Search Results - "TYLER, Douglas S"

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy by Holtzhausen, Alisha, Zhao, Fei, Evans, Kathy S, Tsutsui, Masahito, Orabona, Ciriana, Tyler, Douglas S, Hanks, Brent A

“…The β-catenin signaling pathway has been demonstrated to promote the development of a tolerogenic dendritic cell (DC) population capable of driving regulatory…”
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It depends on your perspective: Resident satisfaction with operative experience by Perone, Jennifer. A, Fankhauser, Grant. T, Adhikari, Deepak, Mehta, Hemalkumar B, Woods, Majka B, Tyler, Douglas. S, Brown, Kimberly M

“…Abstract Introduction Resident satisfaction is a key performance metric for surgery programs; we studied factors influencing resident satisfaction in operative…”
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The Impact of Vascular Resection on Early Postoperative Outcomes after Pancreaticoduodenectomy: An Analysis of the American College of Surgeons National Surgical Quality Improvement Program Database by Castleberry, Anthony W., White, Rebekah R., De La Fuente, Sebastian G., Clary, Bryan M., Blazer, Dan G., McCann, Richard L., Pappas, Theodore N., Tyler, Douglas S., Scarborough, John E.

“…Background Several single-center reports suggest that vascular resection (VR) during pancreaticoduodenectomy (PD) for patients with pancreatic adenocarcinoma…”
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Management of 1- to 2-cm Carcinoid Tumors of the Appendix: Using the National Cancer Data Base to Address Controversies in General Surgery by Nussbaum, Daniel P., MD, Speicher, Paul J., MD, Gulack, Brian C., MD, Keenan, Jeffrey E., MD, Ganapathi, Asvin M., MD, Englum, Brian R., MD, Tyler, Douglas S., MD, Blazer, Dan G., MD

“…Background The management of 1- to 2-cm appendiceal carcinoid tumors remains controversial. Here we use the National Cancer Data Base (NCDB) to compare…”
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Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model by Gorgun, Falih M., Widen, Steven G., Tyler, Douglas S., Englander, Ella W.

“…Sequencing data from different types of cancers including melanomas demonstrate that tumors with high mutational loads are more likely to respond to immune…”
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Concurrent Chemoradiotherapy in Resected Extrahepatic Cholangiocarcinoma by Nelson, John W., M.D, Ghafoori, A. Paiman, M.D, Willett, Christopher G., M.D, Tyler, Douglas S., M.D, Pappas, Theodore N., M.D, Clary, Bryan M., M.D, Hurwitz, Herbert I., M.D, Bendell, Johanna C., M.D, Morse, Michael A., M.D, Clough, Robert W., B.A, Czito, Brian G., M.D

“…Purpose Extrahepatic cholangiocarcinoma is a rare malignancy. Despite radical resection, survival remains poor, with high rates of local and distant failure…”
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Intraoperative Radiation Therapy by WILLETT, Christopher G, CZITO, Brian G, TYLER, Douglas S

“…Intraoperative radiation therapy (IORT) is the delivery of irradiation at the time of an operation. This is performed by different techniques including…”
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Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis by Therien, Aaron D, Beasley, Georgia M, Rhodin, Kristen E, Farrow, Norma E, Tyler, Douglas S, Boczkowski, David, Al-Rohil, Rami N, Holl, Eda K, Nair, Smita K

“…B cells are key regulators of immune responses in melanoma. We aimed to explore differences in the histologic location and activation status of B cell…”
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Prospective Multicenter Phase II Trial of Systemic ADH-1 in Combination With Melphalan via Isolated Limb Infusion in Patients With Advanced Extremity Melanoma by BEASLEY, Georgia M, RIBOH, Jonathan C, AUGUSTINE, Christina K, ZAGER, Jonathan S, HOCHWALD, Steven N, GROBMYER, Stephen R, PETERSON, Bercedis, ROYAL, Richard, ROSS, Merrick I, TYLER, Douglas S

“…Isolated limb infusion (ILI) with melphalan (M-ILI) dosing corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit…”
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Current Trends in Regional Therapy for Melanoma: Lessons Learned from 225 Regional Chemotherapy Treatments between 1995 and 2010 at a Single Institution by Raymond, Amanda K., BS, Beasley, Georgia M., MD, Broadwater, Gloria, MS, Augustine, Christina K., PhD, Padussis, James C., MD, Turley, Ryan, MD, Peterson, Bercedis, PhD, Seigler, Hilliard, MD, FACS, Pruitt, Scott K., MD, PhD, FACS, Tyler, Douglas S., MD, FACS

“…Background Hyperthermic isolated limb perfusion (HILP) and isolated limb infusion (ILI) are used to manage advanced extremity melanoma, but no consensus exists…”
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Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma by Augustine, Christina K, Yoo, Jin Soo, Potti, Anil, Yoshimoto, Yasunori, Zipfel, Patricia A, Friedman, Henry S, Nevins, Joseph R, Ali-Osman, Francis, Tyler, Douglas S

“…Purpose: Despite objective response rates of only ∼13%, temozolomide remains one of the most effective single chemotherapy agents against metastatic melanoma,…”
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Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift by Zhuo, Ming, Gorgun, Falih M., Tyler, Douglas S., Englander, Ella W.

