Search Results - "TUOHY, V. K"

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis by RUDICK, R. A, RANSOHOFF, R. M, LEE, J.-C, PEPPLER, R, YU, M, MATHISEN, P. M, TUOHY, V. K

“…Recombinant interferon beta (IFNbeta) benefits patients with relapsing remitting multiple sclerosis (MS), but the mechanisms of action are unknown. We studied…”
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Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis by Glabinski, AR, Tani, M, Strieter, RM, Tuohy, VK, Ransohoff, RM

“…Chemokines are secreted peptides that exhibit selective chemoattractant properties for target leukocytes. Two subfamilies, alpha- and beta-chemokines, have…”
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Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis by WUJEK, JEROME R, BJARTMAR, CARL, RICHER, EDWARD, RANSOHOFF, RICHARD M, YU, MIN, TUOHY, VINCENT K, TRAPP, BRUCE D

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Most patients undergo an initial relapsing-remitting…”
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Diversity and plasticity of self recognition during the development of multiple sclerosis by Tuohy, V K, Yu, M, Weinstock-Guttman, B, Kinkel, R P

“…Recent studies using murine animal model systems indicate that clinical progression of autoimmune disease may be due to the sequential accumulation of…”
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In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis by Tani, M, Glabinski, AR, Tuohy, VK, Stoler, MH, Estes, ML, Ransohoff, RM

“…Reactive astrogliosis is a prominent pathological feature of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. It is…”
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Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis by Ransohoff, R M, Hamilton, T A, Tani, M, Stoler, M H, Shick, H E, Major, J A, Estes, M L, Thomas, D M, Tuohy, V K

“…Mononuclear leukocytes preferentially accumulate in the central nervous system (CNS) during the course of experimental autoimmune encephalomyelitis (EAE). To…”
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In vitro and in vivo inhibition of mitogen-driven T-cell activation by recombinant interferon beta by RUDICK, R. A, CARPENTER, C. S, COOKFAIR, D. L, TUOHY, V. K, RANSOHOFF, R. M

“…Recombinant interferon beta (rIFN beta) is being tested as experimental immunotherapy for exacerbating-remitting MS. To clarify the possible mechanisms of a…”
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Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease : a review by TUOHY, V. K

“…This article reviews recent advances in understanding the role of myelin proteolipid protein (PLP) in autoimmune demyelination. It is drawn largely from work…”
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Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice by Tuohy, VK, Lu, Z, Sobel, RA, Laursen, RA, Lees, MB

“…PLP is the major protein constituent of central nervous system myelin. We have previously shown that SJL/J (H-2s) mice develop an acute form of EAE after…”
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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells by Kyewski, Bruno, Klein, Ludger, Klugmann, Matthias, Nave, Klaus-Armin, Tuohy, V K

“…Intrathymic expression of tissue-specific self antigens may be involved in immunological tolerance and protection from autoimmune disease. We have analyzed the…”
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A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis by Tuohy, VK, Lu, ZJ, Sobel, RA, Laursen, RA, Lees, MB

“…Immunization of animals with proteolipid protein, the major protein constituent of central nervous system myelin, produces experimental allergic…”
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Pre-Emptive Targeting of the Epitope Spreading Cascade with Genetically Modified Regulatory T Cells During Autoimmune Demyelinating Disease by Yin, Ling, Yu, Min, Edling, Andrea E, Kawczak, Julie A, Mathisen, Peter M, Nanavati, Tania, Johnson, Justin M, Tuohy, Vincent K

“…Epitope spreading or endogenous self-priming has been implicated in mediating the progression of autoimmune disease. In the present study we created an…”
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Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice by Tuohy, Vincent K., Thomas, Dawn M.

“…Immunization of animals with myelin proteolipid protein (PLP) causes experimental autoimmune encephalomyelitis (EAE), a disease model that shares many features…”
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Generation of autonomously pathogenic neo-autoreactive TH1 cells during the development of the determinant spreading cascade in murine autoimmune encephalomyelitis by Yu, M., Johnson, J.M., Tuohy, V.K.

“…Chronic progression of autoimmune disease is accompanied by the acquisition of autoreactivity to new self‐determinants. Recent evidence indicates that this…”
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Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination by Cross, A H, Tuohy, V K, Raine, C S

“…Cells from 25 mice at different stages of experimental autoimmune encephalomyelitis (EAE) adoptively transferred using lymph node cells sensitized to a…”
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Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice by Tuohy, VK, Sobel, RA, Lees, MB

“…Strains of mice with diverse genetic backgrounds were tested for susceptibility to experimental allergic encephalomyelitis (EAE) induced by myelin proteolipid…”
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Regulation and function of central nervous system chemokines by Glabinski, A R, Tani, M, Aras, S, Stoler, M H, Tuohy, V K, Ransohoff, R M

“…In this paper, we discuss the potential involvement of a new family of cytokines, termed chemokines, in CNS inflammatory pathology. Chemokines are a family of…”
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Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides by Kennedy, MK, Tan, LJ, Dal Canto, MC, Tuohy, VK, Lu, ZJ, Trotter, JL, Miller, SD

“…Tolerization of SJL/J mice with splenocytes coupled with proteolipid protein (PLP), the major protein component of central nervous system myelin, resulted in…”
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Gene therapy in experimental autoimmune encephalomyelitis by MATHISEN, Peter M, TUOHY, Vincent K

“…Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then…”
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A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease by Yu, M, Johnson, J M, Tuohy, V K

“…The development of autoimmune disease is accompanied by the acquired recognition of new self-determinants, a process commonly referred to as determinant…”
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