Search Results - "TYACKE, Robin J"

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin by Carhart-Harris, Robin L, Erritzoe, David, Williams, Tim, Stone, James M, Reed, Laurence J, Colasanti, Alessandro, Tyacke, Robin J, Leech, Robert, Malizia, Andrea L, Murphy, Kevin, Hobden, Peter, Evans, John, Feilding, Amanda, Wise, Richard G, Nutt, David J

“…Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very…”
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Imidazoline-I2 PET Tracers in Neuroimaging by Parker, Christine A, Nutt, David J, Tyacke, Robin J

“…Targeting neuroinflammation, and in particular, microglial activation and astrocytosis, is a current area of the focus of new treatment interventions for a…”
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Measuring endogenous 5-HT release by emission tomography: promises and pitfalls by Paterson, Louise M, Tyacke, Robin J, Nutt, David J, Knudsen, Gitte M

“…Molecular in vivo neuroimaging techniques can be used to measure regional changes in endogenous neurotransmitters, evoked by challenges that alter synaptic…”
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Functional Alternatives to Alcohol by Nutt, David J., Tyacke, Robin J., Spriggs, Meg, Jacoby, Vanessa, Borthwick, Alan D., Belelli, Delia

“…The consumption of alcohol is associated with well-known health harms and many governments worldwide are actively engaged in devising approaches to reduce…”
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Impact of COVID-19 restrictions on alcohol consumption behaviours by Palmer, Emily O. C., Trender, William, Tyacke, Robin J., Hampshire, Adam, Lingford-Hughes, Anne

“…We aimed to evaluate how coronavirus (COVID-19) restrictions had altered individual's drinking behaviours, including consumption, hangover experiences, and…”
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Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site by Tyacke, Robin J., Fisher, Amy, Robinson, Emma S.J., Grundt, Peter, Turner, Emma M., Husbands, Stephen M., Hudson, Alan L., Parker, Christine A., Nutt, David J.

“…The density of the Imidazoline2 binding site (I2BS) has been shown to change in psychiatric conditions such as depression and addiction, along with…”
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First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site by Venkataraman, Ashwin V., Keat, Nicholas, Myers, James F., Turton, Samuel, Mick, Inge, Gunn, Roger N., Rabiner, Eugenii A., Passchier, Jan, Parker, Christine A., Tyacke, Robin J., Nutt, David J.

“…Background We measured whole body distribution of 11 C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline 2 binding site. The…”
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Identification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site by Kimura, Atsuko, Tyacke, Robin J, Robinson, James J, Husbands, Stephen M, Minchin, Michael C.W, Nutt, David J, Hudson, Alan L

“…Abstract Drugs that bind to imidazoline binding proteins have major physiological actions. To date, three subtypes of such proteins, I1 , I2 and I3 , have been…”
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In vivo imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer's disease by Mirzaei, Nazanin, Tang, Sac Pham, Ashworth, Sharon, Coello, Christopher, Plisson, Christophe, Passchier, Jan, Selvaraj, Vimal, Tyacke, Robin J., Nutt, David J., Sastre, Magdalena

“…Microglial activation has been linked with deficits in neuronal function and synaptic plasticity in Alzheimer's disease (AD). The mitochondrial translocator…”
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Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load by Calsolaro, Valeria, Matthews, Paul M., Donat, Cornelius K., Livingston, Nicholas R., Femminella, Grazia D., Guedes, Sandra Silva, Myers, Jim, Fan, Zhen, Tyacke, Robin J., Venkataraman, Ashwin V., Perneczky, Robert, Gunn, Roger, Rabiner, Eugenii A., Gentleman, Steve, Parker, Christine A., Murphy, Philip S., Wren, Paul B., Hinz, Rainer, Sastre, Magdalena, Nutt, David J., Edison, Paul

“…11 C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte…”
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Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals by Livingston, Nicholas R., Calsolaro, Valeria, Hinz, Rainer, Nowell, Joseph, Raza, Sanara, Gentleman, Steve, Tyacke, Robin J., Myers, Jim, Venkataraman, Ashwin V., Perneczky, Robert, Gunn, Roger N., Rabiner, Eugenii A., Parker, Christine A., Murphy, Philip S., Wren, Paul B., Nutt, David J., Matthews, Paul M., Edison, Paul

“…Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo…”
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Synthesis and in vivo evaluation of [11C]BU99008 as a ligand for the imidazoline I2 binding site by Kealey, Steven, Husbands, Stephen, Casey, Emma M., Salinas, Cristian A., Parker, Christine A., Jakobsen, Steen, Tyacke, Robin J., Nutt, David J., Gee, Antony D.