“…The hypoxic environment within solid tumors impedes the efficacy of chemotherapeutic treatments. Here, we demonstrate that hypoxia augments the capacity of…”
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Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment by Augustine, Christina K, Yoshimoto, Yasunori, Gupta, Mukur, Zipfel, Patricia A, Selim, M Angelica, Febbo, Phillip, Pendergast, Ann Marie, Peters, William P, Tyler, Douglas S

“…Malignant transformation in melanoma is characterized by a phenotype "switch" from E- to N-cadherin, which is associated with increased motility and…”
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A standardized care plan is associated with shorter hospital length of stay in patients undergoing pancreaticoduodenectomy by Nussbaum, Daniel P., MD, Penne, Kara, MSN, Stinnett, Sandra S., MD, Speicher, Paul J., MD, Cocieru, Andrei, MD, Blazer, Dan G., MD, Zani, Sabino, MD, Clary, Bryan M., MD, Tyler, Douglas S., MD, White, Rebekah R., MD

“…Abstract Background In this retrospective review, we evaluate a standardized care plan (SCP) for patients undergoing pancreaticoduodenectomy, which included…”
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Efficacy of Repeat Sentinel Lymph Node Biopsy in Patients Who Develop Recurrent Melanoma by Beasley, Georgia M., MD, Speicher, Paul, MD, Sharma, Ketan, MD, Seigler, Hilliard, MD, FACS, Salama, April, MD, Mosca, Paul, MD, PhD, FACS, Tyler, Douglas S., MD, FACS

“…Background Even after negative sentinel lymph node biopsy (SLNB) for primary melanoma, patients who develop in-transit (IT) melanoma or local recurrences (LR)…”
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Gastric Neoplasms by Tyler, Douglas S., MD, Olino, Kelly, MD

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Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma by TURLEY, Ryan S, FONTANELLA, Andrew N, TYLER, Douglas S, PADUSSIS, James C, TOSHIMITSU, Hiroaki, TOKUHISA, Yoshihiro, CHO, Eugenia H, HANNA, Gabi, BEASLEY, Georgia M, AUGUSTINE, Christina K, DEWHIRST, Mark W

“…To investigate whether the systemically administered anti-VEGF monoclonal antibody bevacizumab could improve regional chemotherapy treatment of advanced…”
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A Multi-Institutional Experience of Isolated Limb Infusion: Defining Response and Toxicity in the US by Beasley, Georgia M., MD, Caudle, Abigail, MD, Petersen, Rebecca P., MD, BS, McMahon, Nicole S., BS, Padussis, James, MD, Mosca, Paul J., MD, PhD, FACS, Zager, Jonathan S., MD, FACS, Hochwald, Steven N., MD, FACS, Grobmyer, Stephen R., MD, FACS, Delman, Keith A., MD, Andtbacka, Robert H., MD, Noyes, R. Dirk, MD, FACS, Kane, John M., MD, FACS, Seigler, Hilliard, MD, Pruitt, Scott K., MD, PhD, FACS, Ross, Merrick I., MD, FACS, Tyler, Douglas S., MD, FACS

“…Background Isolated limb infusion (ILI) is a minimally invasive approach for treating in-transit extremity melanoma, with only two US single-center studies…”
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Improved survival with pulmonary metastasectomy: An analysis of 1720 patients with pulmonary metastatic melanoma by Petersen, Rebecca P., MD, MSc, Hanish, Steven I., MD, Haney, John C., MD, Miller, Charles C., PhD, Burfeind, William R., MD, Tyler, Douglas S., MD, Seigler, Hilliard F., MD, Wolfe, Walter, MD, D’Amico, Thomas A., MD, Harpole, David H., MD

“…Objectives The outcomes of patients with metastatic melanoma are poor. Although prognostic models have been developed to predict the occurrence of pulmonary…”
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Radiotherapy in the Treatment of Patients With Unresectable Extrahepatic Cholangiocarcinoma by Ghafoori, A. Paiman, M.D, Nelson, John W., M.D, Willett, Christopher G., M.D, Chino, Junzo, M.D, Tyler, Douglas S., M.D, Hurwitz, Herbert I., M.D, Uronis, Hope E., M.D, Morse, Michael A., M.D, Clough, Robert W., B.S, Czito, Brian G., M.D

“…Purpose Extrahepatic cholangiocarcinoma is an uncommon but lethal malignancy. We analyzed the role of definitive chemoradiotherapy for patients with…”
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