Search Results - "TURNBULL, ANDREW V"

Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure by Liu, Li, Trent, Chad M., Fang, Xiang, Son, Ni-Huiping, Jiang, HongFeng, Blaner, William S., Hu, Yunying, Yin, Yu-Xin, Farese, Robert V., Homma, Shunichi, Turnbull, Andrew V., Eriksson, Jan W., Hu, Shi-Lian, Ginsberg, Henry N., Huang, Li-Shin, Goldberg, Ira J.

“…Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in triglyceride synthesis, the conversion of diacylglycerol (DAG) to triglyceride. Dgat1−/−…”
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action by TURNBULL, ANDREW V, RIVIER, CATHERINE L

“…ANDREW V. TURNBULL AND CATHERINE L. RIVIER The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California; and North Western…”
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Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats[S] by Schober, Gudrun, Arnold, Myrtha, Birtles, Susan, Buckett, Linda K., Pacheco-López, Gustavo, Turnbull, Andrew V., Langhans, Wolfgang, Mansouri, Abdelhak

“…Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine…”
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Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying by Ables, Gene P., Yang, Kryscilla Jian Zhang, Vogel, Silke, Hernandez-Ono, Antonio, Yu, Shuiqing, Yuen, Jason J., Birtles, Susan, Buckett, Linda K., Turnbull, Andrew V., Goldberg, Ira J., Blaner, William S., Huang, Li-Shin, Ginsberg, Henry N.

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1…”
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DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S] by Liu, Li, Yu, Shuiqing, Khan, Raffay S., Ables, Gene P., Bharadwaj, Kalyani G., Hu, Yunying, Huggins, Lesley A., Eriksson, Jan W., Buckett, Linda K., Turnbull, Andrew V., Ginsberg, Henry N., Blaner, William S., Huang, Li-Shin, Goldberg, Ira J.

“…Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are…”
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Diacylglycerol acyltransferases: Potential roles as pharmacological targets by Zammit, Victor A, Buckett, Linda K, Turnbull, Andrew V, Wure, Haja, Proven, Andrew

“…Triglyceride (TG) synthesis occurs in many cell-types, but only the adipocyte is specialised for TG storage. The increased incidence of obesity and its…”
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Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor by Birch, Alan M, Birtles, Susan, Buckett, Linda K, Kemmitt, Paul D, Smith, Graham J, Smith, Tim J. D, Turnbull, Andrew V, Wang, Steven J. Y

“…Inhibition of DGAT-1 is increasingly seen as an attractive mechanism with the potential for treatment of obesity and other elements of the metabolic syndrome…”
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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor by Vaughan, Joan, Donaldson, Cynthia, Bittencourt, Jackson, Perrin, Marilyn H, Lewis, Kathy, Sutton, Steven, Chan, Raymond, Turnbull, Andrew V, Lovejoy, David, Rivier, Catherine, Rivier, Jean, Sawchenko, Paul E, Vale, Wylie

“…Corticotropin-releasing factor (CRF), a peptide first isolated from mammalian brain, is critical in the regulation of the pituitary-adrenal axis, and in…”
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Medicinal Chemistry of Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) by Scott, James S, Goldberg, Frederick W, Turnbull, Andrew V

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme primarily responsible for the regulation of intracellular cortisol levels. Inhibition of…”
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Interleukin-6 Is an Afferent Signal to the Hypothalamo-Pituitary-Adrenal Axis during Local Inflammation in Mice by Turnbull, Andrew V, Prehar, Sukhpal, Kennedy, Adam R, Little, Roderick A, Hopkins, Stephen J

“…The cytokines IL-1 and IL-6 are able to induce prostaglandin (PG)-dependent activation of the hypothalamo-pituitary-adrenal axis (HPAA) and are thought to play…”
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Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats by Turnbull, Andrew V, Ellershaw, Laraine, Masters, Dave J, Birtles, Susan, Boyer, Scott, Carroll, Debbie, Clarkson, Paul, Loxham, Sue J G, McAulay, Pat, Teague, Joanne L, Foote, Kevin M, Pease, J Elizabeth, Block, Michael H

