Search Results - "TYLER, Betty M"

Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology by Hersh, Andrew M, Alomari, Safwan, Tyler, Betty M

“…The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding most drugs from the brain. Treatment of brain tumors is limited by…”
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Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response by Sesen, Julie, Dahan, Perrine, Scotland, Sarah J, Saland, Estelle, Dang, Van-Thi, Lemarié, Anthony, Tyler, Betty M, Brem, Henry, Toulas, Christine, Cohen-Jonathan Moyal, Elizabeth, Sarry, Jean-Emmanuel, Skuli, Nicolas

“…High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining surgery, chemotherapy, mainly temozolomide, and radiotherapy. This…”
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A miniature multi-contrast microscope for functional imaging in freely behaving animals by Senarathna, Janaka, Yu, Hang, Deng, Callie, Zou, Alice L., Issa, John B., Hadjiabadi, Darian H., Gil, Stacy, Wang, Qihong, Tyler, Betty M., Thakor, Nitish V., Pathak, Arvind P.

“…Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, and dysregulated in neuropathologies such as brain…”
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Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches by Caraway, Chad A, Gaitsch, Hallie, Wicks, Elizabeth E, Kalluri, Anita, Kunadi, Navya, Tyler, Betty M

“…Translation of novel therapies for brain cancer into clinical practice is of the utmost importance as primary brain tumors are responsible for more than…”
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Metformin and Cancer, an Ambiguanidous Relationship by Skuli, Sarah J, Alomari, Safwan, Gaitsch, Hallie, Bakayoko, A'ishah, Skuli, Nicolas, Tyler, Betty M

“…The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs targeting cancer cell metabolism may have promising…”
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Long-Acting Opioid Analgesics for Acute Pain: Pharmacokinetic Evidence Reviewed by Tyler, Betty M, Guarnieri, Michael

“…Long-acting injectable (LAI) opioid formulations mitigate the harm profiles and management challenges associated with providing effective analgesia for…”
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Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies by Mangraviti, Antonella, Volpin, Francesco, Cha, Jaepyeong, Cunningham, Samantha I., Raje, Karan, Brooke, M. Jason, Brem, Henry, Olivi, Alessandro, Huang, Judy, Tyler, Betty M., Rege, Abhishek

“…Cerebrovascular surgery can benefit from an intraoperative system that conducts continuous monitoring of cerebral blood flow (CBF). Such a system must be…”
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Paclitaxel: a review of adverse toxicities and novel delivery strategies by Marupudi, Neena I, Han, James E, Li, Khan W, Renard, Violette M, Tyler, Betty M, Brem, Henry

“…Better known as Taxol (Bristol-Myers Squibb), paclitaxel is the first member of the taxane family to be used in cancer chemotherapy. The taxanes exert their…”
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Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma by Wicks, Robert T, Azadi, Javad, Mangraviti, Antonella, Zhang, Irma, Hwang, Lee, Joshi, Avadhut, Bow, Hansen, Hutt-Cabezas, Marianne, Martin, Kristin L, Rudek, Michelle A, Zhao, Ming, Brem, Henry, Tyler, Betty M

“…3-bromopyruvate (3-BrPA) and dichloroacetate (DCA) are inhibitors of cancer-cell specific aerobic glycolysis. Their application in glioma is limited by…”
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Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells by Gallia, Gary L, Tyler, Betty M, Hann, Christine L, Siu, I-Mei, Giranda, Vincent L, Vescovi, Angelo L, Brem, Henry, Riggins, Gregory J

“…A commonly activated signaling cascade in many human malignancies, including glioblastoma multiforme, is the Akt pathway. This pathway can be activated via…”
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Combination of Intracranial Temozolomide With Intracranial Carmustine Improves Survival When Compared With Either Treatment Alone in a Rodent Glioma Model by Recinos, Violette Renard, Tyler, Betty M., Bekelis, Kimon, Sunshine, Sarah Brem, Vellimana, Ananth, Li, Khan Wayne, Brem, Henry

