Search Results - "TYBRING, Gunnel"

Impact of Cytochrome P450 2C19 Polymorphisms on Citalopram/Escitalopram Exposure: A Systematic Review and Meta-Analysis by Chang, Ming, Tybring, Gunnel, Dahl, Marja-Liisa, Lindh, Jonatan D.

“…Background Citalopram and escitalopram, selective serotonin reuptake inhibitors, are primarily metabolized by cytochrome P450 (CYP) 2C19, which is a highly…”
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Quality and Quantity of Saliva DNA Obtained from the Self-administrated Oragene Method—A Pilot Study on the Cohort of Swedish Men by Rylander-Rudqvist, Tove, Håkansson, Niclas, Tybring, Gunnel, Wolk, Alicja

“…Self-collection of saliva has the potential to provide molecular epidemiologic studies with DNA in a user-friendly way. We evaluated the new Oragene saliva…”
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Metabolomic Quality Assessment of EDTA Plasma and Serum Samples by Malm, Linus, Tybring, Gunnel, Moritz, Thomas, Landin, Britta, Galli, Joakim

“…Handling and processing of blood can significantly alter the molecular composition and consistency of biobank samples and can have a major impact on the…”
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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers by Ghotbi, Roza, Gomez, Alvin, Milani, Lili, Tybring, Gunnel, Syvänen, Ann-Christine, Bertilsson, Leif, Ingelman-Sundberg, Magnus, Aklillu, Eleni

“…The basis for interindividual variation in the CYP1A2 gene expression is not fully understood and the known genetic polymorphisms in the gene provide no…”
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Large-Scale Zygosity Testing Using Single Nucleotide Polymorphisms by Hannelius, Ulf, Gherman, Loreana, Mäkelä, Ville-Veikko, Lindstedt, Astrid, Zucchelli, Marco, Lagerberg, Camilla, Tybring, Gunnel, Kere, Juha, Lindgren, Cecilia M

“…A requirement for performing robust genetic and statistical analyses on twins is correctly assigned zygosities. In order to increase the power to detect small…”
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A Biospecimen Proficiency Testing Program for Biobank Accreditation: Four Years of Experience by Gaignaux, Amélie, Ashton, Garry, Coppola, Domenico, De Souza, Yvonne, De Wilde, Annemieke, Eliason, James, Grizzle, William, Guadagni, Fiorella, Gunter, Elaine, Koppandi, Iren, Shea, Katheryn, Shi, Tim, Stein, Julie A, Sobel, Mark E, Tybring, Gunnel, Van den Eynden, Gert, Betsou, Fay

“…Biobanks produce and distribute biospecimens, ensuring their fitness for purpose and accurately qualifying them before distribution. In their efforts toward…”
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Pharmacokinetics of losartan and its metabolite E‐3174 in relation to the CYP2C9 genotype by Yasar, Ümit, Forslund‐Bergengren, Cecilia, Tybring, Gunnel, Dorado, Pedro, LLerena, Adrián, Sjöqvist, Folke, Eliasson, Erik, Dahl, Marja‐Liisa

“…Background And Aim Losartan is metabolized by polymorphic CYP2C9 to E‐3174. Our aim was to evaluate the pharmacokinetics of losartan and E‐3174 in relation to…”
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Role of CYP2C9 Polymorphism in Losartan Oxidation by YASAR, Ümit, TYBRING, Gunnel, HIDESTRAND, Mats, OSCARSON, Mikael, INGELMAN-SUNDBERG, Magnus, DAHL, Marja-Liisa, ELIASSON, Erik

“…Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to an active carboxylic acid metabolite, E-3174. The aim of the…”
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Different Enantioselective 9-Hydroxylation of Risperidone by the Two Human CYP2D6 and CYP3A4 Enzymes by YASUI-FURUKORI, Norio, HIDESTRAND, Mats, SPINA, Edoardo, FACCIOLA, Gabriella, SCORDO, Maria Gabriella, TYBRING, Gunnel

