Search Results - "TYSON, Charles A"

Bioactivation of Tegafur to 5-Fluorouracil Is Catalyzed by Cytochrome P-450 2A6 in Human Liver Microsomes in Vitro by IKEDA, Kazumasa, YOSHISUE, Kunihiro, MATSUSHIMA, Eiji, NAGAYAMA, Sekio, KOBAYASHI, Kaoru, TYSON, Charles A, CHIBA, Kan, KAWAGUCHI, Yasuro

“…Tegafur is a prodrug of 5-fluorouracil (5-FU) consisting of a new class of oral chemotherapeutic agents, tegafur/uracil and S-1, which are classified as…”
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The Potential for an Interaction between MRP2 (ABCC2) and Various Therapeutic Agents: Probenecid as a Candidate Inhibitor of the Biliary Excretion of Irinotecan Metabolites by Horikawa, Masato, Kato, Yukio, Tyson, Charles A., Sugiyama, Yuichi

“…Irinotecan hydrochloride (CPT-11) is an anticancer agent with unpredictable bouts of diarrhea as a dose-limiting toxic side-effect. Since the biliary excretion…”
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Potential Cholestatic Activity of Various Therapeutic Agents Assessed by Bile Canalicular Membrane Vesicles Isolated from Rats and Humans by Horikawa, Masato, Kato, Yukio, Tyson, Charles A., Sugiyama, Yuichi

“…The active transport of solutes mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance associated protein-2 (MRP2/ABCC2) are thought to…”
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In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans by Hirota, Noriko, Ito, Kiyomi, Iwatsubo, Takafumi, Green, Carol E., Tyson, Charles A., Shimada, Noriaki, Suzuki, Hiroshi, Sugiyama, Yuichi

“…We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants…”
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cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) by Kiuchi, Yuichi, Suzuki, Hiroshi, Hirohashi, Tomoko, Tyson, Charles A, Sugiyama, Yuichi

“…Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol…”
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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data by Iwatsubo, Takafumi, Hirota, Noriko, Ooie, Tsuyoshi, Suzuki, Hiroshi, Shimada, Noriaki, Chiba, Kan, Ishizaki, Takashi, Green, Carol E., Tyson, Charles A., Sugiyama, Yuichi

“…As a new approach to predicting in vivo drug metabolism in humans, scaling of in vivo metabolic clearance from in vitro data obtained using human liver…”
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Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4 by KANAMITSU, S.-I, ITO, K, GREEN, C. E, TYSON, C. A, SHIMADA, N, SUGIYAMA, Y

“…To quantitatively predict the in vivo interaction between triazolam and erythromycin, which involves mechanism-based inhibition of CYP3A4, from in vitro…”
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In vitro human tissue models in risk assessment : Report of a consensus-building workshop by MACGREGOR, James T, COLLINS, Jerry M, KEDDERIS, Gregory L, KRISHNAN, Kannan, LI, Albert P, PARCHMENT, Ralph E, THUMMEL, Kenneth, TOMASZEWSKI, Joseph E, ULRICH, Roger, VICKERS, Alison E. M, WRIGHTON, Steven A, SUGIYAMA, Yuichi, TYSON, Charles A, DEAN, Jack, SMITH, Lewis, ANDERSEN, Melvin, CURREN, Rodger D, HOUSTON, J. Brian, KADLUBAR, Fred F

“…Advances in the technology of human cell and tissue culture and the increasing availability of human tissue for laboratory studies have led to the increased…”
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Biliary excretion mechanism of CPT-11 and its metabolites in humans : Involvement of primary active transporters by CHU, X.-Y, KATO, Y, SUGIYAMA, Y, UEDA, K, SUZUKI, H, NIINUMA, K, TYSON, C. A, WEIZER, V, DABBS, J. E, FROEHLICH, R, GREEN, C. E