“…Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats Andrew V. Turnbull , Laraine Ellershaw , Dave J. Masters , Susan…”
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Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism by Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sascha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Goeritzer, Madeleine, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, M. Mahmood, Groen, Albert K., Kratky, Dagmar

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and…”
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11-Dehydrocorticosterone Causes Metabolic Syndrome, Which Is Prevented when 11β-HSD1 Is Knocked Out in Livers of Male Mice by Harno, Erika, Cottrell, Elizabeth C, Keevil, Brian G, DeSchoolmeester, Joanne, Bohlooly-Y, Mohammad, Andersén, Harriet, Turnbull, Andrew V, Leighton, Brendan, White, Anne

“…Metabolic syndrome is growing in importance with the rising levels of obesity, type 2 diabetes, and insulin resistance. Metabolic syndrome shares many…”
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11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms by Harno, Erika, Cottrell, Elizabeth C, Yu, Alice, DeSchoolmeester, Joanne, Gutierrez, Pablo Morentin, Denn, Mark, Swales, John G, Goldberg, Fred W, Bohlooly-Y, Mohammad, Andersén, Harriet, Wild, Martin J, Turnbull, Andrew V, Leighton, Brendan, White, Anne

“…The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a target for novel type 2 diabetes and obesity therapies based on the premise that lowering of…”
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Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice by Goldberg, Frederick W, Dossetter, Alexander G, Scott, James S, Robb, Graeme R, Boyd, Scott, Groombridge, Sam D, Kemmitt, Paul D, Sjögren, Tove, Gutierrez, Pablo Morentin, deSchoolmeester, Joanne, Swales, John G, Turnbull, Andrew V, Wild, Martin J

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been widely considered by the pharmaceutical industry as a target to treat metabolic syndrome in type II…”
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Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism by Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sasha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, Mahmood M., Groen, Albert K., Kratky, Dagmar

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Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687) by Barlind, Jonas G., Bauer, Udo A., Birch, Alan M., Birtles, Susan, Buckett, Linda K., Butlin, Roger J., Davies, Robert D. M., Eriksson, Jan W., Hammond, Clare D., Hovland, Ragnar, Johannesson, Petra, Johansson, Magnus J., Kemmitt, Paul D., Lindmark, Bo T., Morentin Gutierrez, Pablo, Noeske, Tobias A., Nordin, Andreas, O’Donnell, Charles J., Petersson, Annika U., Redzic, Alma, Turnbull, Andrew V., Vinblad, Johanna

“…A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and…”
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ACAT-selective and Nonselective DGAT1 Inhibition: Adrenocortical Effects—A Cross-species Comparison by Floettmann, Jan Eike, Buckett, Linda K., Turnbull, Andrew V., Smith, Tim, Hallberg, Carina, Birch, Alan, Lees, David, Jones, Huw B.

“…Acyl-coenzyme A: cholesterol O-Acyltransferase (ACAT) and Acyl-coenzyme A: diacylglycerol O-acyltransferase (DGAT) enzymes play important roles in synthesizing…”
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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes by McCoull, William, Addie, Matthew S., Birch, Alan M., Birtles, Susan, Buckett, Linda K., Butlin, Roger J., Bowker, Suzanne S., Boyd, Scott, Chapman, Stephen, Davies, Robert D.M., Donald, Craig S., Green, Clive P., Jenner, Chloe, Kemmitt, Paul D., Leach, Andrew G., Moody, Graeme C., Morentin Gutierrez, Pablo, Newcombe, Nicholas J., Nowak, Thorsten, Packer, Martin J., Plowright, Alleyn T., Revill, John, Schofield, Paul, Sheldon, Chris, Stokes, Steve, Turnbull, Andrew V., Wang, Steven J.Y., Whalley, David P., Matthew Wood, J.

“…A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand…”
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Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat by Loddick, S A, Turnbull, A V, Rothwell, N J

“…Interleukin-6 (IL-6) is a neurotrophic cytokine expressed in both neurons and glia. The present study shows that cerebral ischemia produced by permanent…”
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