Search Results - "TYKOCINSKI, Mark L"

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer by Greene, Mark I, Furuuchi, Keiji, Kojima, Yoshitsugu, Tone, Yukiko, Tone, Masahide, Tykocinski, Mark L

“…The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4 + CD25 + regulatory T (T reg ) cells. Details of the mechanism…”
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Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells by Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Tykocinski, Mark L., Nagajyothi, Fnu, Machado, Fabiana S., Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.

“…It is now widely recognized that the tumor microenvironment promotes cancer cell growth and metastasis via changes in cytokine secretion and extracellular…”
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Can Empathy, Other Personality Attributes, and Level of Positive Social Influence in Medical School Identify Potential Leaders in Medicine? by Hojat, Mohammadreza, Michalec, Barret, Veloski, J Jon, Tykocinski, Mark L

“…PURPOSETo test the hypotheses that medical students recognized by peers as the most positive social influencers would score (1) high on measures of engaging…”
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Virchow at 200 and Lown at 100 — Physicians as Activists by Mangione, Salvatore, Tykocinski, Mark L

“…The Covid-19 pandemic has forced many people to reconsider what medicine is all about. But debate over what doctoring is — and what it is not — is nothing new,…”
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Fn14•TRAIL effectively inhibits hepatocellular carcinoma growth by Aronin, Alexandra, Amsili, Shira, Prigozhina, Tatyana B, Tzdaka, Kobi, Rachmilewitz, Jacob, Shani, Noam, Tykocinski, Mark L, Dranitzki Elhalel, Michal

“…New strategies for the treatment of hepatocellular carcinoma (HCC) are needed, given that currently available chemotherapeutics are inefficient. Since tumor…”
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Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14 by Ochanuna, Zohar, Geiger-Maor, Anat, Dembinsky-Vaknin, Adi, Karussis, Dimitrios, Tykocinski, Mark L, Rachmilewitz, Jacob

“…T-helper polarization of naïve T cells is determined by a complex mechanism that involves many factors, eventually leading to activation of Th1, Th2, or Th17…”
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Academic Pathology's “Spiderless Network”: The power of a professional society, its listserv, and its journal during a public health emergency by Tykocinski, Mark L.

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Negative Regulation of T Cell Activation by Placental Protein 14 Is Mediated by the Tyrosine Phosphatase Receptor CD45 by Rachmilewitz, Jacob, Borovsky, Zipora, Riely, Gregory J., Miller, Robin, Tykocinski, Mark L.

“…CD45 is the major protein tyrosine phosphatase receptor on T cell surfaces that functions as both a positive and a negative regulator of T cell receptor (TCR)…”
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HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells by Romeo, Carmella, Weber, Matthew C, Zarei, Mahsa, DeCicco, Danielle, Chand, Saswati N, Lobo, Angie D, Winter, Jordan M, Sawicki, Janet A, Sachs, Jonathan N, Meisner-Kober, Nicole, Yeo, Charles J, Vadigepalli, Rajanikanth, Tykocinski, Mark L, Brody, Jonathan R

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL…”
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Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL by Makdasi, Efi, Amsili, Shira, Aronin, Alexandra, Prigozhina, Tatyana B, Tzdaka, Kobi, Gozlan, Yosi Meir, Ben Gigi-Tamir, Liat, Sagiv, Jitka Yehudith, Shkedy, Fanny, Shani, Noam, Tykocinski, Mark L, Dranitzki Elhalel, Michal

“…Cytotoxic T-lymphocyte antigen 4 (CTLA4)-FasL, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells of the…”
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Identifying potential engaging leaders within medical education: The role of positive influence on peers by Michalec, Barret, Veloski, J. Jon, Hojat, Mohammadreza, Tykocinski, Mark L.

“…Background: Previous research has paid little to no attention towards exploring methods of identifying existing medical student leaders. Aim: Focusing on the…”
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CTLA-4·Ig converts naive CD4+CD25− T cells into CD4+CD25+ regulatory T cells by Razmara, Marjaneh, Hilliard, Brendan, Ziarani, Azadeh K., Chen, Youhai H., Tykocinski, Mark L.

“…CTLA-4·Ig was originally designed as an immunosuppressive agent capable of interfering with the co-stimulation of T cells. In the present study, we demonstrate…”
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CTLA-4–Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells by Huang, Jui-Han, Tykocinski, Mark L.

“…Co-stimulator blockade and trans inhibitory signaling, using agents such as CTLA-4–Ig and Fas ligand (FasL) respectively have been invoked as alternative…”
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CD40·FasL and CTLA-4·FasL Fusion Proteins Induce Apoptosis in Malignant Cell Lines by Dual Signaling by Orbach, Ariel, Rachmilewitz, Jacob, Shani, Noam, Isenberg, Yonatan, Parnas, Miriam, Huang, Jui-Han, Tykocinski, Mark L, Dranitzki-Elhalel, Michal

“…Evolution of apoptosis resistance in both lymphoma and leukemia cells is well documented, and induction of apoptosis in malignant cells is a major goal of…”
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OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites by Tone, Yukiko, Kojima, Yoshitsugu, Furuuchi, Keiji, Brady, Maya, Yashiro-Ohtani, Yumi, Tykocinski, Mark L, Tone, Masahide

“…OX40 is a member of the TNFR superfamily (CD134; TNFRSF4) that is expressed on activated T cells and regulates T cell-mediated immune responses. In this study,…”
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CTLA-4 {middle dot} FasL Induces Early Apoptosis of Activated T Cells by Interfering with Anti-Apoptotic Signals by Orbach, Ariel, Rachmilewitz, Jacob, Parnas, Miram, Huang, Jui-Han, Tykocinski, Mark L, Dranitzki-Elhalel, Michael

“…The fusion protein CTLA-4 . FasL, a paradigmatic "trans signal converter protein", can attach to APC surfaces and in effect convert B7-activating costimulator…”
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Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation by Moody, D. Branch, Briken, Volker, Cheng, Tan-Yun, Roura-Mir, Carme, Guy, Mark R, Geho, David H, Tykocinski, Mark L, Besra, Gurdyal S, Porcelli, Steven A

“…CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses…”
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Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis by Razmara, Marjaneh, Hilliard, Brendan, Ziarani, Azadeh K, Murali, Ramachandran, Yellayi, Srikanth, Ghazanfar, Mustafa, Chen, Youhai H, Tykocinski, Mark L

“…Hallmarks of the pathogenesis of autoimmune encephalomyelitis include perivascular infiltration of inflammatory cells into the central nervous system,…”
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Differential Regulation of Th1/Th2 Cytokine Responses by Placental Protein 14 by Mishan-Eisenberg, Galit, Borovsky, Zipora, Weber, Matthew C, Gazit, Roi, Tykocinski, Mark L, Rachmilewitz, Jacob

“…The potency of TCR signaling during primary CD4+ T cell activation influences initial cytokine expression patterns and subsequent polarization toward either…”
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CTLA-4 {middle dot} FasL Induces Alloantigen-Specific Hyporesponsiveness by Elhalel, Michal Dranitzki, Huang, Jui-Han, Schmidt, William, Rachmilewitz, Jacob, Tykocinski, Mark L

“…The APC:T cell interface can be effectively targeted with immunotherapeutic proteins. We previously described a unique trans signal converter protein, CTLA-4…”
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