Search Results - "TUZMEN, Sukru"

Update on the clinical utility of an RNA interference-based treatment: focus on Patisiran by Rizk, Malak, Tüzmen, Şükrü

“…RNA interference (RNAi) is a naturally existing endogenous mechanism for post-transcriptional gene regulation, nowadays commonly utilized for functional…”
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Functional evidence implicating S100P in prostate cancer progression by Basu, Gargi D., Azorsa, David O., Kiefer, Jeffrey A., Rojas, Angela M., Tuzmen, Sukru, Barrett, Michael T., Trent, Jeffrey M., Kallioniemi, Olli, Mousses, Spyro

“…S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. We have…”
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NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells by Savas, Sevtap, Azorsa, David O, Jarjanazi, Hamdi, Ibrahim-Zada, Irada, Gonzales, Irma M, Arora, Shilpi, Henderson, Meredith C, Choi, Yun Hee, Briollais, Laurent, Ozcelik, Hilmi, Tuzmen, Sukru

“…Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential…”
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Human SNPs resulting in premature stop codons and protein truncation by Savas, Sevtap, Tuzmen, Sukru, Ozcelik, Hilmi

“…Single nucleotide polymorphisms (SNPs) constitute the most common type of genetic variation in humans. SNPs introducing premature termination codons (PTCs),…”
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Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine by Jarjanazi, Hamdi, Kiefer, Jeffrey, Savas, Sevtap, Briollais, Laurent, Tuzmen, Sukru, Pabalan, Noel, Ibrahim-Zada, Irada, Mousses, Spyro, Ozcelik, Hilmi

“…Chemotherapy is a major treatment modality for individuals affected by cancer. Currently, a number of genome-based technologies are being adopted to identify…”
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Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification by KUUSELO, Riina, SAVINAINEN, Kimmo, AZORSA, David O, BASU, Gargi D, KARHU, Ritva, TUZMEN, Sukru, MOUSSES, Spyro, KALLIONIEMI, Anne

“…Pancreatic cancer is a highly aggressive disease characterized by poor prognosis and vast genetic instability. Recent microarray-based, genome-wide surveys…”
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Validation of short interfering RNA knockdowns by quantitative real-time PCR by Tuzmen, Sukru, Kiefer, Jeff, Mousses, Spyro

“…RNA interference (RNAi) is a natural mechanism, that is triggered by the introduction of double-stranded RNA into a cell. The long double-stranded RNA is then…”
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Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer by Kallioniemi, Olli-P, Mousses, Spyro, Huusko, Pia, Ponciano-Jackson, Damaris, Wolf, Maija, Kiefer, Jeff A, Azorsa, David O, Tuzmen, Sukru, Weaver, Don, Robbins, Christiane, Moses, Tracy, Allinen, Minna, Hautaniemi, Sampsa, Chen, Yidong, Elkahloun, Abdel, Basik, Mark, Bova, G Steven, Bubendorf, Lukas, Lugli, Alessandro, Sauter, Guido, Schleutker, Johanna, Ozcelik, Hilmi, Elowe, Sabine, Pawson, Tony, Trent, Jeffrey M, Carpten, John D

“…The identification of tumor-suppressor genes in solid tumors by classical cancer genetics methods is difficult and slow. We combined nonsense-mediated RNA…”
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Abstract 4023: ARID1A is a candidate tumor suppressor gene in breast cancer by Chabot, Catherine, Mamo, Aline, Cavallone, Luca, Tuzmen, Sukru, Hassan, Saima, Edgren, Henrik, Ferrario, Cristiano, Aleynikova, Olga, Przybytkowska, Ewa, Malcolm, Kristin, Kallioniemi, Olli, Tonin, Patricia, Mousses, Spyro, Basik, Mark

“…Abstract Tumor suppressor genes (TSGs) have been classically defined as genes whose loss of function in tumor cells contributes to the formation and/or…”
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Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes by Gökmen-Polar, Yesim, Mehta, Rutika, Tuzmen, Sukru, Mousses, Spyro, Thorat, Mangesh A, Sanders, Kerry L, Turbin, Dmitry, Leung, Samuel, Huntsman, David G, Sledge, George W. Jr, Badve, Sunil

“…Protein kinase C betaII (PKCβII) represents a novel potential target for anticancer therapies in breast cancer. In order to identify patient subgroups which…”
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Validation of signalling pathways: Case study of the p16-mediated pathway by Akçay, Nimet İlke, Bashirov, Rza, Tüzmen, Şükrü

“…p16 is recognized as a tumor suppressor gene due to the prevalence of its genetic inactivation in all types of human cancers. Additionally, p16 gene plays a…”
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Differential Regulation of Lysyl Oxidase Gene Family Isoforms by Steroid Hormones in Human Stromal Endometrial Cells by Baez, Perla, Ruiz, Abigail, Colon, Maricarmen, Perez, Nivette, Santiago, Pedro, Tuzmen, Sukru, Flores, Idhaliz

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Differential subcellular expression of protein kinase C betall in breast cancer: correlation with breast cancer subtypes by GÖKMEN-POLAR, Yesim, MEHTA, Rutika, BADVE, Sunil, TUZMEN, Sukru, MOUSSES, Spyro, THORAT, Mangesh A, SANDERS, Kerry L, TURBIN, Dmitry, LEUNG, Samuel, HUNTSMAN, David G, SLEDGE, George W

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Site-directed mutagenesis by Carrigan, Patricia E, Ballar, Petek, Tuzmen, Sukru

“…The technique of site-directed mutagenesis has been used to characterize gene and protein structure-function relationships, protein-protein interactions,…”
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RNAi-based functional pharmacogenomics by Tuzmen, Sukru, Tuzmen, Pinar, Arora, Shilpi, Mousses, Spyro, Azorsa, David

“…Experimental alteration of gene expression is a powerful technique for functional characterization of disease genes. RNA interference (RNAi) is a naturally…”
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Genetic predisposition to β-thalassemia and sickle cell anemia in Turkey: a molecular diagnostic approach by Basak, A Nazli, Tuzmen, Sukru

“…The thalassemia syndromes are a diverse group of inherited disorders that can be characterized according to their insufficient synthesis or absent production…”
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Okullarda yönetim etkinlikleri by Türkmen, Şükrü

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Rare β-Thalassemia Mutation in a Turkish Patient: FSC-36/37 (-T) by TADMOURI, GHAZI OMAR, TÜZMEN, ŞÜKRÜ, BAŞAK, A. NAZLI

“…We describe the rare β-thalassemia mutation at codons 36/37 (-T) for the first time in Turkey. The propositus is a Turkish patient with β-thalassemia major who…”
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Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets by Mehraei, Mani, Bashirov, Rza, Tüzmen, Şükrü

“…Recent molecular studies provide important clues into treatment of [Formula: see text]-thalassemia, sickle-cell anaemia and other [Formula: see text]-globin…”
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PRENATAL DIAGNOSIS OF β-THALASSAEMIA AND SICKLE CELL ANAEMIA IN TURKEY by TÜZMEN, ŞÜKRÜ, TADMOURI, GHAZI O., ÖZER, AYŞE, BAIG, SHAHID M., ÖZÇELIK, HILMI, BAŞARAN, SEHER, BAŞAK, A. NAZLI

“…This paper reports our experience of molecular analysis and diagnosis of β‐thalassaemia and sickle cell anaemia (HbS) in 70 prospective parents of Turkish…”
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