Search Results - "TYRER, Jonathan"

Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2 by Tyrer, Jonathan P, Peng, Pei-Chen, DeVries, Amber A, Gayther, Simon A, Jones, Michelle R, Pharoah, Paul D

“…As precision medicine advances, polygenic scores (PGS) have become increasingly important for clinical risk assessment. Many methods have been developed to…”
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A breast cancer prediction model incorporating familial and personal risk factors by Tyrer, Jonathan, Duffy, Stephen W., Cuzick, Jack

“…An Erratum has been published for this article in Statistics in Medicine 2005; 24(1):156. Please note that the corresponding author's e‐mail address has now…”
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Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk by Wilcox, Naomi, Dumont, Martine, González-Neira, Anna, Carvalho, Sara, Joly Beauparlant, Charles, Crotti, Marco, Luccarini, Craig, Soucy, Penny, Dubois, Stéphane, Nuñez-Torres, Rocio, Pita, Guillermo, Gardner, Eugene J., Dennis, Joe, Alonso, M. Rosario, Álvarez, Nuria, Baynes, Caroline, Collin-Deschesnes, Annie Claude, Desjardins, Sylvie, Becher, Heiko, Behrens, Sabine, Bolla, Manjeet K., Castelao, Jose E., Chang-Claude, Jenny, Cornelissen, Sten, Dörk, Thilo, Engel, Christoph, Gago-Dominguez, Manuela, Guénel, Pascal, Hadjisavvas, Andreas, Hahnen, Eric, Hartman, Mikael, Herráez, Belén, Jung, Audrey, Keeman, Renske, Kiechle, Marion, Li, Jingmei, Loizidou, Maria A., Lush, Michael, Michailidou, Kyriaki, Panayiotidis, Mihalis I., Sim, Xueling, Teo, Soo Hwang, Tyrer, Jonathan P., van der Kolk, Lizet E., Wahlström, Cecilia, Wang, Qin, Perry, John R. B., Benitez, Javier, Schmidt, Marjanka K., Schmutzler, Rita K., Pharoah, Paul D. P., Droit, Arnaud, Dunning, Alison M., Kvist, Anders, Devilee, Peter, Easton, Douglas F., Simard, Jacques

“…Linkage and candidate gene studies have identified several breast cancer susceptibility genes, but the overall contribution of coding variation to breast…”
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Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case-Control Study from the Ovarian Cancer Association Consortium by Gersekowski, Kate, Ibiebele, Torukiri I, Doherty, Jennifer A, Harris, Holly R, Goodman, Marc T, Terry, Kathryn L, Wu, Anna H, Bandera, Elisa V, Qin, Bo, Ong, Jue-Sheng, Tyrer, Jonathan P, Dixon-Suen, Suzanne C, Modugno, Francesmary, Risch, Harvey A, Webb, Penelope M

“…Although folate intake has not been associated with an increased risk of ovarian cancer overall, studies of other cancer types have suggested that high folate…”
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Tunnelling with Full-Face Shielded Machines: A 3D Numerical Analysis of an Earth Pressure Balance (EPB) Excavation Sequence Using the Finite Element Method (FEM) by Tyrer, Jonathan, Paraskevopoulou, Chrysothemis, Shah, Ravi, Miller, Richard, Kavvadas, Michael

“…Urban tunnelling can be highly challenging, especially in areas where limited ground settlements and environmental disturbance is required. Mechanised…”
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The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population by Song, Honglin, Cicek, Mine S, Dicks, Ed, Harrington, Patricia, Ramus, Susan J, Cunningham, Julie M, Fridley, Brooke L, Tyrer, Jonathan P, Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A, Goode, Ellen L, Pharoah, Paul D P

“…The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian…”
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A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk by Pooley, Karen A, Bojesen, Stig E, Weischer, Maren, Nielsen, Sune F, Thompson, Deborah, Amin Al Olama, Ali, Michailidou, Kyriaki, Tyrer, Jonathan P, Benlloch, Sara, Brown, Judith, Audley, Tina, Luben, Robert, Khaw, K-T, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Kote-Jarai, Zsofia, Baynes, Caroline, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dicks, Ed, Yang, Rongxi, Rudolph, Anja, Schildkraut, Joellen, Chang-Claude, Jenny, Burwinkel, Barbara, Chenevix-Trench, Georgia, Pharoah, Paul D P, Berchuck, Andrew, Eeles, Rosalind A, Easton, Douglas F, Dunning, Alison M, Nordestgaard, Børge G

“…Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a…”
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Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study by Liou, Lathan, Kaptoge, Stephen, Dennis, Joe, Shah, Mitul, Tyrer, Jonathan, Inouye, Michael, Easton, Douglas F, Pharoah, Paul D P

“…Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing…”
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Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study by Barnett, Gillian C, Dr, Coles, Charlotte E, PhD, Elliott, Rebecca M, MRes, Baynes, Caroline, Luccarini, Craig, BSc, Conroy, Don, Wilkinson, Jennifer S, BSc, Tyrer, Jonathan, PhD, Misra, Vivek, MB BS, Platte, Radka, BSc, Gulliford, Sarah L, PhD, Sydes, Matthew R, MSc, Hall, Emma, PhD, Bentzen, Søren M, Prof, Dearnaley, David P, Prof, Burnet, Neil G, PhD, Pharoah, Paul DP, PhD, Dunning, Alison M, PhD, West, Catharine ML, Prof