“…The antipsychotic agent risperidone, is metabolized by different cytochrome P-450 (CYP) enzymes, including CYP2D6, to the active 9-hydroxyrisperidone, which is…”
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Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes by Herrlin, Karin, Yasui‐Furukori, Norio, Tybring, Gunnel, Widén, Jolanta, Gustafsson, Lars L., Bertilsson, Leif

“…Aims  To investigate pharmacokinetics of the enantiomers of citalopram (CT) and its metabolites desmethylcitalopram (DCT) and didesmethylcitalopram (DDCT) in…”
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Female-Predominant Expression of Fatty Acid Translocase/CD36 in Rat and Human Liver by Ståhlberg, Nina, Rico-Bautista, Elizabeth, Fisher, Rachel M, Wu, Xuxia, Cheung, Louisa, Flores-Morales, Amilcar, Tybring, Gunnel, Norstedt, Gunnar, Tollet-Egnell, Petra

“…The aim of this study was to identify genes for hepatic fuel metabolism with a gender-differentiated expression and to determine which of these that might be…”
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Cytochrome P 450 isoforms involved in melatonin metabolism in human liver microsomes by Facciolá, Gabriella, Hidestrand, Mats, von Bahr, Christer, Tybring, Gunnel

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Identification of cytochromes P 450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro by Ufer, Mike, Svensson, Jan O., Krausz, Kristopher W., Gelboin, Harry V., Rane, Anders, Tybring, Gunnel

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Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19) by Christensen, Magnus, Tybring, Gunnel, Mihara, Kazuo, Yasui‐Furokori, Norio, Carrillo, Juan Antonio, Ramos, Sara I., Andersson, Katarina, Dahl, Marja‐Liisa, Bertilsson, Leif

“…Objectives Fluvoxamine is metabolized by the polymorphic cytochrome P450 (CYP) 2D6 and the smoking‐inducible CYP1A2. Therapeutic doses of fluvoxamine inhibit…”
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The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro by YASAR, Ümit, ELIASSON, Erik, FORSLUND-BERGENGREN, Cecilia, TYBRING, Gunnel, GADD, Malin, SJÖQVIST, Folke, DAHL, Marja-Liisa

“…The polymorphic cytochrome P450 enzyme 2C9 (CYP2C9) catalyses the metabolism of many drugs including S-warfarin, acenocoumarol, phenytoin, tolbutamide,…”
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Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects by Tybring, Gunnel, Böttiger, Ylva, Widén, Jolanta, Bertilsson, Leif

“…Stereoselective disposition of omeprazole and its formed 5‐hydroxy metabolite were studied in five poor metabolizers and five extensive metabolizers of…”
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Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: A pilot study by Härtter, Sebastian, Ursing, Carina, Morita, Sachiyo, Tybring, Gunnel, Bahr, Christer, Christensen, Magnus, Röjdmark, Sven, Bertilsson, Leif

“…Background Melatonin is a hormone that is metabolized by cytochrome P450 (CYP) 1A2 to its main primary metabolite 6‐hydroxymelatonin. We therefore evaluated…”
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Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man by MIRGHANI, Rajaa A, ERICSSON, Örjan, TYBRING, Gunnel, GUSTAFSSON, Lars L, BERTILSSON, Leif

“…To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual…”
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Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway by Mirghani, Rajaa A, Yasar, Umit, Zheng, Tao, Cook, James M, Gustafsson, Lars L, Tybring, Gunnel, Ericsson, Orjan

“…The formation kinetics of 3-hydroxyquinine, 2′-quininone, (10 S )-11-dihydroxydihydroquinine, and (10 R )-11-dihydroxydihydroquinine were investigated in…”
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Pharmacokinetics of nortriptyline and its 10‐hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes by Yue, Qun‐Ying, Zhong, Zhi‐Hui, Tybring, Gunnel, Dalén, Per, Dahl, Marja‐Liisa, Bertilsson, Leif, Sjöqvist, Folke

“…Objectives To study the impact of the CYP2D6*10 allele on the disposition of nortriptyline in Chinese subjects. Methods A single dose of 25 mg nortriptyline…”
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