“…Abstract BACKGROUND Local delivery of temozolomide (TMZ) through polymers is superior to oral administration in a rodent glioma model. OBJECTIVE We…”
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Preclinical efficacy of ribavirin in SHH and group 3 medulloblastoma by Huq, Sakibul, Kannapadi, Nivedha V, Casaos, Joshua, Lott, Tarik, Felder, Raphael, Serra, Riccardo, Gorelick, Noah L, Ruiz-Cardozo, Miguel A, Ding, Andy S, Cecia, Arba, Medikonda, Ravi, Ehresman, Jeff, Brem, Henry, Skuli, Nicolas, Tyler, Betty M

“…Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and group 3 (Myc driven) subtypes that are associated with the activity…”
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Multi-pulse drug delivery from a resorbable polymeric microchip device by Grayson, Amy C. Richards, Choi, Insung S., Tyler, Betty M., Wang, Paul P., Brem, Henry, Cima, Michael J., Langer, Robert

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Characterization of TEM1/endosialin in human and murine brain tumors by Carson-Walter, Eleanor B, Winans, Bethany N, Whiteman, Melissa C, Liu, Yang, Jarvela, Sally, Haapasalo, Hannu, Tyler, Betty M, Huso, David L, Johnson, Mahlon D, Walter, Kevin A

“…TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis. We characterized the expression pattern of TEM1/endosialin in astrocytic and…”
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Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas by Kim, Jennifer E, Patel, Mira A, Mangraviti, Antonella, Kim, Eileen S, Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric W, Tam, Ada, Xu, Haiying, Mathios, Dimitrios, Jackson, Christopher M, Harris-Bookman, Sarah, Garzon-Muvdi, Tomas, Sheu, Mary, Martin, Allison M, Tyler, Betty M, Tran, Phuoc T, Ye, Xiaobu, Olivi, Alessandro, Taube, Janis M, Burger, Peter C, Drake, Charles G, Brem, Henry, Pardoll, Drew M, Lim, Michael

“…Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the…”
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Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier by Hersh, Andrew M, Bhimreddy, Meghana, Weber-Levine, Carly, Jiang, Kelly, Alomari, Safwan, Theodore, Nicholas, Manbachi, Amir, Tyler, Betty M

“…Glioblastoma (GBM) is an aggressive primary astrocytoma associated with short overall survival. Treatment for GBM primarily consists of maximal safe surgical…”
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The toxicity of intrathecal bevacizumab in a rabbit model of leptomeningeal carcinomatosis by Brastianos, Priscilla K., Brastianos, Harry C., Hsu, Wesley, Sciubba, Daniel M., Kosztowski, Thomas, Tyler, Betty M., Recinos, Violette Renard, Burger, Peter, Grossman, Stuart A.

“…Leptomeningeal carcinomatosis (LC) is a devastating complication of cancer. Intrathecal administration of cytotoxic chemotherapy adds little to survival which…”
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Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy by Hersh, Andrew M, Gaitsch, Hallie, Alomari, Safwan, Lubelski, Daniel, Tyler, Betty M

“…Glioblastoma (GBM) is an aggressive tumor of the central nervous system categorized by the World Health Organization as a Grade 4 astrocytoma. Despite…”
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Polilactofate Microspheres for Paclitaxel Delivery to Central Nervous System Malignancies by LI, Khan W, WENBIN DANG, TYLER, Betty M, TROIANO, Greg, TIHAN, Tarik, BREM, Henry, WALTER, Kevin A

“…Purpose: The purpose of this study was to demonstrate that surgically implanted, controlled-release, biodegradable polilactofate microspheres (Paclimer) can be…”
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Dendrimer Technology in Glioma: Functional Design and Potential Applications by Gaitsch, Hallie, Hersh, Andrew M, Alomari, Safwan, Tyler, Betty M

“…Novel therapeutic and diagnostic methods are sorely needed for gliomas, which contribute yearly to hundreds of thousands of cancer deaths worldwide. Despite…”
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