“…After administration of CTP-11, a camptothecin derivative exhibiting a wide spectrum of antitumor activity, dose-limiting gastrointestinal toxicity with great…”
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Extended rat liver slice survival and stability monitored using clinical biomarkers by Behrsing, Holger P, Vickers, Alison E.M, Tyson, Charles A

“…Precision-cut liver slices are reportedly limited as toxicity models by their short half-life in culture. We used traditional clinical chemistry biomarkers and…”
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Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans by Kitamura, S, Sugihara, K, Nakatani, K, Ohta, S, Ohhara, T, Ninomiya, S, Green, C E, Tyson, C A

“…This study deals with individual and species variations in the converting activity of methotrexate (MTX) to 7-hydroxymethotrexate in animals and humans. When…”
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Variation of Hepatic Methotrexate 7‐Hydroxylase Activity in Animals and Humans by Kitamura, Shigeyuki, Sugihara, Kazumi, Nakatani, Keiko, Ohta, Shigeru, Oh‐Hara, Toshinari, Ninomiya, Shin‐Ichi, Green, Carol E., Tyson, Charles A.

“…This study deals with individual and species variations in the converting activity of methotrexate (MTX) to 7‐hydroxymethotrexate in animals and humans. When…”
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Prediction of in Vivo Drug-Drug Interactions between Tolbutamide and Various Sulfonamides in Humans Based on in Vitro Experiments by KOMATSU, K, ITO, K, NAKAJIMA, Y, KANAMITSU, S.-I, IMAOKA, S, FUNAE, Y, GREEN, C. E, TYSON, C. A, SHIMADA, N, SUGIYAMA, Y

“…Drug-drug interactions between tolbutamide and sulfonamides have extensively been reported. We attempted to predict the in vivo interaction between tolbutamide…”
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Primary active transport of organic anions on bile canalicular membrane in humans by Niinuma, K, Kato, Y, Suzuki, H, Tyson, C A, Weizer, V, Dabbs, J E, Froehlich, R, Green, C E, Sugiyama, Y

“…Biliary excretion of several anionic compounds was examined by assessing their ATP-dependent uptake in bile canalicular membrane vesicles (CMV) prepared from…”
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Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes by Iwatsubo, T, Suzuki, H, Shimada, N, Chiba, K, Ishizaki, T, Green, C E, Tyson, C A, Yokoi, T, Kamataki, T, Sugiyama, Y

“…The metabolic rate of (S)-(-)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro [4,5] decane-L-tartarate monohydrate (YM796), an antidementia agent, was determined by…”
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Synergistic Bone Marrow Toxicity of Pyrimethamine and Zidovudine in Murine in Vivo and in Vitro Models: Mechanism of Toxicity by Freund, Yvonne R., Dabbs, Jack, Creek, Moire R., Phillips, Sandra J., Tyson, Charles A., MacGregor, James T.

“…Pyrimethamine (Pyr) is commonly used for treatment of toxoplasmic encephalitis in AIDS patients; however, in two clinical studies, an increased number of…”
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Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome by MIRSALIS, Jon C, SCHINDLER-HORVAT, Janice, HILL, James R, GREEN, Carol E, MITOMA, Chozo, TOMASZEWSKI, Joseph E, TYSON, Charles A, DONOHUE, Susan J

“…Quinocarmycin analog DX-52-1 is a cyanated derivative of quinocarmycin, a compound isolated from cultures of Streptomyces melanovinaceus. DX-52-1 was selected…”
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cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) 1 by Kiuchi, Yuichi, Suzuki, Hiroshi, Hirohashi, Tomoko, Tyson, Charles A, Sugiyama, Yuichi

“…Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol…”
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Kinetics and mechanism of the metal chelate catalyzed oxidation of pyrocatechols by Tyson, Charles A, Martell, Arthur E

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Kinetic studies on the autoxidation of 3,5-di-tert-butylpyrocatechol by Tyson, Charles A, Martell, Arthur E

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