Search Results - "TUVESON, David A"

Diversity and Biology of Cancer-Associated Fibroblasts by Biffi, Giulia, Tuveson, David A

“…Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal…”
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Stromal biology and therapy in pancreatic cancer: a changing paradigm by Neesse, Albrecht, Algül, Hana, Tuveson, David A, Gress, Thomas M

“…Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid tumours and poses an unsolved problem in cancer medicine. Despite the…”
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The Promise and Perils of Antioxidants for Cancer Patients by Chandel, Navdeep S, Tuveson, David A

“…It has been proposed that reactive oxygen species (ROS) cause mutations, and thus cancer, and that antioxidants counter this effect, but studies suggest that…”
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The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 by Palm, Wilhelm, Park, Youngkyu, Wright, Kevin, Pavlova, Natalya N., Tuveson, David A., Thompson, Craig B.

“…Despite being surrounded by diverse nutrients, mammalian cells preferentially metabolize glucose and free amino acids. Recently, Ras-induced macropinocytosis…”
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In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma by Karreth, Florian A., Tay, Yvonne, Perna, Daniele, Ala, Ugo, Tan, Shen Mynn, Rust, Alistair G., DeNicola, Gina, Webster, Kaitlyn A., Weiss, Dror, Perez-Mancera, Pedro A., Krauthammer, Michael, Halaban, Ruth, Provero, Paolo, Adams, David J., Tuveson, David A., Pandolfi, Pier Paolo

“…We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements…”
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Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches by Tuveson, David A., Neoptolemos, John P.

“…Although metastasis is a major cause of morbidity and mortality in patients with pancreatic cancer, the requisite events are currently unknown. In this issue…”
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Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer by Cheung, Eric C., DeNicola, Gina M., Nixon, Colin, Blyth, Karen, Labuschagne, Christiaan F., Tuveson, David A., Vousden, Karen H.

“…The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC)…”
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Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts by Elyada, Ela, Bolisetty, Mohan, Laise, Pasquale, Flynn, William F, Courtois, Elise T, Burkhart, Richard A, Teinor, Jonathan A, Belleau, Pascal, Biffi, Giulia, Lucito, Matthew S, Sivajothi, Santhosh, Armstrong, Todd D, Engle, Dannielle D, Yu, Kenneth H, Hao, Yuan, Wolfgang, Christopher L, Park, Youngkyu, Preall, Jonathan, Jaffee, Elizabeth M, Califano, Andrea, Robson, Paul, Tuveson, David A

“…Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a…”
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ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity by Moral, John Alec, Leung, Joanne, Rojas, Luis A., Ruan, Jennifer, Zhao, Julia, Sethna, Zachary, Ramnarain, Anita, Gasmi, Billel, Gururajan, Murali, Redmond, David, Askan, Gokce, Bhanot, Umesh, Elyada, Ela, Park, Youngkyu, Tuveson, David A., Gönen, Mithat, Leach, Steven D., Wolchok, Jedd D., DeMatteo, Ronald P., Merghoub, Taha, Balachandran, Vinod P.

“…Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 ,…”
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The Pancreas Cancer Microenvironment by FEIG, Christine, GOPINATHAN, Aarthi, NEESSE, Albrecht, CHAN, Derek S, COOK, Natalie, TUVESON, David A

“…Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in more than 250,000 deaths per year worldwide. Despite extensive efforts,…”
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Deciphering cancer fibroblasts by Biffi, Giulia, Tuveson, David A

“…In this issue of , Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow-derived cells that uniquely promotes breast cancer…”
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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer by Feig, Christine, Jones, James O., Kraman, Matthew, Wells, Richard J. B., Deonarine, Andrew, Chan, Derek S., Connell, Claire M., Roberts, Edward W., Qi Zhao, Caballero, Otavia L., Teichmann, Sarah A., Janowitz, Tobias, Jodrell, Duncan I., Tuveson, David A., Fearon, Douglas T.

“…An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite…”
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Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma by Tian, Chenxi, Öhlund, Daniel, Rickelt, Steffen, Lidström, Tommy, Huang, Ying, Hao, Liangliang, Zhao, Renee T, Franklin, Oskar, Bhatia, Sangeeta N, Tuveson, David A, Hynes, Richard O

“…The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains poor despite decades of effort. The abundant extracellular matrix (ECM) in PDAC comprises a…”
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer by Öhlund, Daniel, Handly-Santana, Abram, Biffi, Giulia, Elyada, Ela, Almeida, Ana S, Ponz-Sarvise, Mariano, Corbo, Vincenzo, Oni, Tobiloba E, Hearn, Stephen A, Lee, Eun Jung, Chio, Iok In Christine, Hwang, Chang-Il, Tiriac, Hervé, Baker, Lindsey A, Engle, Dannielle D, Feig, Christine, Kultti, Anne, Egeblad, Mikala, Fearon, Douglas T, Crawford, James M, Clevers, Hans, Park, Youngkyu, Tuveson, David A

“…Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease…”
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Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis by Nielsen, Sebastian R., Quaranta, Valeria, Linford, Andrea, Emeagi, Perpetua, Rainer, Carolyn, Santos, Almudena, Ireland, Lucy, Sakai, Takao, Sakai, Keiko, Kim, Yong-Sam, Engle, Dannielle, Campbell, Fiona, Palmer, Daniel, Ko, Jeong Heon, Tuveson, David A., Hirsch, Emilio, Mielgo, Ainhoa, Schmid, Michael C.

“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better therapies are urgently needed. Macrophages enhance metastasis in…”
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Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization by Senturk, Serif, Shirole, Nitin H., Nowak, Dawid G., Corbo, Vincenzo, Pal, Debjani, Vaughan, Alexander, Tuveson, David A., Trotman, Lloyd C., Kinney, Justin B., Sordella, Raffaella

“…The CRISPR/Cas9 system is a powerful tool for studying gene function. Here, we describe a method that allows temporal control of CRISPR/Cas9 activity based on…”
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Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors by Ireland, Lucy, Santos, Almudena, Ahmed, Muhammad S, Rainer, Carolyn, Nielsen, Sebastian R, Quaranta, Valeria, Weyer-Czernilofsky, Ulrike, Engle, Danielle D, Perez-Mancera, Pedro A, Coupland, Sarah E, Taktak, Azzam, Bogenrieder, Thomas, Tuveson, David A, Campbell, Fiona, Schmid, Michael C, Mielgo, Ainhoa

“…Tumor-associated macrophages (TAM) and myofibroblasts are key drivers in cancer that are associated with drug resistance in many cancers, including pancreatic…”
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis by Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid…”
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TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma by Somerville, Tim D.D., Xu, Yali, Miyabayashi, Koji, Tiriac, Hervé, Cleary, Cristian R., Maia-Silva, Diogo, Milazzo, Joseph P., Tuveson, David A., Vakoc, Christopher R.

“…The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the…”
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Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer by Quaranta, Valeria, Rainer, Carolyn, Nielsen, Sebastian R, Raymant, Meirion L, Ahmed, Muhammad S, Engle, Dannielle D, Taylor, Arthur, Murray, Trish, Campbell, Fiona, Palmer, Daniel H, Tuveson, David A, Mielgo, Ainhoa, Schmid, Michael C

“…The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune…”
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