“…Summary Background Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few…”
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Telomere length in prospective and retrospective cancer case-control studies by Pooley, Karen A, Sandhu, Manjinder S, Tyrer, Jonathan, Shah, Mitul, Driver, Kristy E, Luben, Robert N, Bingham, Sheila A, Ponder, Bruce A J, Pharoah, Paul D P, Khaw, Kay-Tee, Easton, Douglas F, Dunning, Alison M

“…Previous studies have reported that shorter mean telomere length in lymphocytes was associated with increased susceptibility to common diseases of aging, and…”
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The admixture maximum likelihood test to test for association between rare variants and disease phenotypes by Tyrer, Jonathan P, Guo, Qi, Easton, Douglas F, Pharoah, Paul D P

“…The development of genotyping arrays containing hundreds of thousands of rare variants across the genome and advances in high-throughput sequencing…”
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Evidence of a genetic link between endometriosis and ovarian cancer by Lee, Alice W., M.P.H, Templeman, Claire, M.D, Stram, Douglas A., B.S, Beesley, Jonathan, Ph.D, Tyrer, Jonathan, Ph.D, Berchuck, Andrew, M.D, Pharoah, Paul P., Ph.D, Chenevix-Trench, Georgia, Ph.D, Pearce, Celeste Leigh, Ph.D

“…Objective To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. Design Pooled genetic analysis. Setting University…”
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Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence by Liu, Gang, Mukherjee, Bhramar, Lee, Seunggeun, Lee, Alice W, Wu, Anna H, Bandera, Elisa V, Jensen, Allan, Rossing, Mary Anne, Moysich, Kirsten B, Chang-Claude, Jenny, Doherty, Jennifer A, Gentry-Maharaj, Aleksandra, Kiemeney, Lambertus, Gayther, Simon A, Modugno, Francesmary, Massuger, Leon, Goode, Ellen L, Fridley, Brooke L, Terry, Kathryn L, Cramer, Daniel W, Ramus, Susan J, Anton-Culver, Hoda, Ziogas, Argyrios, Tyrer, Jonathan P, Schildkraut, Joellen M, Kjaer, Susanne K, Webb, Penelope M, Ness, Roberta B, Menon, Usha, Berchuck, Andrew, Pharoah, Paul D, Risch, Harvey, Pearce, Celeste Leigh

“…Abstract There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a…”
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FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation by Udler, Miriam S., Meyer, Kerstin B., Pooley, Karen A., Karlins, Eric, Struewing, Jeffery P., Zhang, Jinghui, Doody, David R., MacArthur, Stewart, Tyrer, Jonathan, Pharoah, Paul D., Luben, Robert, Bernstein, Leslie, Kolonel, Laurence N., Henderson, Brian E., Le Marchand, Loic, Ursin, Giske, Press, Michael F., Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Ponder, Bruce A.J., Haiman, Christopher A., Malone, Kathleen E., Dunning, Alison M., Ostrander, Elaine A., Easton, Douglas F.

“…Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent, but a causative…”
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Evaluating the power to discriminate between highly correlated SNPs in genetic association studies by Udler, Miriam S., Tyrer, Jonathan, Easton, Douglas F.

“…Neighboring common polymorphisms are often correlated (in linkage disequilibrium (LD)) as a result of shared ancestry. An association between a polymorphism…”
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Association between common variation in 120 candidate genes and breast cancer risk by Pharoah, Paul D P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A J

“…Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have…”
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Common Polymorphisms in the Prostaglandin Pathway Genes and Their Association with Breast Cancer Susceptibility and Survival by ABRAHAM, Jean E, HARRINGTON, Patricia, DRIVER, Kristy E, TYRER, Jonathan, EASTON, Douglas F, DUNNING, Alison M, PHAROAH, Paul D. P

“…Purpose: There is evidence that genetic variation in the prostaglandin pathway affects cancer susceptibility and progression. Conflicting data from several…”
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Estimating the effect of treatment in a proportional hazards model in the presence of non-compliance and contamination by Cuzick, Jack, Sasieni, Peter, Myles, Jonathan, Tyrer, Jonathan

“…Methods for adjusting for non-compliance and contamination, which respect the randomization, are extended from binary outcomes to time-to-event analyses by…”
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ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium by Poole, Elizabeth M., Gates, Margaret A., High, Brigit A., Chanock, Stephen J., Cramer, Daniel W., Cunningham, Julie M., Fridley, Brooke L., Gayther, Simon A., Goode, Ellen L., Iversen, Edwin S., Lissowska, Jolanta, Weber, Rachel T. Palmieri, Pharoah, Paul D. P., Phelan, Catherine M., Ramus, Susan J., Schildkraut, Joellen M., Sutphen, Rebecca, Tsai, Ya-Yu, Tyrer, Jonathan, Vierkant, Robert A., Wentzensen, Nicolas, Yang, Hannah P., Terry, Kathryn L., Tworoger, Shelley S.

“…Purpose: Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods: In eight studies…”
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Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population by Driver, Kristy E., Song, Honglin, Lesueur, Fabienne, Ahmed, Shahana, Barbosa-Morais, Nuno L., Tyrer, Jonathan P., Ponder, Bruce A.J., Easton, Douglas F., Pharoah, Paul D.P., Dunning, Alison M.

“…Using a large-scale case–control study, we examined whether common single-nucleotide polymorphisms (SNPs) within 13 genes involved in the cell cycle pathway…”
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