Search Results - "TUNÇTAN, BAHAR"

Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery by Erden Ertürk,Sema, Urhan Küçük,Meral, Karaca,Kerem Mehmet, Şahan Fırat,Seyhan, Vezir,Özden, Canacankatan,Necmiye, Aytaçoğlu,Barlas Naim, Tunçtan,Bahar, Sucu,Nehir

“…Purpose: Ramipril is effective in treating inflammatory myocardial injury by reducing cytokines such as TNF-α, IL-6, and IL-8. In this study, we investigated…”
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NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IκB-α/NF-κB signaling pathway activity by Dilsah Ezgi Yilmaz, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Bahar Tunctan

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Pro-inflammatory GPR75 and anti-apoptotic phospholipase signaling pathways contribute to the ameliorating effect of soluble epoxide hydrolase inhibition on chronic experimental autoimmune encephalomyelitis in mice by Mehmet Furkan Horat, Sefika Pinar Senol, Omer Bahceli, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Serhan Sevim, Bahar Tunctan

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Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model by Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan-Firat, Seyhan, Tunctan, Bahar

“…A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous…”
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Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock by Tunctan, Bahar, Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sahan-Firat, Seyhan, Falck, John R., Malik, Kafait U.

“…•Shock is classified based on the: Hypovolemic, cardiogenic, obstructive, and vasodilatory.•Vasodilatory (vasoplegic, vasogenic, or distributive) shock may be…”
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mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats by Guden, Demet Sinem, Temiz-Resitoglu, Meryem, Senol, Sefika Pinar, Kibar, Deniz, Yilmaz, Sakir Necat, Tunctan, Bahar, Malik, Kafait U, Sahan-Firat, Seyhan

“…Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in…”
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Inhibition of mTOR protects against skeletal muscle and kidney injury following hindlimb ischemia-reperfusion in rats by regulating MEK1/ERK1/2 activity by Akıncı Uysal,Çağla, Temiz Reşitoğlu,Meryem, Güden,Demet Sinem, Şenol,Şefika Pınar, Vezir,Özden, Sucu,Nehir, Tunçtan,Bahar, Malik,Kafait U, Şahan Fırat,Seyhan

“…Purpose: We have previously demonstrated that activation of the mammalian target of rapamycin (mTOR)/inhibitory-κB-α/nuclear factor-κB p65 signaling pathway…”
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Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice by Ozgen, Beyza, Senol, Sefika Pinar, Yilmaz, Dilsah Ezgi, Temiz-Resitoglu, Meryem, Bahceli, Omer, Tunctan, Bahar

“…Objectives : This study aimed to investigate the effect of the gasdermin D (GSDMD) and mixed lineage kinase domain-like pseudokinase (MLKL) inhibitor,…”
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Koroner arter bypass cerrahisinde ramiprilin miyokardiyal hasar ve inflamatuvar yanıttaki etkisi üzerinde sitokin gen polimorfizmlerinin rolü by Küçük, Meral Urhan, Karaca, Kerem, Fırat, Seyhan Şahan, Vezir, Özden, Canacankatan, Necmiye, Aytaçoğlu, Barlas Naim, Erden, Sema, Tunçtan, Bahar, Sucu, Nehir

“…Amaç: Ramipril, inflamatuar miyokardial hasarın tedavisinde TNF-α, IL-6 ve IL-8 gibi sitokin seviyelerini azaltarak etkili olmaktadır. Çalışmamızda, ramipril…”
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Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats by Sari, A. Nihal, Kacan, Meltem, Unsal, Demet, Sahan Firat, Seyhan, Kemal Buharalioglu, C., Vezir, Ozden, Korkmaz, Belma, Cuez, Tuba, Canacankatan, Necmiye, Sucu, Nehir, Ayaz, Lokman, Tamer Gumus, Lulufer, Gorur, Aysegul, Tunctan, Bahar

“…The small G protein RhoA and its downstream effector Rho-kinase play an important role in various physiopathological processes including ischemia/reperfusion…”
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Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts by Urhan Küçük, Meral, Sucu, Nehir, Şahan Firat, Seyhan, Aytaçoğlu, Barlas Naim, Vezir, Özden, Bozali, Caner, Canacankatan, Necmiye, Kul, Seval, Tunçtan, Bahar

“…Background Angiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of…”
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CYP-derived eicosanoids in inflammatory diseases by Tunctan, Bahar

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Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production by Tunctan, Bahar, Yaghini, Fariborz A., Estes, Anne, Malik, Kafait U.

“…Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that…”
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Efficiency of l-arginine enriched cardioplegia and non-cardioplegic reperfusion in ischemic hearts by Kiziltepe, Ugursay, Tunçtan, Bahar, Eyileten, Zeynep Bastuzel, Sirlak, Mustafa, Arikbuku, Mehmet, Tasoz, Refik, Uysalel, Adnan, Ozyurda, Umit

“…Objective: Endothelial dysfunction with decreased nitric oxide (NO) levels has been implicated on reperfusion injury. Although l-arginine has been shown to…”
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Circadian variation of nitric oxide synthase activity in mouse tissue by Tunçtan, Bahar, Weigl, Yuval, Dotan, Aviva, Peleg, Leah, Zengil, Hakan, Ashkenazi, Israel, Abacioğlu, Nurettin

“…Endogenous nitric oxide (NO) is an important mediator in the processes that control biological clocks and circadian rhythms. The present study was designed to…”
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Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation by Sabrie, Zainab, Temiz-Resitoglu, Meryem, Kalkan, Taskin, Kilic, Banu, Tunctan, Bahar, Malik, Kafait U., Sahan-Firat, Seyhan

“…Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1)…”
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Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats by Temiz-Resitoglu, Meryem, Kucukkavruk, Sefika Pinar, Guden, Demet Sinem, Cecen, Pelin, Sari, Ayse Nihal, Tunctan, Bahar, Gorur, Aysegul, Tamer-Gumus, Lulufer, Buharalioglu, Cuneyt Kemal, Malik, Kafait U., Sahan-Firat, Seyhan

“…Mammalian target of rapamycin (mTOR), a serine/threonine kinase plays an important role in various pathophysiological processes including cancer, metabolic…”
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Determination of urinary levels of Bisphenol A in a Turkish population by Battal, Dilek, Cok, Ismet, Unlusayin, Irfan, Aktas, Ayca, Tunctan, Bahar

“…Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals that is widely used in common consumer products. The aim of this study was to…”
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Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms by Dolunay, Abdurrahman, Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan-Firat, Seyhan, Tunctan, Bahar

“…The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular signaling molecule that senses many environmental- and…”
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Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt–Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats by Temiz-Resitoglu, Meryem, Guden, Demet S., Senol, Sefika P., Vezir, Ozden, Sucu, Nehir, Kibar, Deniz, Yılmaz, Sakir N., Tunctan, Bahar, Malik, Kafait U., Sahan-Firat, Seyhan

“…The present study aimed to explore the contribution of mammalian target of rapamycin (mTOR) in deoxycorticosterone acetate (DOCA) salt-induced hypertension and…”
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