Immunohistochemistry
Prognosis
Angiogenic factor
Cytokine
Malignant hemopathy
Basic fibroblast growth factor
Non Hodgkin lymphoma
Density
Pathology
Angiogenesis
Microcirculation
Growth factor receptor
Polypeptide
Lymphoproliferative syndrome
Neovascularization
Growth factor
Biological receptor
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Summary:It is now clear that angiogenesis and angiogenesis factors are important in the pathogenesis of haematological malignancies. High pretreatment levels of serum basic fibroblast growth factor have been shown to be associated with poor prognosis in patients with non-Hodgkin's lymphoma. The aim of this study was to evaluate whether non-Hodgkin's lymphoma cells express basic fibroblast growth factor and/or its receptor (fibroblast growth factor receptor-1) and whether basic fibroblast growth factor expression correlates with basic fibroblast growth factor serum levels, intratumoral microvessel density, and patient outcome. We measured basic fibroblast growth factor by enzyme-linked immunosorbent assay in sera taken from 58 patients with non-Hodgkin's lymphoma before treatment and in 19 of them also after treatment. Pathological specimens at diagnosis were evaluated by immunohistochemistry staining using polyoclonal antibody against factor-VIII-related antigen, basic fibroblast growth factor and fibroblast growth factor receptor-1 to determine the expression of the microvessel count and basic fibroblast growth factor and fibroblast growth factor receptor-1. The lymphoma specimens demonstrated positive staining for basic fibroblast growth factor (in 23%) and fibroblast growth factor receptor-1 (in 58.5%). The patients who expressed basic fibroblast growth factor had a significantly worse progression-free and overall survival than those who did not (P=0.003 and P=0.03 respectively), while patients expressing fibroblast growth factor receptor-1 were less likely to achieve complete remission than those lacking the receptor (33% vs 65%, P=0.047). There was no correlation of basic fibroblast growth factor staining with either serum basic fibroblast growth factor levels or microvessel count. Basic fibroblast growth factor serum levels did not change significantly after treatment These results suggest that non-Hodgkin's lymphoma specimens express basic fibroblast growth factor and its receptor (fibroblast growth factor receptor-1) and this expression is associated with poor patient outcome.
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ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600330