“…Background: Imidazoline-2 binding sites (I2BS) are thought to be mainly located on glial cells, and have prompted interest in neurodegenerative and…”
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Optimising PET approaches to measuring 5-HT release in human brain by Tyacke, Robin J., Nutt, David J.

“…ABSTRACT A major goal in neuroscience is the measurement of neurotransmitters in living human brain. To date this has only been done reliably with dopamine…”
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Imaging Endogenous Opioid Peptide Release with [11C]Carfentanil and [3H]Diprenorphine: Influence of Agonist-Induced Internalization by Quelch, Darren R, Katsouri, Loukia, Nutt, David J, Parker, Christine A, Tyacke, Robin J

“…Understanding the cellular processes underpinning the changes in binding observed during positron emission tomography neurotransmitter release studies may aid…”
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Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment by Borissova, Anna, Ferguson, Bart, Wall, Matthew B, Morgan, Celia JA, Carhart-Harris, Robin L, Bolstridge, Mark, Bloomfield, Michael AP, Williams, Tim M, Feilding, Amanda, Murphy, Kevin, Tyacke, Robin J, Erritzoe, David, Stewart, Lorna, Wolff, Kim, Nutt, David, Curran, H Valerie, Lawn, Will

“…Background: 3,4-Methylenedioxymethamphetamine (MDMA) is being actively researched as an adjunct to psychotherapy. It may be beneficial to trust, empathy and…”
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Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease: an in vivo11C-BU99008 PET study by Wilson, Heather, Dervenoulas, George, Pagano, Gennaro, Tyacke, Robin J, Polychronis, Sotirios, Myers, Jim, Gunn, Roger N, Rabiner, Eugenii A, Nutt, David, Politis, Marios

“…Astroglia are multifunctional cells that regulate neuroinflammation and maintain homeostasis within the brain. Astroglial α-synuclein-positive cytoplasmic…”
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Evaluation of 11 C-BU99008, a PET Ligand for the Imidazoline 2 Binding Site in Human Brain by Tyacke, Robin J, Myers, Jim F M, Venkataraman, Ashwin, Mick, Inge, Turton, Samuel, Passchier, Jan, Husbands, Stephen M, Rabiner, Eugenii A, Gunn, Roger N, Murphy, Philip S, Parker, Christine A, Nutt, David J

“…The imidazoline binding site (I BS) is thought to be expressed in glia and implicated in the regulation of glial fibrillary acidic protein. A PET ligand for…”
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Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Site in Human Brain by Tyacke, Robin J, Myers, Jim F M, Venkataraman, Ashwin, Mick, Inge, Turton, Samuel, Passchier, Jan, Husbands, Stephen M, Rabiner, Eugenii A, Gunn, Roger N, Murphy, Philip S, Parker, Christine A, Nutt, David J

“…The imidazoline2 binding site (I2BS) is thought to be expressed in glia and implicated in the regulation of glial fibrillary acidic protein. A PET ligand for…”
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The influence of different cellular environments on PET radioligand binding: An application to D2/3-dopamine receptor imaging by Quelch, Darren R., Withey, Sarah L., Nutt, David J., Tyacke, Robin J., Parker, Christine A.

“…Various D2/3 receptor PET radioligands are sensitive to endogenous dopamine release in vivo. The Occupancy Model is generally used to interpret changes in…”
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Distribution of [3H]BU224, a selective imidazoline I2 binding site ligand, in rat brain by ROBINSON, Emma S. J, TYACKE, Robin J, NUTT, David J, HUDSON, Alan L

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