Search Results - "TUNE, L. E"

Anticholinergic effects of medication in elderly patients by Tune, L E

“…Anticholinergic toxicity is a common problem in the elderly. It has many effects ranging from dry mouth, constipation, and visual impairments to confusion,…”
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Acetylcholine and delirium by Tune, L E, Egeli, S

“…The neurotransmitter acetylcholine has been implicated in animal and human studies of delirium. This chapter will briefly review the clinical studies focussing…”
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Diagnosis and Treatment of Alzheimer Disease and Related Disorders: Consensus Statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society by Small, Gary W, Rabins, Peter V, Barry, Patricia P, Buckholtz, Neil S, DeKosky, Steven T, Ferris, Steven H, Finkel, Sanford I, Gwyther, Lisa P, Khachaturian, Zaven S, Lebowitz, Barry D, McRae, Thomas D, Morris, John C, Oakley, Frances, Schneider, Lon S, Streim, Joel E, Sunderland, Trey, Teri, Linda A, Tune, Larry E

“…Objective.—A consensus conference on the diagnosis and treatment of Alzheimer disease (AD) and related disorders was organized by the American Association for…”
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Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging by MELTZER, C. C, ZUBIETA, J. K, BRANDT, J, TUNE, L. E, MAYBERG, H. S, FROST, J. J

“…Measurements of cerebral metabolism in patients with Alzheimer's disease (AD) using PET are artifactually depressed due to partial volume averaging of brain…”
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Alterations in the Functional Anatomy of Working Memory in Adult Attention Deficit Hyperactivity Disorder by Schweitzer, Julie B., Faber, Tracy L., Grafton, Scott T., Tune, Larry E., Hoffman, John M., Kilts, Clinton D.

“…OBJECTIVE: The authors used a functional neuroimaging study with a working memory probe to investigate the pathophysiology of attention deficit hyperactivity…”
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Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia by Barta, P E, Pearlson, G D, Powers, R E, Richards, S S, Tune, L E

“…Recent neuropathologic investigations in schizophrenia report smaller volume of medial temporal lobe structures. These findings are confirmed by preliminary…”
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Risperidone for the treatment of behavioral and psychological symptoms of dementia by Tune, L E

“…Risperidone offers physicians the unique combination of extensive, published clinical experience and a good safety profile for treating patients with dementia…”
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A chart review study of late-onset and early-onset schizophrenia by Pearlson, G D, Kreger, L, Rabins, P V, Chase, G A, Cohen, B, Wirth, J B, Schlaepfer, T B, Tune, L E

“…This chart review study compared 54 schizophrenic patients with onset of illness after age 45 years to 54 young and 22 elderly patients with early-onset…”
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Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics by WONG, D. F, WAGNER, H. N. JR, TOUNG, J. K. T, MALAT, J, WILLIAMS, J. A, Oï'TUAMA, L. A, SNYDER, S. H, TUNE, L. E, DANNALS, R. F, PEARLSON, G. D, LINKS, J. M, TAMMINGA, C. A, BROUSSOLLE, E. P, RAVERT, H. T, WILSON, A. A

“…In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with…”
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Serotonergic modulation of anticholinergic effects on cognition and behavior in elderly humans by LITTLE, J. T, BROOCKS, A, MARTIN, A, HILL, J. L, TUNE, L. E, MACK, C, CANTILLON, M, MOLCHAN, S, MURPHY, D. L, SUNDERLAND, T

“…Cholinergic neurotransmission is thought to be modulated by serotonin as documented in animal and human studies. We examined the effects of the muscarinic…”
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Serum anticholinergic activity levels and delirium in the elderly by Tune, L E

“…This article will briefly review the clinical studies focusing on measurement of serum levels of anticholinergic activity in delirious states. Three…”
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Association of elevated plasma anticholinergic activity with delirium in surgical patients by Golinger, R C, Peet, T, Tune, L E

“…In a surgical intensive care unit, plasma anticholinergic activity was significantly higher in nine delirious patients than in 16 patients without delirium…”
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Neuroleptic drugs in the management of behavioral symptoms of Alzheimer's disease by Tune, L E, Steele, C, Cooper, T

“…Physicians have long been wary of chronically administering neuroleptic drugs to the demented elderly for fear of significant side effects. In this article,…”
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Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls by Barta, Patrick E., Powers, Richard E., Aylward, Elizabeth H., Chase, Gary A., Harris, Gordon J., Rabins, Peter V., Tune, Larry E., Pearlson, Godfrey D.

“…Volumes of medial and lateral temporal lobe structures were assessed using magnetic resonance imaging (MRI) in 11 patients with late-life onset schizophrenia…”
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Quantitative D2 Dopamine Receptor PET and Structural MRI Changes in Late-Onset Schizophrenia by Pearlson, Godfrey D., Tune, Larry E., Wong, Dean F., Aylward, Elizabeth H., Barta, Patrick E., Powers, Richard E., Tien, Allen Y., Chase, Gary A., Harris, Gordon J., Rabins, Peter V.

“…Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly…”
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Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness by Wong, D F, Pearlson, G D, Tune, L E, Young, L T, Meltzer, C C, Dannals, R F, Ravert, H T, Reith, J, Kuhar, M J, Gjedde, A

“…In a previous study of 10 drug-naive schizophrenic patients, the density of D2 dopamine receptors was found to be elevated in the caudate nucleus. The study…”
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Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement by Nimgaonkar, V L, Wessely, S, Tune, L E, Murray, R M

“…A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial…”
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Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients by Tune, L E, Strauss, M E, Lew, M F, Breitlinger, E, Coyle, J T

“…The authors tested working or recent memory in 24 stabilized schizophrenic outpatients who were taking psychotropic medication. Memory performance did not…”
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Span of Apprehension Deficits in Schizophrenia and Mania by Strauss, Milton E., Prescott, Carol A., Gutterman, Diane F., Tune, Larry E.

“…Reduced perceptual span has been suggested to be a cognitive marker of vulnerability to schizophrenia. However, the specificity of this impairment in visual…”
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Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease by Schwartz, J M, Aylward, E, Barta, P E, Tune, L E, Pearlson, G D

“…Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality…”
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